{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T10:20:00Z","timestamp":1773829200717,"version":"3.50.1"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2020,1,13]],"date-time":"2020-01-13T00:00:00Z","timestamp":1578873600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>OBJECTIVES<\/jats:title>\n                  <jats:p>Failure of anastomotic healing is a morbid complication after airway or oesophageal surgery. Hyperbaric oxygen therapy (HBOT) has been used extensively in the management of complex wound-healing problems. We demonstrate the use of HBOT to rescue at-risk anastomoses or manage anastomotic failures in thoracic surgery.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Retrospective review of 25 patients who received HBOT as part of the management of tracheal or oesophageal anastomotic problems during 2007\u20132018. HBOT was delivered at 2\u2009atm with 100% oxygen in 90-min sessions.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Twenty-three patients underwent airway resection and reconstruction while 2 patients underwent oesophagectomy. There were 16 (70%) laryngotracheal and 7 (30%) tracheal resections. Necrosis at the airway anastomosis was found in 13 (57%) patients, partial dehiscence in 2 (9%) patients and both in 6 (26%) patients. HBOT was prophylactic in 2 (9%) patients. Patients received a median of 9.5 HBOT sessions (interquartile range 5\u201319 sessions) over a median course of 8\u2009days. The airway anastomosis healed in 20 of 23 (87%) patients. Overall, a satisfactory long-term airway outcome was achieved in 19 (83%) patients; 4 patients failed and required reoperation (2 tracheostomies and 1 T-tube). HBOT was used in 2 patients after oesophagectomy to manage focal necrosis or ischaemia at the anastomosis, with success in 1 patient. Complications from HBOT were infrequent and mild (e.g. ear discomfort).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>HBOT should be considered as an adjunct in the management of anastomotic problems after airway surgery. It may also play a role after oesophagectomy. Possible mechanisms of action are rapid granulation, early re-epithelialization and angiogenesis.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejcts\/ezz364","type":"journal-article","created":{"date-parts":[[2019,12,12]],"date-time":"2019-12-12T04:30:18Z","timestamp":1576125018000},"page":"1203-1209","source":"Crossref","is-referenced-by-count":13,"title":["Hyperbaric oxygen therapy in the prevention and management of tracheal and oesophageal anastomotic complications"],"prefix":"10.1093","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0064-460X","authenticated-orcid":false,"given":"Luis F","family":"Tapias","sequence":"first","affiliation":[{"name":"Division of Thoracic Surgery, Massachusetts General Hospital, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cameron D","family":"Wright","sequence":"first","affiliation":[{"name":"Division of Thoracic Surgery, Massachusetts General Hospital, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6049-1276","authenticated-orcid":false,"given":"Michael","family":"Lanuti","sequence":"first","affiliation":[{"name":"Division of Thoracic Surgery, Massachusetts General Hospital, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashok","family":"Muniappan","sequence":"first","affiliation":[{"name":"Division of Thoracic Surgery, Massachusetts General Hospital, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Deschler","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Norman Knight Hyperbaric Medicine Center, Massachusetts Eye and Ear Infirmary, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas J","family":"Mathisen","sequence":"first","affiliation":[{"name":"Division of Thoracic Surgery, Massachusetts General Hospital, Boston, MA, 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