{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T18:56:05Z","timestamp":1789584965417,"version":"build-2803163510"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2023,3,3]],"date-time":"2023-03-03T00:00:00Z","timestamp":1677801600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"crossref","award":["1R01GM118653"],"award-info":[{"award-number":["1R01GM118653"]}],"id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,4,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report a unique case of a 44-year-old man with paraneoplastic hyperparathyroidism due to an oncocytic adrenocortical carcinoma (stage pT3N0R0M0, ENSAT 2 with a 4% Ki-67). Paraneoplastic hyperparathyroidism was associated with mild adrenocorticotropic hormone (ACTH)\u2013independent hypercortisolism and increased estradiol secretion responsible for gynecomastia and hypogonadism. Biological investigations performed in blood samples from peripheral and adrenal veins revealed that the tumor secreted parathyroid hormone (PTH) and estradiol. Ectopic PTH secretion was confirmed by abnormally high expression of PTH mRNA and clusters of PTH immunoreactive cells in the tumor tissue. Double-immunochemistry studies and analysis of contiguous slides for the expression of PTH and steroidogenic markers (scavenger receptor class B type 1 [SRB1], 3\u03b2-hydroxysteroid dehydrogenase [3\u03b2-HSD], and aromatase) were performed. The results suggested the presence of two tumor cells subtypes with large cells with voluminous nuclei producing only PTH and that were distinct from steroid-producing cells.<\/jats:p>","DOI":"10.1093\/ejendo\/lvad025","type":"journal-article","created":{"date-parts":[[2023,3,2]],"date-time":"2023-03-02T14:50:05Z","timestamp":1677768605000},"page":"K11-K16","source":"Crossref","is-referenced-by-count":8,"title":["Immunohistochemical characterization of a steroid-secreting oncocytic adrenal carcinoma responsible for paraneoplastic hyperparathyroidism"],"prefix":"10.1093","volume":"188","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5007-7602","authenticated-orcid":false,"given":"Magalie","family":"Haissaguerre","sequence":"first","affiliation":[{"name":"Endocrinology and Endocrine Oncology, Bordeaux University Hospital , Bordeaux 33000 , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estelle","family":"Louiset","sequence":"additional","affiliation":[{"name":"UNIROUEN, INSERM, NorDiC, Rouen, Normandie University , 76000 , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christofer C","family":"Juhlin","sequence":"additional","affiliation":[{"name":"Department of Oncology-Pathology, Karolinska Institutet , Stockholm , Sweden"},{"name":"Department of Pathology and Cancer Diagnostics, Karolinska University Hospital , Stockholm , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3248-7629","authenticated-orcid":false,"given":"Adam","family":"Stenman","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Surgery, Karolinska Institutet , Stockholm , Sweden"},{"name":"Department of Breast, Endocrine Tumors and Sarcoma, Karolinska University Hospital , Stockholm , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Laurent","sequence":"additional","affiliation":[{"name":"Digestive Surgery, Bordeaux University Hospital , Bordeaux , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Trouette","sequence":"additional","affiliation":[{"name":"Anatomopathology, Bordeaux University Hospital , Bordeaux , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herv\u00e9","family":"Lefebvre","sequence":"additional","affiliation":[{"name":"UNIROUEN, INSERM, NorDiC, Rouen, Normandie University , 76000 , France"},{"name":"Department of Endocrinology, Diabetes and Metabolic Diseases, Rouen University Hospital , Rouen , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1231-3306","authenticated-orcid":false,"given":"Antoine","family":"Tabarin","sequence":"additional","affiliation":[{"name":"Endocrinology and Endocrine Oncology, Bordeaux University Hospital , Bordeaux 33000 , France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,3,3]]},"reference":[{"issue":"3","key":"2023040504402264900_","first-page":"234","article-title":"Ectopic secretion of parathyroid hormone in a neuroendocrine tumor: a case report and review of the literature","volume":"4","author":"Kandil","year":"2011","journal-title":"Int J Clin Exp Med"},{"issue":"1","key":"2023040504402264900_","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s12022-022-09710-8","article-title":"Overview of the 2022 WHO classification of adrenal cortical 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