{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T16:54:03Z","timestamp":1769446443485,"version":"3.49.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T00:00:00Z","timestamp":1769212800000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>OBJECTIVES<\/jats:title>\n                    <jats:p>Despite the detrimental consequences associated with residual, progressive aortic regurgitation (AR) during LVAD support, correction of AR at LVAD implantation has rarely been shown to improve survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>A retrospective study was conducted using the Japanese registry database, which included 300 continuous-flow LVAD recipients with pre-existing AR (mild or greater). Patients were divided into two groups: those who underwent concomitant surgery for AR during LVAD implantation (n\u2009=\u200977) and those who did not (n\u2009=\u2009223). The groups were compared for significant AR development, all-cause mortality, and readmission for adverse events. A propensity score-matched cohort was also created to allow comparison of these outcomes to those of patients with similar baseline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>The cumulative incidence of significant AR was lower after corrected AR than after uncorrected AR in both the pre-matched and matched analyses (p\u2009&amp;lt;\u20090.05). While mortality and readmission rates were similar between groups in the pre-matched cohort, mortality after uncorrected AR was higher in the matched cohort (p\u2009=\u20090.052). When the pre-matched cohort was divided by age, a trend towards improved survival (p\u2009=\u20090.099) was observed with correction compared to no correction in older patients (\u226557 years), whereas the difference was negligible (p\u2009=\u20090.956) in younger patients (&amp;lt;57 years). These results were consistent in patients with mild AR at implantation, including the increased risk of significant AR for uncorrected AR (p\u2009=\u20090.058), as well as improved survival with AR correction in the older population (p\u2009=\u20090.054), but no survival difference in the younger population (p\u2009=\u20090.492).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>In older patients, correction of pre-existing AR, including mild AR, may improve long-term survival after LVAD implantation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ejcts\/ezag052","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T12:30:57Z","timestamp":1768912257000},"source":"Crossref","is-referenced-by-count":0,"title":["Improved survival with concomitant surgery for aortic regurgitation during continuous-flow left ventricular assist device implantation"],"prefix":"10.1093","author":[{"given":"Hiroki","family":"Kohno","sequence":"first","affiliation":[{"name":"Chiba University Graduate School of Medicine Department of Cardiovascular Surgery, , Chiba,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Goro","family":"Matsumiya","sequence":"additional","affiliation":[{"name":"Chiba University Graduate School of Medicine Department of Cardiovascular Surgery, , Chiba,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshikatsu","family":"Saiki","sequence":"additional","affiliation":[{"name":"Tohoku University Graduate School of Medicine Division of Cardiovascular Surgery, , Sendai,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasushi","family":"Sakata","sequence":"additional","affiliation":[{"name":"Osaka University Graduate School of Medicine Department of Cardiovascular Medicine, , Osaka,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minoru","family":"Ono","sequence":"additional","affiliation":[{"name":"The University of Tokyo Department of Cardiac Surgery, , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,1,24]]},"container-title":["European Journal of Cardio-Thoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ejcts\/advance-article-pdf\/doi\/10.1093\/ejcts\/ezag052\/66569742\/ezag052.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ejcts\/advance-article-pdf\/doi\/10.1093\/ejcts\/ezag052\/66569742\/ezag052.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T19:26:47Z","timestamp":1769369207000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejcts\/advance-article\/doi\/10.1093\/ejcts\/ezag052\/8440785"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,24]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1093\/ejcts\/ezag052","relation":{},"ISSN":["1873-734X"],"issn-type":[{"value":"1873-734X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,24]]},"article-number":"ezag052"}}