{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T16:01:20Z","timestamp":1790438480343,"version":"4.1.0"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2018,2,13]],"date-time":"2018-02-13T00:00:00Z","timestamp":1518480000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/about_us\/legal\/notices"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,7,1]]},"DOI":"10.1093\/ejcts\/ezy018","type":"journal-article","created":{"date-parts":[[2018,1,9]],"date-time":"2018-01-09T07:14:55Z","timestamp":1515482095000},"page":"134-140","source":"Crossref","is-referenced-by-count":31,"title":["Is central lung tumour location really predictive for occult mediastinal nodal disease in (suspected) non-small-cell lung cancer staged cN0 on 18F-fluorodeoxyglucose positron emission tomography\u2013computed tomography?"],"prefix":"10.1093","volume":"54","author":[{"given":"Herbert","family":"Decaluw\u00e9","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery, University Hospitals Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johnny","family":"Moons","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, University Hospitals Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen","family":"Fieuws","sequence":"additional","affiliation":[{"name":"Leuven Biostatistics and Statistical Bioinformatics Centre (L-BioStat), Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"De Wever","sequence":"additional","affiliation":[{"name":"Department of Radiology, University Hospitals Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Deroose","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University Hospitals Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Stanzi","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, University Hospitals Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lieven","family":"Depypere","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, University Hospitals Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristiaan","family":"Nackaerts","sequence":"additional","affiliation":[{"name":"Department of Respiratory Oncology & Pulmonology, University Hospitals Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Coolen","sequence":"additional","affiliation":[{"name":"Department of Radiology, University Hospitals Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten","family":"Lambrecht","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy, University Hospitals Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Verbeken","sequence":"additional","affiliation":[{"name":"Department of Pathology, University Hospitals Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"De Ruysscher","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy, University Hospitals Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Vansteenkiste","sequence":"additional","affiliation":[{"name":"Leuven Biostatistics and Statistical Bioinformatics Centre (L-BioStat), Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Van Raemdonck","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, University Hospitals Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"De Leyn","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, University Hospitals Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Dooms","sequence":"additional","affiliation":[{"name":"Department of Respiratory Oncology & Pulmonology, University Hospitals Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Leuven Lung Cancer Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,2,13]]},"reference":[{"key":"key\n\t\t\t\t20180618200031_ezy018-B1","doi-asserted-by":"crossref","first-page":"iv1","DOI":"10.1093\/annonc\/mdx222","article-title":"Early and locally advanced non-small-cell lung cancer (NSCLC): ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up","volume":"28","author":"Postmus","year":"2017","journal-title":"Ann Oncol"},{"key":"key\n\t\t\t\t20180618200031_ezy018-B2","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.athoracsur.2007.03.081","article-title":"Risk factors for occult mediastinal metastases in clinical stage I non-small cell lung cancer","volume":"84","author":"Lee","year":"2007","journal-title":"Ann Thorac Surg"},{"key":"key\n\t\t\t\t20180618200031_ezy018-B3","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.ejcts.2007.09.026","article-title":"Pattern and predictors of occult mediastinal lymph node involvement in non-small cell lung cancer patients with negative mediastinal uptake on positron emission tomography","volume":"33","author":"Al-Sarraf","year":"2008","journal-title":"Eur J Cardiothorac Surg"},{"key":"key\n\t\t\t\t20180618200031_ezy018-B4","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1016\/j.jtcvs.2012.06.050","article-title":"A prediction model for N2 disease in T1 non-small cell lung cancer","volume":"144","author":"Zhang","year":"2012","journal-title":"J Thorac Cardiovasc Surg"},{"key":"key\n\t\t\t\t20180618200031_ezy018-B5","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1016\/j.athoracsur.2013.06.038","article-title":"Development and validation of a clinical prediction model for N2 lymph node metastasis in non-small cell lung cancer","volume":"96","author":"Chen","year":"2013","journal-title":"Ann Thorac Surg"},{"key":"key\n\t\t\t\t20180618200031_ezy018-B6","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.lungcan.2017.04.018","article-title":"Indications for invasive mediastinal staging in patients with early non-small cell lung cancer staged with PET-CT","volume":"109","author":"Gao","year":"2017","journal-title":"Lung Cancer"},{"key":"key\n\t\t\t\t20180618200031_ezy018-B7","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1093\/ejcts\/ezu028","article-title":"Revised ESTS guidelines for preoperative mediastinal lymph node staging for non-small-cell lung cancer","volume":"45","author":"De Leyn","year":"2014","journal-title":"Eur J Cardiothorac Surg"},{"key":"key\n\t\t\t\t20180618200031_ezy018-B8","year":"2017"},{"key":"key\n\t\t\t\t20180618200031_ezy018-B9","doi-asserted-by":"crossref","first-page":"e211S","DOI":"10.1378\/chest.12-2355","article-title":"Methods for staging non-small cell lung cancer","volume":"143","author":"Silvestri","year":"2013","journal-title":"Chest"},{"key":"key\n\t\t\t\t20180618200031_ezy018-B10","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.jtcvs.2006.05.023","article-title":"Location as an important predictor of lymph node involvement for pulmonary adenocarcinoma","volume":"132","author":"Ketchedjian","year":"2006","journal-title":"J Thorac Cardiovasc Surg"},{"key":"key\n\t\t\t\t20180618200031_ezy018-B11","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1093\/ejcts\/ezv489","article-title":"Central tumour location should be considered when comparing N1 upstaging between thoracoscopic and open surgery for clinical stage I non-small-cell lung cancer","volume":"50","author":"Decaluwe","year":"2016","journal-title":"Eur J Cardiothorac Surg"},{"key":"key\n\t\t\t\t20180618200031_ezy018-B12","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1093\/ejcts\/ezr272","article-title":"False-negative rate after positron emission tomography\/computer tomography scan for mediastinal staging in cI stage non-small-cell lung cancer","volume":"42","author":"Gomez-Caro","year":"2012","journal-title":"Eur J Cardiothorac Surg"},{"key":"key\n\t\t\t\t20180618200031_ezy018-B13","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1001\/jama.2010.261","article-title":"Stereotactic body radiation therapy for inoperable early stage lung cancer","volume":"303","author":"Timmerman","year":"2010","journal-title":"JAMA"},{"key":"key\n\t\t\t\t20180618200031_ezy018-B14","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1513\/AnnalsATS.201607-568BC","article-title":"What exactly is a centrally located lung tumor? Results of an online survey","volume":"14","author":"Casal","year":"2017","journal-title":"Ann Am Thorac Soc"},{"key":"key\n\t\t\t\t20180618200031_ezy018-B15","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1097\/JTO.0b013e3181a0d82e","article-title":"The IASLC lung cancer staging project: a proposal for a new international lymph node map in the forthcoming seventh edition of the TNM classification for lung cancer","volume":"4","author":"Rusch","year":"2009","journal-title":"J Thorac Oncol"},{"key":"key\n\t\t\t\t20180618200031_ezy018-B16","volume-title":"UICC TNM Classification of Malignant Tumours","author":"Brierly","year":"2016","edition":"8th edn."},{"key":"key\n\t\t\t\t20180618200031_ezy018-B17","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.ejcts.2006.08.008","article-title":"ESTS guidelines for intraoperative lymph node staging in non-small cell lung cancer","volume":"30","author":"Lardinois","year":"2006","journal-title":"Eur J Cardiothorac Surg"},{"key":"key\n\t\t\t\t20180618200031_ezy018-B18","doi-asserted-by":"crossref","first-page":"837","DOI":"10.2307\/2531595","article-title":"Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach","volume":"44","author":"DeLong","year":"1988","journal-title":"Biometrics"},{"key":"key\n\t\t\t\t20180618200031_ezy018-B19","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1016\/j.ejcts.2009.12.013","article-title":"Incidence of occult mediastinal node involvement in cN0 non-small-cell lung cancer patients after negative uptake of positron emission tomography\/computer tomography scan","volume":"37","author":"Gomez-Caro","year":"2010","journal-title":"Eur J Cardiothorac Surg"},{"key":"key\n\t\t\t\t20180618200031_ezy018-B20","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.lungcan.2010.06.008","article-title":"Occult mediastinal lymph node metastasis in NSCLC patients diagnosed as clinical N0-1 by preoperative integrated FDG-PET\/CT and CT: risk factors, pattern, and histopathological study","volume":"71","author":"Kanzaki","year":"2011","journal-title":"Lung Cancer"},{"key":"key\n\t\t\t\t20180618200031_ezy018-B21","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.athoracsur.2013.03.050","article-title":"Predictive factors for node metastasis in patients with clinical stage I non-small cell lung cancer","volume":"96","author":"Cho","year":"2013","journal-title":"Ann Thorac Surg"},{"key":"key\n\t\t\t\t20180618200031_ezy018-B22","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1378\/chest.14-0534","article-title":"Endosonography for mediastinal nodal staging of clinical N1 non-small cell lung cancer: a prospective multicenter study","volume":"147","author":"Dooms","year":"2015","journal-title":"Chest"},{"key":"key\n\t\t\t\t20180618200031_ezy018-B23","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1097\/JTO.0b013e3182992421","article-title":"A prediction model for pathologic N2 disease in lung cancer patients with a negative mediastinum by positron emission tomography","volume":"8","author":"Farjah","year":"2013","journal-title":"J Thorac Oncol"},{"key":"key\n\t\t\t\t20180618200031_ezy018-B24","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1093\/ejcts\/ezx338","article-title":"Multicentric evaluation of the impact of central tumour location when comparing rates of N1 upstaging in patients undergoing video-assisted and open surgery for clinical Stage I non-small-cell lung cancer","volume":"53","author":"Decaluw\u00e9","year":"2018","journal-title":"Eur J Cardiothorac Surg"},{"key":"key\n\t\t\t\t20180618200031_ezy018-B25","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.cllc.2011.08.002","article-title":"Negative predictive value of positron emission tomography and computed tomography for Stage T1-2N0 non\u2013small-cell lung cancer: a meta-analysis","volume":"13","author":"Wang","year":"2012","journal-title":"Clin Lung Cancer"},{"key":"key\n\t\t\t\t20180618200031_ezy018-B26","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1097\/JTO.0b013e3181d95cc8","article-title":"Prognostic value of fluorodeoxyglucose uptake in non-small cell lung cancer: time for standardization and validation","volume":"5","author":"Dooms","year":"2010","journal-title":"J Thorac Oncol"},{"key":"key\n\t\t\t\t20180618200031_ezy018-B27","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1200\/JCO.1998.16.6.2142","article-title":"Lymph node staging in non-small-cell lung cancer with FDG-PET scan: a prospective study on 690 lymph node stations from 68 patients","volume":"16","author":"Vansteenkiste","year":"1998","journal-title":"J Clin Oncol"},{"key":"key\n\t\t\t\t20180618200031_ezy018-B28","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.jtcvs.2014.08.075","article-title":"Utility of mediastinoscopy in clinical stage I lung cancers at risk for occult mediastinal nodal metastases","volume":"149","author":"Fernandez","year":"2015","journal-title":"J Thorac Cardiovasc Surg"}],"container-title":["European Journal of Cardio-Thoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ejcts\/article-pdf\/54\/1\/134\/25052622\/ezy018.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,9]],"date-time":"2019-10-09T00:40:56Z","timestamp":1570581656000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejcts\/article\/54\/1\/134\/4855994"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,13]]},"references-count":28,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,2,13]]},"published-print":{"date-parts":[[2018,7,1]]}},"URL":"https:\/\/doi.org\/10.1093\/ejcts\/ezy018","relation":{},"ISSN":["1010-7940","1873-734X"],"issn-type":[{"value":"1010-7940","type":"print"},{"value":"1873-734X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,7]]},"published":{"date-parts":[[2018,2,13]]}}}