{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T09:13:30Z","timestamp":1775985210697,"version":"3.50.1"},"reference-count":25,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2019,7,11]],"date-time":"2019-07-11T00:00:00Z","timestamp":1562803200000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Adetec association and Edwards life sciences educational grant"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p\/>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>Aortic valve (AV) insufficiency with normal root and ascending aorta is most frequently treated by valve replacement with significant prosthetic-related complications and reduced life expectancy. We compared the outcomes of a new standardized isolated AV repair approach using an external aortic annuloplasty ring at the subvalvular level (single ring annuloplasty) and the role of an additional supravalvular ring at the sinotubular junction (double ring annuloplasty).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Single centre data were collected from the Aortic Valve Insufficiency and ascending aorta Aneurysm InternATiOnal Registry (AVIATOR) between 2003 and 2017. A total of 93 patients (56 single ring and 37 double ring) underwent isolated AV repair.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>The overall 30-day mortality rate and the need for a permanent pacemaker were 1% and 2%, respectively. The overall survival rate at 6\u2009years was similar for sex- and age-matched members of the general population (89% vs 95%; P\u2009=\u20090.1) and did not differ between the double and single ring groups (82% vs 93%; P\u2009=\u20090.4) at 6\u2009years. There were no thromboembolic or bleeding events in the entire cohort. However, at 6\u2009years, the cumulative incidence of valve-related reintervention was 26% in the single ring annuloplasty group compared to 3% in the double ring annuloplasty (P\u2009=\u20090.02) group. Similarly, at 6\u2009years, the cumulative incidence of moderate-to-severe (&gt;2) aortic insufficiency was 30% in the single ring annuloplasty group compared to 0% in the double ring annuloplasty group (P\u2009=\u20090.007).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Standardized AV repair with external ring annuloplasty has a survival rate similar to that of the general population. The additional stabilization of the sinotubular junction with a second supravalvular ring (double ring annuloplasty) is associated with better outcomes compared to single subvalvular annuloplasty. It can be considered as a first line intervention for patients with isolated aortic insufficiency and pliable leaflets.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejcts\/ezz193","type":"journal-article","created":{"date-parts":[[2019,7,3]],"date-time":"2019-07-03T11:08:29Z","timestamp":1562152109000},"source":"Crossref","is-referenced-by-count":7,"title":["Isolated aortic insufficiency valve repair with external ring annuloplasty: a standardized approach"],"prefix":"10.1093","author":[{"given":"Mustafa","family":"Zakkar","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery, L'Institut Mutualiste Montsouris, Paris, France"},{"name":"Department of Cardiovascular Sciences, University of Leicester, Clinical Sciences Wing, Glenfield Hospital, Leicester, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vito D","family":"Bruno","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Bristol Heart Institute, Bristol, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavel","family":"Zacek","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Charles University Hospital in Prague, Faculty of Medicine, Hradec Kralove, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle","family":"Di Centa","sequence":"additional","affiliation":[{"name":"Vascular Surgery Unit, Hospital Foch, Suresnes, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christophe","family":"Acar","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, L'Institut Mutualiste Montsouris, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nizar","family":"Khelil","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, L'Institut Mutualiste Montsouris, Paris, 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