{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T03:26:31Z","timestamp":1793849191182,"version":"4.6.1"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"11-12","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,11,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Superior survival outcomes have been reported for younger patients receiving durable left ventricular assist devices (LVADs) in Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS). We explored whether these findings extend to contemporary European practice leveraging on EUROMACS (European Registry for Patients with Mechanical Circulatory Support).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Adult patients undergoing implantation of current-generation magnetically levitated LVADs in EUROMACS were stratified according to age groups. The primary outcome was 5-year on-device survival, censored at heart transplantation (HT) or LVAD explantation. Secondary outcomes included LVAD explant for myocardial recovery and survival free from major adverse events (bleeding, stroke, device-related infection, or device malfunction). Death incidence accounting for HT and support cessation as competing risks was also calculated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 2850 patients undergoing HeartMate 3 implantation were included (&amp;lt;50 years: 23.5%; 50-59 years: 29.7%; 60-69 years: 38.0%; \u226570 years: 8.8%). Younger patients had fewer comorbidities, a higher prevalence of non-ischaemic cardiomyopathy, and INTERMACS profile \u22643. Younger patients had superior on-device 5-year survival (&amp;lt;50 years: 74.7%; 50-59 years: 65.5%; 60-69 years: 53.9%; \u226570 years: 48.8%; P\u2009&amp;lt;\u2009.001) and LVAD explantation for myocardial recovery (&amp;lt;50 years: 4.3%; 50-59 years: 1.8%; 60-69 years: 2.3%; \u226570 years: 0.4%; P\u2009=\u2009.031). Accounting for competing outcomes, the 5-year cumulative incidence of death was lowest among younger patients (&amp;lt;50 years: 20.8%; 50-59 years: 29.1%; 60-69 years: 40.8%; \u226570 years: 49.5%; P\u2009&amp;lt;\u2009.001), driven by higher HT rates. Survival free from bleeding was significantly higher in younger patients (P\u2009&amp;lt;\u2009.001). In contrast, 5-year freedom from stroke, device-related infection, and device malfunction was similar across age groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In contemporary European practice, patients &amp;lt;50 years undergoing LVAD implant had high 5-year survival approaching that reported in cohorts of patients listed for HT. These findings support further investigation of prolonged LVAD support before HT as a potential strategy to maximize lifetime benefit in selected motivated younger candidates.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ejcts\/ezag234","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:39:25Z","timestamp":1790681965000},"source":"Crossref","is-referenced-by-count":0,"title":["Long-Term Outcomes of Contemporary Durable Left Ventricular Assist Device Support in Younger Patients: A EUROMACS Analysis"],"prefix":"10.1093","volume":"68","author":[{"given":"Guglielmo","family":"Gallone","sequence":"first","affiliation":[{"name":"Cardiovascular and Thoracic Department, \u201cCitt\u00e0 della Salute e della Scienza\u201d Hospital , 10126 Turin,","place":["Italy"]},{"name":"Department of Medical Sciences, University of Turin , 10126 Turin,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin M","family":"Veen","sequence":"additional","affiliation":[{"name":"Department of Surgery, Thorax Center, Erasmus Medical Center , 3015 GD Rotterdam,","place":["Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9974-8091","authenticated-orcid":false,"given":"Alexander M","family":"Bernhardt","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, University Heart and Vascular Center Hamburg , 20246 Hamburg,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kadir","family":"Caliskan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Thorax Center, Cardiovascular Institute, Erasmus MC University Medical Center , 3015 GD Rotterdam,","place":["Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emil","family":"Najjar","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Karolinska University Hospital, 171 76 Stockholm, Sweden; Department of Medicine, Karolinska Institutet, 171 77 Stockholm,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Netuka","sequence":"additional","affiliation":[{"name":"Institute for Clinical and Experimental Medicine (IKEM) , 140 21 Prague,","place":["Czech Republic"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Mara","family":"Scandroglio","sequence":"additional","affiliation":[{"name":"Cardiac Intensive Care Unit, IRCCS San Raffaele Scientific Institute , 20132 Milan,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Spitaleri","sequence":"additional","affiliation":[{"name":"Cardiovascular and Thoracic Department, \u201cCitt\u00e0 della Salute e della Scienza\u201d Hospital , 10126 Turin,","place":["Italy"]},{"name":"Department of Surgical Sciences, University of Turin , 10126 Turin,","place":["Italy"]},{"name":"PhD programme in Bioengineering and Medical-Surgical Sciences, University of Turin , Politecnico di Torino, 10126 Turin,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Sangiorgi","sequence":"additional","affiliation":[{"name":"Cardiovascular Department, Maria Cecilia Hospital, GVM Care & Research , Cotignola, Ravenna 48033,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1803-604X","authenticated-orcid":false,"given":"Peter","family":"Ivak","sequence":"additional","affiliation":[{"name":"Institute for Clinical and Experimental Medicine (IKEM) , 140 21 Prague,","place":["Czech Republic"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnt","family":"Fiane","sequence":"additional","affiliation":[{"name":"Department of cardiothoracic surgery, Oslo University Hospital and Faculty of Medicine , 0372 Oslo,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feras","family":"Khaliel","sequence":"additional","affiliation":[{"name":"Adult Cardiac Surgery Section, Department of Surgery, Heart Center, King Faisal Specialist Hospital & Research Center, 11211 Riyadh, Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0259-0799","authenticated-orcid":false,"given":"Mustafa","family":"\u00d6zbaran","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Ege University Hospital , 35100 Izmir,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7249-0510","authenticated-orcid":false,"given":"Yuri","family":"Pya","sequence":"additional","affiliation":[{"name":"National Research Cardiac Surgery Center , 010000 Astana,","place":["Kazakhstan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2185-4895","authenticated-orcid":false,"given":"Daniel","family":"Zimpfer","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Medical University of Vienna, 1090 Vienna,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria","family":"F\u00e4rber","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, University Hospital W\u00fcrzburg , 97080 W\u00fcrzburg,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Gummert","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Herz- und Diabeteszentrum NRW , 32545 Bad Oeynhausen,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8110-4009","authenticated-orcid":false,"given":"Bart","family":"Meyns","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences, Katholieke Universiteit Leuven , 3000 Leuven,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7620-8981","authenticated-orcid":false,"given":"Paola","family":"Quattroni","sequence":"additional","affiliation":[{"name":"EUROMACS, EACTS House , Windsor SL4 1EU,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8221-1295","authenticated-orcid":false,"given":"Felix","family":"Schoenrath","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum der Charit\u00e9 (DHZC), DZHK (German Centre for Cardiovascular 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