{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T04:26:34Z","timestamp":1740111994766,"version":"3.37.3"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2019,2,27]],"date-time":"2019-02-27T00:00:00Z","timestamp":1551225600000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100005633","name":"Finnish Foundation for Cardiovascular research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005633","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Oulu University Hospital"},{"DOI":"10.13039\/501100006306","name":"Sigrid Jus\u00e9lius Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006306","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p\/><jats:sec><jats:title>OBJECTIVES<\/jats:title><jats:p>Type A aortic dissection requires immediate surgery. Traditional cannulation methods such as the central aortic cannulation with the Seldinger technique and axillary cannulation are primary choices. Yet in the presence of tamponade or severe cardiogenic shock, these can be too time-consuming to complete. Direct true lumen cannulation after venous exsanguination not only avoids this issue but also leads to transient global ischaemia. We studied the safety of direct true lumen cannulation from the aspect of global ischaemia in a surviving porcine model.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Twelve pigs were randomized to either control or intervention groups (6\u2009+\u20096). The intervention group underwent simulated direct true lumen cannulation by exsanguination and circulatory arrest for 5\u2009min at 35\u00b0C before cardiopulmonary bypass (CPB). Both groups underwent CPB cooling to 25\u00b0C followed by a 25-min arrest period and subsequent warming to 36\u00b0C. Neuron-specific enolase levels were measured at 6 time-points from blood samples. Near-infrared spectroscopy was used to determine brain oxygenation. The neurological recovery was evaluated daily during a 7-day follow-up, and the brain was harvested for a histopathological analysis after euthanization.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>All pigs recovered their normal neurological behaviour. The neurobehavioural total score on postoperative day 2 reached borderline statistical significance, thus favouring the intervention group [(9 (8.75\u20139) vs 6.5 (5.5\u20139), P\u2009=\u20090.06]. Near-infrared spectroscopy values and neuron-specific enolase levels slightly favoured the control group during the cooling period, but the difference was not clinically significant. The histopathological analysis showed no difference between the groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>A 5-min period of normothermic global ischaemia before CPB does not impair the neurological outcome following hypothermic circulatory arrest in a surviving porcine model.<\/jats:p><\/jats:sec>","DOI":"10.1093\/ejcts\/ezz047","type":"journal-article","created":{"date-parts":[[2019,2,5]],"date-time":"2019-02-05T04:15:17Z","timestamp":1549340117000},"page":"451-457","source":"Crossref","is-referenced-by-count":1,"title":["Safety of direct true lumen cannulation after venous exsanguination: a study in a surviving porcine model\u2020"],"prefix":"10.1093","volume":"56","author":[{"given":"Caius","family":"Mustonen","sequence":"first","affiliation":[{"name":"Research Unit of Surgery, Anesthesia and Intensive Care, University of Oulu and Medical Research Center, Oulu, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannu-Pekka","family":"Honkanen","sequence":"additional","affiliation":[{"name":"Research Unit of Surgery, Anesthesia and Intensive Care, University of Oulu and Medical Research Center, Oulu, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siri","family":"Lehtonen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Oulu University Hospital, Oulu, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannu","family":"Tuominen","sequence":"additional","affiliation":[{"name":"Department of Pathology, Oulu University Hospital, Oulu, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tuomas","family":"M\u00e4kel\u00e4","sequence":"additional","affiliation":[{"name":"Research Unit of Surgery, Anesthesia and Intensive Care, University of Oulu and Medical Research Center, Oulu, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timo","family":"Kaakinen","sequence":"additional","affiliation":[{"name":"Research Unit of Surgery, Anesthesia and Intensive Care, University of Oulu and Medical Research Center, Oulu, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fredrik","family":"Yannopoulos","sequence":"additional","affiliation":[{"name":"Research Unit of Surgery, Anesthesia and Intensive Care, University of Oulu and Medical Research Center, Oulu, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vesa","family":"Anttila","sequence":"additional","affiliation":[{"name":"Research Unit of Surgery, Anesthesia and Intensive Care, University of Oulu and Medical Research Center, Oulu, Finland"},{"name":"Heart Center, University of Turku, Turku University Hospital, Turku, 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