{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T20:33:48Z","timestamp":1793651628565,"version":"4.5.1"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"11-12","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,11,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Postoperative air leakage following lung surgery prolongs chest drainage duration and length of hospitalization and the evidence regarding treatment with autologous blood pleurodesis (ABP) is scarce. We decided to investigate if ABP would influence postoperative air leakage when used on the first postoperative day following elective video-assisted thoracoscopic surgery (VATS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this multicentre randomized controlled trial, patients with an air leakage greater than 40 mL\/min during cough and mobilization on their first postoperative day following elective VATS were randomized 1:1 to standard chest drain management with or without ABP (stratified by lobectomy or wedge resection). The chest drain was removed after standardized digital drainage criteria, and the primary endpoint was time to chest drain removal. Patients with persistent air leakage beyond postoperative day 7 were censored to allow for individualized management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 268 patients were randomized (134 in each group), after lobectomy (n\u2009=\u2009238) or wedge (n\u2009=\u200930). Median chest drain duration was 3.4 days (95% CI, 3.0\u20134.9) in the ABP group vs 5.0 days (95% CI, 4.0\u20136.8) in the control group (P\u2009=\u2009.007). By postoperative day 7, chest drains had been removed in 74% vs 62% of patients, respectively. ABP significantly increased the rate of chest drain removal (HR 1.49; 95% CI, 1.11\u20132.01; P\u2009=\u2009.007). The treatment effect was consistent across both participating centres.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Early autologous blood pleurodesis significantly shortens chest drain duration in patients with postoperative air leakage following VATS. This simple and low-cost intervention should be considered in Enhanced Recovery After Surgery protocols after thoracic surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ejcts\/ezag235","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:39:20Z","timestamp":1790681960000},"source":"Crossref","is-referenced-by-count":0,"title":["Autologous Blood Pleurodesis for Postoperative Air Leakage Following Video-Assisted Thoracoscopic Surgery\u2013A Randomized Controlled Trial"],"prefix":"10.1093","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2929-3073","authenticated-orcid":false,"given":"Finn Amundsen","family":"Dittberner","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic Surgery, Odense University Hospital , DK-5000 Odense,","place":["Denmark"]},{"name":"Department of Clinical Research, University of Southern Denmark , DK-5230 Odense,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6509-8510","authenticated-orcid":false,"given":"Thomas Decker","family":"Christensen","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic and Vascular Surgery, Aarhus University Hospital , DK-8200 Aarhus,","place":["Denmark"]},{"name":"Department of Clinical Medicine, Aarhus University , DK-8200 Aarhus,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1270-8068","authenticated-orcid":false,"given":"Peter Bj\u00f8rn","family":"Licht","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Odense University Hospital , DK-5000 Odense,","place":["Denmark"]},{"name":"Department of Clinical Research, University of Southern Denmark , DK-5230 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