{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:21:06Z","timestamp":1792790466963,"version":"4.5.0"},"reference-count":63,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T00:00:00Z","timestamp":1675382400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,2,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Hypothalamic syndrome (HS) in childhood is a rare condition. Its epidemiology is not well known because incidence and prevalence are related to very rare underlying diseases. In addition, different criteria for the syndrome are used across studies. Recognizing the HS may be difficult, due to its rareness and variety of symptoms. Having diagnostic criteria for signs and symptoms of hypothalamic dysfunction may aid in early recognition and diagnosis, in the reporting and understanding of its etiology, in predicting its course and its management. We aimed to define diagnostic criteria for hypothalamic dysfunction and a score for the presence of HS in childhood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Diagnostic criteria for hypothalamic dysfunction were developed and subdivided into hyperphagia, hypophagia, body mass index, behavioral problems, sleep disorders, temperature regulation disorders, pituitary dysfunction, radiological hypothalamic assessment, and presence\/suspicion of a hypothalamic genetic syndrome. Subsequently, the scoring system was tested in a retrospective cohort of 120 patients at risk for hypothalamic dysfunction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A score for presence of HS was developed. Using this new hypothalamic score, in total 52.5% were scored as having HS. Of these patients, 76.7% were diagnosed with pituitary dysfunction, 32.5% with hyperphagia, 40% with sleep disorders, and 14.2% with temperature dysregulation. For several criteria, clinical data was missing in more than 50% of cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The here proposed diagnostic criteria for hypothalamic dysfunction and score for presence of HS may be used for care purposes and to aid in early recognition. Also it will be useful for research or registration purposes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ejendo\/lvad009","type":"journal-article","created":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T18:33:24Z","timestamp":1674671604000},"page":"214-225","source":"Crossref","is-referenced-by-count":59,"title":["Diagnostic criteria for the hypothalamic syndrome in childhood"],"prefix":"10.1093","volume":"188","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6773-6931","authenticated-orcid":false,"given":"Hanneke M","family":"van Santen","sequence":"first","affiliation":[{"name":"Department of Pediatric Endocrinology, Wilhelmina Children's Hospital, University Medical Center , Utrecht 3584 EA , The Netherlands"},{"name":"Princess M\u00e1xima Center for Pediatric Oncology , Utrecht 3584 CS , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3606-6592","authenticated-orcid":false,"given":"Jiska","family":"van Schaik","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology, Wilhelmina Children's Hospital, University Medical Center , Utrecht 3584 EA , The Netherlands"},{"name":"Princess M\u00e1xima Center for Pediatric Oncology , Utrecht 3584 CS , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1957-6750","authenticated-orcid":false,"given":"Ichelle M A A","family":"van Roessel","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology, Wilhelmina Children's Hospital, University Medical Center , Utrecht 3584 EA , The Netherlands"},{"name":"Princess M\u00e1xima Center for Pediatric Oncology , Utrecht 3584 CS , The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Beckhaus","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Pediatric Hematology\/Oncology, University Children's Hospital, Klinikum Oldenburg A\u00f6R, Carl von Ossietzky University , Oldenburg 26133 , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svenja","family":"Boekhoff","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Pediatric Hematology\/Oncology, University Children's Hospital, Klinikum Oldenburg A\u00f6R, Carl von Ossietzky University , Oldenburg 26133 , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4929-9966","authenticated-orcid":false,"given":"Hermann L","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Pediatric Hematology\/Oncology, University Children's Hospital, Klinikum Oldenburg A\u00f6R, 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