{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T11:06:39Z","timestamp":1785927999629,"version":"3.56.0"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,1,10]],"date-time":"2023-01-10T00:00:00Z","timestamp":1673308800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Idiopathic short stature (ISS) is a diagnosis of exclusion, and therefore each child with short stature or slow growth referred to a paediatrician deserves a full medical history and physical examination, as well as radiological and laboratory screening tests. In patients with an increased likelihood of a genetic cause, genetic testing is indicated. Idiopathic short stature is an approved indication for recombinant human growth hormone (rhGH) in the USA but not in most other parts of the world. In a recent article published in this journal, Luo et al reported on the 1-year\u2019s results of a multicentre randomized controlled trial (n = 360) on the efficacy and safety of two dosages of long-acting PEGylated rhGH (PEG-rhGH, Jintrolong\u00ae) (0.1 or 0.2\u2005mg\/kg body weight per week, respectively) in children with ISS compared with an untreated control group. The growth response to the higher dosage was similar to reported data on daily rhGH. In this commentary, we discuss whether the recent data on genetic causes of short stature in children who initially were labelled ISS, and data on the long-term safety of daily rhGH, may influence the balance between risks and benefits of rhGH treatment in children with ISS. We further discuss the pharmacokinetic and -dynamic profile of PEG-rhGH and its potential consequences for long-term safety.<\/jats:p>","DOI":"10.1093\/ejendo\/lvac005","type":"journal-article","created":{"date-parts":[[2023,1,10]],"date-time":"2023-01-10T00:07:07Z","timestamp":1673309227000},"page":"R1-R4","source":"Crossref","is-referenced-by-count":7,"title":["Long-acting PEGylated growth hormone in children with idiopathic short stature: time to reconsider our diagnostic and treatment policy?"],"prefix":"10.1093","volume":"188","author":[{"given":"Jan M","family":"Wit","sequence":"first","affiliation":[{"name":"Division of Paediatric Endocrinology, Department of Paediatrics, Willem-Alexander Children\u2019s Hospital, Leiden University Medical Centre , Leiden , Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sjoerd D","family":"Joustra","sequence":"additional","affiliation":[{"name":"Division of Paediatric Endocrinology, Department of Paediatrics, 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