{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T12:17:18Z","timestamp":1754396238684,"version":"3.37.3"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2019,5,12]],"date-time":"2019-05-12T00:00:00Z","timestamp":1557619200000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p\/>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>The intermediate-term all-cause mortality rate of real-world patients with multivessel disease (MVD) treated with percutaneous coronary intervention (PCI) with new-generation drug-eluting stents or coronary artery bypass grafting (CABG) remains unknown. We sought to compare the intermediate-term all-cause mortality rates of real-world patients with MVD including left main stem disease, treated with CABG or PCI.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>All consecutive all-comer patients with MVD undergoing CABG or PCI with second\/third generation drug-eluting stents from 2007 to 2015 in Harefield Hospital, UK were included in this study. The revascularization modality was based on heart team discussions. Primary outcome was all-cause mortality. Mean follow-up of the study was 3.3\u2009years. Cox regression analysis and propensity matching were used.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Of 6383 patients with MVD, 4230 underwent CABG, whereas 2153 had PCI with new-generation stents. In the CABG group, the mean age was 66.4\u2009\u00b1\u200910\u2009years, whereas in the PCI group it was 65.3\u2009\u00b1\u200912.1\u2009years (P\u2009&lt;\u20090.001). Fewer female patients with MVD were treated with CABG than were treated with PCI (18.5% vs 20.5%; P\u2009=\u20090.026). There was a higher 5-year estimated survival rate among patients having CABG (88% vs 78.3%; Plog-rank\u2009&lt;\u20090.001). The adjusted hazard ratio (HR) for PCI over CABG was 1.74 [95% confidence interval (CI) 1.41\u20132.16; P\u2009&lt;\u20090.001]. A total of 653 patients having CABG and 653 having PCI were included in the propensity-matched groups. At mean follow-up, PCI was associated with a higher adjusted HR for all-cause mortality (2.18, 95% CI 1.54\u20133.1; P\u2009&lt;\u20090.001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>In this contemporary cohort of real-world patients with MVD, CABG was associated with increased intermediate-term survival compared to PCI with new-generation drug-eluting stents.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejcts\/ezz142","type":"journal-article","created":{"date-parts":[[2019,4,26]],"date-time":"2019-04-26T07:14:34Z","timestamp":1556262874000},"page":"911-918","source":"Crossref","is-referenced-by-count":10,"title":["Coronary artery bypass confers intermediate-term survival benefit over percutaneous coronary intervention with new-generation stents in real-world patients with multivessel coronary artery disease, including left main disease: a retrospective analysis of 6383 patients"],"prefix":"10.1093","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9894-9200","authenticated-orcid":false,"given":"Vasileios F","family":"Panoulas","sequence":"first","affiliation":[{"name":"Department of Interventional Cardiology, Harefield Hospital, Royal Brompton and Harefield NHS Foundation Trust, Greater London, UK"},{"name":"Cardiovascular Sciences, National Heart and Lung Institute, Imperial College London, South Kensington, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles J","family":"Ilsley","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology, Harefield Hospital, Royal Brompton and Harefield NHS Foundation Trust, Greater London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantinos","family":"Kalogeras","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology, Harefield Hospital, Royal Brompton and Harefield NHS Foundation Trust, Greater London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Habib","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Harefield Hospital, Royal Brompton and Harefield NHS Foundation Trust, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Monteagudo Vela","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Harefield Hospital, Royal Brompton and Harefield NHS Foundation Trust, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0823-5093","authenticated-orcid":false,"given":"Miles","family":"Dalby","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology, Harefield Hospital, Royal Brompton and Harefield NHS Foundation Trust, Greater London, UK"},{"name":"Cardiovascular Sciences, National Heart and Lung Institute, Imperial College London, South Kensington, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tito","family":"Kabir","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology, Harefield Hospital, Royal Brompton and Harefield NHS Foundation Trust, Greater London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert D","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology, Harefield Hospital, Royal Brompton and Harefield NHS Foundation Trust, Greater London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Mason","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology, Harefield Hospital, Royal Brompton and Harefield NHS Foundation Trust, Greater London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8469-2726","authenticated-orcid":false,"given":"Richard","family":"Grocott-Mason","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology, Harefield Hospital, Royal Brompton and Harefield NHS Foundation Trust, Greater London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian","family":"Cummings","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Harefield Hospital, Royal Brompton and Harefield NHS Foundation Trust, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas F","family":"L\u00fcscher","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology, Harefield Hospital, Royal Brompton and Harefield NHS Foundation Trust, Greater London, UK"},{"name":"Zurich Heart House, Center for Molecular Cardiology, University of Zurich, Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahzad G","family":"Raja","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Harefield Hospital, Royal Brompton and Harefield NHS Foundation Trust, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,5,11]]},"reference":[{"key":"2019101705192120100_ezz142-B1","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1001\/jamainternmed.2013.12844","article-title":"Coronary artery bypass grafting vs percutaneous coronary intervention and long-term mortality and morbidity in multivessel disease: meta-analysis of randomized clinical trials of the arterial grafting and stenting era","volume":"174","author":"Sipahi","year":"2014","journal-title":"JAMA Intern Med"},{"key":"2019101705192120100_ezz142-B2","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1016\/S0140-6736(09)60552-3","article-title":"Coronary 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