{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T10:01:34Z","timestamp":1777543294812,"version":"3.51.4"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100020453","name":"W. L. Gore & Associates","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the results of thoracic endovascular aortic repair (TEVAR) in large (diameter \u22657 cm) aneurysms of the descending thoracic aorta.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cohort has been extrapolated from the prospective, observational (on-label and off-label), worldwide multicentre Global Registry for Endovascular Aortic Treatment (GREAT) (NCT01658787). Patients were divided into 2 groups based on the baseline aortic diameter: standard aneurysms (&amp;lt;7 cm) and larger aneurysms (\u22657 cm). Primary outcomes were overall survival and freedom from TEVAR-related reintervention. Secondary outcomes were freedom from aortic-related mortality (ARM), as well as from type 1 endoleaks, and cumulative risk of TEVAR-related infection and\/or aorto-bronchial\/oesophageal fistulization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We analysed 613 (80.4%) patients with standard aneurysms and 149 (19.6%) with larger aneurysms. Demographic data and comorbidities were not different between the groups. At the 4- to 6-year window, 496 (65.1%) patients remained under follow-up (standard, n\u2009=\u2009409 [66.7%] vs large, n\u2009=\u200987 [58.4%]; odds ratio [OR]: 1.4, P\u2009=\u2009.056). Large aneurysm diameter was independently associated with higher hazards for all-cause mortality (hazard ratio [HR]: 1.6, 95% CI, 1.19-2.20; P\u2009&amp;lt;\u2009.001), TEVAR-related reintervention (HR: 2.4, 95% CI, 1.52-3.65; P\u2009&amp;lt;\u2009.001), risk of ARM (HR: 2.2, 95% CI, 1.03-4.75; P\u2009=\u2009.026), cumulative risk of TEVAR-related infection\/fistulization, and type 1 endoleaks (HR: 3.3, 95% CI, 1.89-5.65; P\u2009&amp;lt;\u2009.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Preoperative descending thoracic aortic diameter seems to be an important determinant of outcomes after TEVAR, where patients presenting with aortic diameter \u2264 7 cm showed more favourable long-term outcomes.<\/jats:p>\n                  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