{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T20:53:12Z","timestamp":1770324792998,"version":"3.49.0"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2019,12,24]],"date-time":"2019-12-24T00:00:00Z","timestamp":1577145600000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002996","name":"Dutch Heart Foundation","doi-asserted-by":"publisher","award":["2013T091"],"award-info":[{"award-number":["2013T091"]}],"id":[{"id":"10.13039\/501100002996","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title\/>\n                  <jats:p\/>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>Our goal was to report the long-term serial follow-up after transatrial\u2013transpulmonary repair of tetralogy of Fallot (TOF) and to describe the influence of the timing of the repair on outcome.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>We included all patients with TOF who had undergone transatrial\u2013transpulmonary repair between 1970 and 2012. Records were reviewed for patient demographics, operative details and events during the follow-up period (death, pulmonary valve replacement, cardiac reinterventions and hospitalization\/intervention for arrhythmias). In patients with elective early primary repair of TOF after 1990, a subanalysis of the optimal timing of TOF repair was performed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>A total of 453 patients were included (63% male patients; 65% had transannular patch); 261 patients underwent primary elective repair after 1990. The median age at TOF repair was 0.7\u2009years (25th\u201375th percentile 0.3\u20131.3) and decreased from 1.7 to 0.4\u2009years from before 1990 to after 2000, respectively (P\u2009&amp;lt;\u20090.001). The median follow-up duration after TOF repair was 16.8\u2009years (9.6\u201324.7). Events developed in 182 (40%) patients. In multivariable analysis, early repair of TOF (&amp;lt;6\u2009months) [hazard ratio (HR) 3.06; P\u2009&amp;lt;\u20090.001] and complications after TOF repair (HR 2.18; P\u2009=\u20090.006) were found to be predictive for an event. In a subanalysis of the primary repair of TOF after 1990, the patients (n\u2009=\u2009125) with elective early repair (&amp;lt;6\u2009months) experienced significantly worse event-free survival compared to patients who had elective repair later (n\u2009=\u2009136). In multivariable analysis, early repair (HR 3.00; P\u2009=\u20090.001) and postoperative complications (HR 2.12; P\u2009=\u20090.010) were associated with events in electively repaired patients with TOF.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Transatrial\u2013transpulmonary repair of TOF before the age of 6\u2009months may be associated with more events during the long-term follow-up period.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejcts\/ezz331","type":"journal-article","created":{"date-parts":[[2019,11,27]],"date-time":"2019-11-27T20:10:09Z","timestamp":1574885409000},"page":"635-643","source":"Crossref","is-referenced-by-count":26,"title":["Long-term follow-up after transatrial\u2013transpulmonary repair of tetralogy of Fallot: influence of timing on outcome"],"prefix":"10.1093","volume":"57","author":[{"given":"Eva","family":"van den Bosch","sequence":"first","affiliation":[{"name":"Division of Pediatric Cardiology, Department of Pediatrics, Erasmus Medical Center, Rotterdam, Netherlands"},{"name":"Netherlands Heart Institute, Utrecht, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6200-1998","authenticated-orcid":false,"given":"Ad J J C","family":"Bogers","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic Surgery, Erasmus Medical Center, Rotterdam, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6770-3830","authenticated-orcid":false,"given":"Jolien W","family":"Roos-Hesselink","sequence":"first","affiliation":[{"name":"Department of Cardiology, Erasmus Medical Center, Rotterdam, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arie P J","family":"van Dijk","sequence":"first","affiliation":[{"name":"Department of Cardiology, Radboud University Medical Center, Nijmegen, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8415-2874","authenticated-orcid":false,"given":"Marie H E J","family":"van Wijngaarden","sequence":"first","affiliation":[{"name":"Department of Cardiology, Erasmus Medical Center, Rotterdam, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Boersma","sequence":"first","affiliation":[{"name":"Department of Cardiology, Erasmus Medical Center, Rotterdam, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2755-2767","authenticated-orcid":false,"given":"Aagje","family":"Nijveld","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic Surgery, Radboud University Medical Center, Nijmegen, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda W G","family":"Luijten","sequence":"first","affiliation":[{"name":"Division of Pediatric Cardiology, Department of Pediatrics, Erasmus Medical Center, Rotterdam, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald","family":"Tanke","sequence":"first","affiliation":[{"name":"Division of Pediatric Cardiology, Department of Pediatrics, Radboud University Medical Center, Nijmegen, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4687-4075","authenticated-orcid":false,"given":"Laurens P","family":"Koopman","sequence":"first","affiliation":[{"name":"Division of Pediatric Cardiology, Department of Pediatrics, Erasmus Medical Center, Rotterdam, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Willem A","family":"Helbing","sequence":"first","affiliation":[{"name":"Division of Pediatric Cardiology, Department of Pediatrics, Erasmus Medical Center, Rotterdam, Netherlands"},{"name":"Division of Pediatric Cardiology, Department of Pediatrics, Radboud University Medical Center, Nijmegen, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,12,23]]},"reference":[{"key":"2020031807374189700_ezz331-B1","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1016\/j.jtcvs.2012.01.076","article-title":"Tetralogy of Fallot repair: ready for a new paradigm","volume":"143","author":"Geva","year":"2012","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2020031807374189700_ezz331-B2","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1093\/ejcts\/ezu182","article-title":"Long-term outcomes of transatrial-transpulmonary repair of tetralogy of Fallot","volume":"47","author":"Luijten","year":"2015","journal-title":"Eur J Cardiothorac Surg"},{"key":"2020031807374189700_ezz331-B3","first-page":"126","article-title":"Assessment of a right-ventricular infundibulum-sparing approach in transatrial-transpulmonary repair of tetralogy of Fallot","volume":"41","author":"Bove","year":"2012","journal-title":"Eur J Cardiothorac Surg"},{"key":"2020031807374189700_ezz331-B4","doi-asserted-by":"crossref","first-page":"III-123","DOI":"10.1161\/01.CIR.102.suppl_3.III-123","article-title":"What is the optimal age for repair of tetralogy of Fallot?","volume":"102","author":"Van Arsdell","year":"2000","journal-title":"Circulation"},{"key":"2020031807374189700_ezz331-B5","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.ejcts.2010.02.030","article-title":"The long-term result of total repair for tetralogy of Fallot","volume":"38","author":"Park","year":"2010","journal-title":"Eur J Cardiothorac Surg"},{"key":"2020031807374189700_ezz331-B6","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1016\/j.athoracsur.2008.07.019","article-title":"Early primary repair of tetralogy of Fallot in neonates and infants less than four months of age","volume":"86","author":"Tamesberger","year":"2008","journal-title":"Ann Thorac Surg"},{"key":"2020031807374189700_ezz331-B7","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1007\/s00246-017-1579-8","article-title":"Complete repair of tetralogy of Fallot in the neonatal versus non-neonatal period: a meta-analysis","volume":"38","author":"Loomba","year":"2017","journal-title":"Pediatr Cardiol"},{"key":"2020031807374189700_ezz331-B8","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/BF00796817","article-title":"Relation between age at surgery and regression of right ventricular hypertrophy in tetralogy of Fallot","volume":"16","author":"Seliem","year":"1995","journal-title":"Pediatr Cardiol"},{"key":"2020031807374189700_ezz331-B9","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.jtcvs.2017.09.019","article-title":"Right ventricular outflow tract reintervention after primary tetralogy of Fallot repair in neonates and young infants","volume":"155","author":"Balasubramanya","year":"2018","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2020031807374189700_ezz331-B10","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1097\/00000658-200010000-00006","article-title":"Complete repair of tetralogy of Fallot in the neonate: results in the modern era","volume":"232","author":"Hirsch","year":"2000","journal-title":"Ann Surg"},{"key":"2020031807374189700_ezz331-B11","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.jacc.2013.10.011","article-title":"Low risk of pulmonary valve implantation after a policy of transatrial repair of tetralogy of Fallot delayed beyond the neonatal period: the Melbourne experience over 25 years","volume":"63","author":"d\u2019Udekem","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"2020031807374189700_ezz331-B12","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1093\/ejcts\/ezu401","article-title":"Need of transannular patch in tetralogy of Fallot surgery carries a higher risk of reoperation but has no impact on late survival: results of Fallot repair in Finland","volume":"48","author":"Ylitalo","year":"2015","journal-title":"Eur J Cardiothorac Surg"},{"key":"2020031807374189700_ezz331-B13","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/S0140-6736(00)02714-8","article-title":"Risk factors for arrhythmia and sudden cardiac death late after repair of tetralogy of Fallot: a multicentre study","volume":"356","author":"Gatzoulis","year":"2000","journal-title":"Lancet"},{"key":"2020031807374189700_ezz331-B14","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.athoracsur.2018.01.001","article-title":"The Society of Thoracic Surgeons congenital heart surgery database: 2018 update on outcomes and quality","volume":"105","author":"Jacobs","year":"2018","journal-title":"Ann Thorac Surg"},{"key":"2020031807374189700_ezz331-B15","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1017\/S104795111600264X","article-title":"At what age should tetralogy of Fallot be 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era","volume":"31","author":"Mouws","year":"2019","journal-title":"Semin Thorac Cardiovasc Surg"},{"key":"2020031807374189700_ezz331-B22","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1510\/icvts.2008.180083","article-title":"Is early primary repair for correction of tetralogy of Fallot comparable to surgery after 6 months of age?","volume":"7","author":"Vohra","year":"2008","journal-title":"Interact CardioVasc Thorac Surg"},{"key":"2020031807374189700_ezz331-B23","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.ejcts.2008.06.050","article-title":"Late risk of outcomes for adults with repaired tetralogy of Fallot from an inception cohort spanning four decades","volume":"35","author":"Hickey","year":"2009","journal-title":"Eur J Cardiothorac Surg"},{"key":"2020031807374189700_ezz331-B24","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/j.jtcvs.2013.11.010","article-title":"Intersurgeon variability in long-term outcomes after transatrial repair of tetralogy of Fallot: 25 years' experience with 675 patients","volume":"147","author":"d'Udekem","year":"2014","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2020031807374189700_ezz331-B25","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1161\/CIRCULATIONAHA.109.928481","article-title":"Arrhythmia burden in adults with surgically repaired tetralogy of Fallot: a multi-institutional study","volume":"122","author":"Khairy","year":"2010","journal-title":"Circulation"},{"key":"2020031807374189700_ezz331-B26","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1161\/CIRCIMAGING.111.963637","article-title":"Impact of gender and age on cardiovascular function late after repair of tetralogy of Fallot: percentiles based on cardiac magnetic resonance","volume":"4","author":"Sarikouch","year":"2011","journal-title":"Circ Cardiovasc Imaging"}],"container-title":["European Journal of Cardio-Thoracic Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/ejcts\/article-pdf\/57\/4\/635\/32925927\/ezz331.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/ejcts\/article-pdf\/57\/4\/635\/32925927\/ezz331.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,3,18]],"date-time":"2020-03-18T13:58:13Z","timestamp":1584539893000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejcts\/article\/57\/4\/635\/5686019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,23]]},"references-count":26,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2019,12,23]]},"published-print":{"date-parts":[[2020,4,1]]}},"URL":"https:\/\/doi.org\/10.1093\/ejcts\/ezz331","relation":{},"ISSN":["1010-7940","1873-734X"],"issn-type":[{"value":"1010-7940","type":"print"},{"value":"1873-734X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,4]]},"published":{"date-parts":[[2019,12,23]]}}}