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Thus, we systematically assessed the feasibility and safety of non-intubated VATS compared with intubated VATS perioperatively for the treatment of different thoracic diseases. An extensive search of literature databases was conducted. Perioperative outcomes were compared between 2 types of operations. The time trend of the overall results was evaluated through a cumulative meta-analysis. Subgroup analyses of different thoracic diseases and study types were examined. Twenty-seven studies including 2537 patients were included in the analysis. A total of 1283 patients underwent non-intubated VATS; intubated VATS was performed on the other 1254 patients. Overall, the non-intubated VATS group had fewer postoperative overall complications [odds ratios (OR) 0.505; P\u2009&lt;\u20090.001]; shorter postoperative fasting times [standardized mean difference (SMD) \u22122.653; P\u2009&lt;\u20090.001]; shorter hospital stays (SMD \u22120.581; P\u2009&lt;\u20090.001); shorter operative times (SMD \u22120.174; P\u2009=\u20090.041); shorter anaesthesia times (SMD \u22120.710; P\u2009&lt;\u20090.001) and a lower mortality rate (OR 0.123; P\u2009=\u20090.020). Non-intubated VATS may be a safe and feasible alternative to intubated VATS and provide a more rapid postoperative rehabilitation time than conventional intubated VATS.<\/jats:p>","DOI":"10.1093\/ejcts\/ezz279","type":"journal-article","created":{"date-parts":[[2019,10,17]],"date-time":"2019-10-17T19:37:26Z","timestamp":1571341046000},"source":"Crossref","is-referenced-by-count":14,"title":["Non-intubated spontaneous ventilation in video-assisted thoracoscopic surgery: a meta-analysis"],"prefix":"10.1093","author":[{"given":"Yaokai","family":"Wen","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou, China"},{"name":"Nanshan School, Guangzhou Medical University, Panyu District, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hengrui","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanping","family":"Qiu","sequence":"additional","affiliation":[{"name":"Nanshan School, Guangzhou Medical University, Panyu District, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhichao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiqiang","family":"Ying","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhua","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxing","family":"He","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou, 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