{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T08:17:37Z","timestamp":1771489057875,"version":"3.50.1"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate how recurrence patterns in oesophageal squamous cell carcinoma (ESCC) are influenced by primary tumour location, treatment modality, and pathologic stage, and distinguish true recurrence from frequent secondary primary malignancies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 953 ESCC patients (mean age, 62.6\u2009\u00b1\u20097.7 years, 883 [92.7%] male) who underwent curative-intent oesophagectomy between 2010 and 2020 were retrospectively analysed. Patients were categorized by tumour location (upper\/mid vs lower), pathologic stage (0-I vs II-IV), and treatment modality (upfront surgery vs neoadjuvant chemoradiation). Recurrence patterns were classified as loco-regional, distant, or mixed. Secondary primary malignancies were also documented. Associations between recurrence patterns and post-recurrence survival (PRS) were assessed using multivariable Cox regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Recurrence occurred in 23.4% (223\/953) of patients, mostly within 2 years post-surgery (83.4%). Among early pathologic stage (0-I) patients treated with upfront surgery, upper\/mid oesophageal cancers had a higher rate of loco-regional recurrence compared with lower oesophageal cancers (16.3% vs 6.7%; P\u2009=\u2009.003), particularly in the mediastinal (10.9% vs 4.8%) and supraclavicular lymph nodes (6.3% vs 1.4%). No location-related differences were observed in advanced pathologic stage (II-IV) or neoadjuvant chemoradiation groups. Distant recurrence predominated in the neoadjuvant chemotherapy group (19.6% vs 9.7%). The lung was the most frequent site of distant metastasis (7.6%-8.6%), presenting as solitary nodules (24\/45). Secondary lung cancers occurred later than pulmonary recurrences (median 58.3 vs 6.9 months; P\u2009&amp;lt;\u2009.001). Mixed recurrence was associated with worse PRS (adjusted hazard ratio, 1.77; 95% confidence interval, 1.18-2.66; P\u2009=\u2009.006).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>ESCC recurrence patterns vary by tumour location, treatment modality, and pathologic stage. The lung is the most common site of distant recurrence and presents earlier than secondary lung cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ejcts\/ezag068","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T12:38:17Z","timestamp":1769171897000},"source":"Crossref","is-referenced-by-count":0,"title":["Recurrence Patterns of Oesophageal Squamous Cell Carcinoma Differ by Tumour Location and Pathologic Stage"],"prefix":"10.1093","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9188-1186","authenticated-orcid":false,"given":"Yura","family":"Ahn","sequence":"first","affiliation":[{"name":"Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center , Seoul 05505,","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7627-2000","authenticated-orcid":false,"given":"Sang Min","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center , Seoul 05505,","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung Im","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center , Seoul 05505,","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyung-Hyun","family":"Do","sequence":"additional","affiliation":[{"name":"Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center , Seoul 05505,","place":["Republic of Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joon Beom","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of 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