{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T23:21:18Z","timestamp":1787613678831,"version":"build-2736575974"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We evaluated the safety and efficacy of transcatheter aortic valve replacement (TAVR) up to 1-year follow-up for patients with severe pure aortic valve regurgitation (AR) or mixed severe aortic valve regurgitation and aortic valve stenosis (AR+AS) using a novel self-expandable bioprosthesis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>From 2021 to 2022, transapical TAVR using Ken-Valve (Jenscare Biotechnology Ltd, Ningbo, China) was performed in 142 symptomatic patients (mean age 70.3\u2009\u00b1\u20095.5 years) with pure AR (n\u2009=\u2009109) or AR+AS (n\u2009=\u200933) across 15 hospitals in China. All patients were considered high-risk or inoperable after heart team evaluation, with a mean Society of Thoracic Surgeons score of 5.9\u2009\u00b1\u20093.0%, and 99.3% in NYHA class III\/IV. Procedural characteristics, echocardiography data, and clinical outcomes up to 1-year were analysed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Technical success was achieved in 97.2% of cases. Two (1.4%) patients were converted to open surgery due to unsuitable anatomy or valve migration during the procedure. New permanent pacemakers were implanted in 20 (14.1%) patients. Three (2.1%) patients had stroke, and 3 (2.1%) patients had major bleeding. Thirty-day mortality was 2.1%, and all-cause mortality at 1-year was 5.6% (8\/142). Mean aortic valve gradient and effective orifice area (EOA) at 1-year postoperatively were 9.4\u2009\u00b1\u20095.4 mmHg and 1.9\u2009\u00b1\u20090.6 cm2, respectively. Significant improvement in clinical symptoms, positive left ventricular remodelling, and quality of life were observed up to 1-year. There was no significant difference in mortality, complications, and haemodynamic performance between patients with pure AR and AR+AS at 1-year.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>TAVR using the Ken-Valve was safe and effective in patients with pure AR or mixed AR+AS in mid-term.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical registration number<\/jats:title>\n                    <jats:p>NCT03788590.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ejcts\/ezag065","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T04:04:30Z","timestamp":1778040270000},"source":"Crossref","is-referenced-by-count":0,"title":["Transapical Transcatheter Valve Implantation for Aortic Regurgitation: A Multicentre, Prospective Trial"],"prefix":"10.1093","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0197-1242","authenticated-orcid":false,"given":"Bowen","family":"Xiao","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery, West China Hospital\/West China School of Medicine, Sichuan University , Chengdu, 610041,","place":["China"]},{"name":"Cardiovascular Research Laboratory, West China Hospital\/West China School of Medicine, Sichuan University , Chengdu, 610041,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, West China Hospital\/West China School of Medicine, Sichuan University , Chengdu, 610041,","place":["China"]},{"name":"Cardiovascular Research Laboratory, West China Hospital\/West China School of Medicine, Sichuan University , Chengdu, 610041,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lulu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, West China Hospital\/West China School of Medicine, Sichuan University , Chengdu, 610041,","place":["China"]},{"name":"Cardiovascular Research Laboratory, West China Hospital\/West China School of Medicine, Sichuan University , Chengdu, 610041,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, West China Hospital\/West China School of Medicine, Sichuan University , Chengdu, 610041,","place":["China"]},{"name":"Cardiovascular Research Laboratory, West China Hospital\/West China School of Medicine, Sichuan University , Chengdu, 610041,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Capital Medical University Department of Cardiovascular Surgery, Beijing Anzhen Hospital, , No. 2 Anzhen Road, Chaoyang District, Beijing 100029,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Meng","sequence":"additional","affiliation":[{"name":"Capital Medical University Department of Cardiovascular Surgery, Beijing Anzhen Hospital, , No. 2 Anzhen Road, Chaoyang District, Beijing 100029,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9359-4754","authenticated-orcid":false,"given":"Liangwan","family":"Chen","sequence":"additional","affiliation":[{"name":"Fujian Medical University Department of Cardiovascular Surgery, Fujian Union Hospital, , 29 Xinquan Road, Gulou District, Fuzhou, 350001, Fujian,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiquan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Qilu Hospital of Shandong University Department of Cardiovascular Surgery, , 107 Wenhuaxi Road, Jinan, 250012, Shandong,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Ma","sequence":"additional","affiliation":[{"name":"Zhejiang University School of Medicine Department of Cardiovascular Surgery, The First Affiliated Hospital, , 79 Qingchun Road, Shangcheng District, Hangzhou, 310003, Zhejiang,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5437-599X","authenticated-orcid":false,"given":"Nianguo","family":"Dong","sequence":"additional","affiliation":[{"name":"Huazhong University of Science and Technology Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, , 1277 Jiefang Avenue, Jianghan District, Wuhan, 430022, Hubei,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoke","family":"Shang","sequence":"additional","affiliation":[{"name":"Huazhong University of Science and Technology Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, , 1277 Jiefang Avenue, Jianghan District, Wuhan, 430022, Hubei,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2059-1912","authenticated-orcid":false,"given":"Jian","family":"Yang","sequence":"additional","affiliation":[{"name":"Air Force Medical University Department of Cardiovascular Surgery, Xijing Hospital, , 127 Changle West Road, Xincheng District, Xi\u2018an, 710032, Shaanxi,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[{"name":"Air Force Medical University Department of Cardiovascular Surgery, Xijing Hospital, , 127 Changle West Road, Xincheng District, Xi\u2018an, 710032, Shaanxi,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingfan","family":"Wang","sequence":"additional","affiliation":[{"name":"Henan Provincial Chest Hospital Department of Cardiovascular Surgery, , 1 Weiwu Road, Jinshui District, Zhengzhou, 450008, Henan,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingbin","family":"Xiao","sequence":"additional","affiliation":[{"name":"Xinqiao Hospital, Army Medical University Department of Cardiovascular Surgery, , 83 Xinqiao Street, Shapingba District, Chongqing, 400037,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangbin","family":"Pan","sequence":"additional","affiliation":[{"name":"Yunnan Fuwai Cardiovascular Hospital Department of Cardiovascular Surgery, , 528 Shahai Road, Wuhua District, Kunming, 650102, Yunnan,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian\u2019an","family":"Wang","sequence":"additional","affiliation":[{"name":"Zhejiang University School of Medicine Department of Cardiovascular Surgery, The Second Affiliated Hospital, , 88 Jiefang Road, Shangcheng District, Hangzhou, 310009, Zhejiang,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Shanghai Chest Hospital Department of Cardiovascular Surgery, , 241 Huaihai West Road, Xuhui District, Shanghai, 200030,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiming","family":"Guo","sequence":"additional","affiliation":[{"name":"Guangdong Provincial People\u2019s Hospital Department of Cardiovascular Surgery, , 106 Zhongshan Second Road, Yuexiu District, Guangzhou, 510080, Guangdong,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Liu","sequence":"additional","affiliation":[{"name":"Guangdong Provincial People\u2019s Hospital Department of Cardiovascular Surgery, , 106 Zhongshan Second Road, Yuexiu District, Guangzhou, 510080, Guangdong,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongjin","family":"Wang","sequence":"additional","affiliation":[{"name":"Nanjing Drum Tower Hospital Department of Cardiovascular Surgery, , The Affiliated Hospital of Nanjing University Medical School, 321 Zhongshan Road, Gulou District, Nanjing, 210008, Jiangsu,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4573-5441","authenticated-orcid":false,"given":"Zhiyun","family":"Xu","sequence":"additional","affiliation":[{"name":"Changhai Hospital, Naval Medical University Department of Cardiovascular Surgery, , 168 Changhai 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