{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T15:57:48Z","timestamp":1785772668499,"version":"3.56.0"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T00:00:00Z","timestamp":1680134400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Else Kr\u00f6ner-Fresenius Stiftung","award":["2012_A103"],"award-info":[{"award-number":["2012_A103"]}]},{"name":"Else Kr\u00f6ner-Fresenius Stiftung","award":["2015_A228"],"award-info":[{"award-number":["2015_A228"]}]},{"name":"Clinician Scientist Program RISE"},{"name":"Else-Kr\u00f6ner-Fresenius Stiftung"},{"DOI":"10.13039\/501100007952","name":"Eva Luise und Horst K\u00f6hler Stiftung","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007952","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Charit\u00e9 Clinician Scientist Program"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,4,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Context<\/jats:title><jats:p>Patients with endogenous Cushing's syndrome (CS) may suffer from a wide range of neuropsychiatric symptoms leading to impaired quality of life (QoL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>Glucocorticoid receptor (GR) polymorphisms are associated with increased (BclI and N363S) or decreased (A3669G and ER22\/23EK) GR sensitivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>GR genotypes may modulate and affect QoL and recovery after remission differently via GR sensitivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>295 patients with endogenous CS (81 active, 214 in remission) from 3 centers of the German Cushing's Registry were included for the cross-sectional analysis. All subjects were assessed with three questionnaires (CushingQoL, Tuebingen CD-25, SF-36). For the longitudinal part, 120 patients of them were analyzed at baseline and after 1.5 \u00b1 0.9\u2005yrs of follow-up. DNA samples were obtained from peripheral blood leukocytes for GR genotyping.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients in remission scored significantly better than patients with active CS in the CushingQoL questionnaire and in the SF-36 sub-categories physical and social functioning, role-physical, bodily pain, and vitality. In cross-sectional analysis, no differences in QoL between minor allele and wildtype carriers were detected for all polymorphisms in active or cured CS. In longitudinal analysis, however, carriers with BclI minor allele showed significant improvement in SF-36 sub-categories vitality (P = .038) and mental health (P = .013) compared to wildtype carriers (active CS at baseline vs. CS in remission at follow-up). The outcome of the two questionnaires CushingQoL and Tuebingen CD-25 improved significantly in both wildtype and minor allele carriers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>BclI minor allele carriers initially had the lowest QoL but recovered better from impaired QoL than wildtype carriers.<\/jats:p><\/jats:sec>","DOI":"10.1093\/ejendo\/lvad043","type":"journal-article","created":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T00:55:55Z","timestamp":1680224155000},"page":"366-374","source":"Crossref","is-referenced-by-count":3,"title":["Glucocorticoid receptor polymorphism<i>Bcl<\/i>I with increased glucocorticoid sensitivity has a positive influence on quality of life in endogenous Cushing's syndrome in remission"],"prefix":"10.1093","volume":"188","author":[{"given":"Lara","family":"Feldkamp","sequence":"first","affiliation":[{"name":"Endocrinology in Charlottenburg , 10627 Berlin , Germany"},{"name":"Clinical Endocrinology CCM, Charit\u00e9 Universit\u00e4tsmedizin Berlin , 10117 Berlin , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik IV, Klinikum der Universit\u00e4t M\u00fcnchen , 80336 M\u00fcnchen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timo","family":"Deutschbein","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Division of Endocrinology and Diabetes, University Hospital, University of W\u00fcrzburg , 97080 W\u00fcrzburg , Germany"},{"name":"Medicover Oldenburg MVZ , 26122 Oldenburg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1490-5575","authenticated-orcid":false,"given":"Mario","family":"Detomas","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Division of Endocrinology and Diabetes, University Hospital, University of W\u00fcrzburg , 97080 W\u00fcrzburg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Hahner","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Division of Endocrinology and Diabetes, University Hospital, University of W\u00fcrzburg , 97080 W\u00fcrzburg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian J","family":"Strasburger","sequence":"additional","affiliation":[{"name":"Clinical Endocrinology CCM, Charit\u00e9 Universit\u00e4tsmedizin Berlin , 10117 Berlin , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heike","family":"K\u00fcnzel","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik IV, Klinikum der Universit\u00e4t M\u00fcnchen , 80336 M\u00fcnchen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"O\u00dfwald","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik IV, Klinikum der Universit\u00e4t M\u00fcnchen , 80336 M\u00fcnchen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4963-5184","authenticated-orcid":false,"given":"Leah","family":"Braun","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik IV, Klinikum der Universit\u00e4t M\u00fcnchen , 80336 M\u00fcnchen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7260-0748","authenticated-orcid":false,"given":"German","family":"Rubinstein","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik IV, Klinikum der Universit\u00e4t M\u00fcnchen , 80336 M\u00fcnchen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9817-9875","authenticated-orcid":false,"given":"Martin","family":"Reincke","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik IV, Klinikum der Universit\u00e4t M\u00fcnchen , 80336 M\u00fcnchen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4028-1671","authenticated-orcid":false,"given":"Marcus","family":"Quinkler","sequence":"additional","affiliation":[{"name":"Endocrinology in Charlottenburg , 10627 Berlin , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina","family":"Kienitz","sequence":"additional","affiliation":[{"name":"Endocrinology in Charlottenburg , 10627 Berlin , Germany"},{"name":"Clinical Endocrinology CCM, Charit\u00e9 Universit\u00e4tsmedizin Berlin , 10117 Berlin , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,3,30]]},"reference":[{"issue":"1","key":"2023040615495475100_","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0889-8529(05)70063-3","article-title":"Newer diagnostic techniques and problems in Cushing's disease","volume":"28","author":"Findling","year":"1999","journal-title":"Endocrinol Metab Clin North Am"},{"issue":"3","key":"2023040615495475100_","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/S0889-8529(05)70209-7","article-title":"Diagnosis and differential diagnosis of Cushing's Syndrome","volume":"30","author":"Findling","year":"2001","journal-title":"Endocrinol Metab Clin North Am"},{"issue":"2","key":"2023040615495475100_","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.ecl.2005.02.001","article-title":"Screening and diagnosis of Cushing's syndrome","volume":"34","author":"Findling","year":"2005","journal-title":"Endocrinol Metab Clin North Am"},{"issue":"10","key":"2023040615495475100_","doi-asserted-by":"crossref","first-page":"3746","DOI":"10.1210\/jc.2006-0997","article-title":"Cushing's syndrome: important issues in diagnosis and management","volume":"91","author":"Findling","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"issue":"9522","key":"2023040615495475100_","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1016\/S0140-6736(06)68699-6","article-title":"Cushing's syndrome","volume":"367","author":"Newell-Price","year":"2006","journal-title":"Lancet"},{"issue":"191","key":"2023040615495475100_","first-page":"465","article-title":"Psychiatric manifestations of Cushing's Syndrome: response to lowering of plasma cortisol","volume":"48","author":"Jeffcoate","year":"1979","journal-title":"Q J Med"},{"issue":"8","key":"2023040615495475100_","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1007\/s40265-017-0735-z","article-title":"Psychiatric symptoms in patients with Cushing's syndrome: prevalence, diagnosis and management","volume":"77","author":"Santos","year":"2017","journal-title":"Drugs"},{"issue":"3","key":"2023040615495475100_","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.ando.2018.03.007","article-title":"Quality of life in Cushing's disease: a long term issue?","volume":"79","author":"Webb","year":"2018","journal-title":"Ann Endocrinol (Paris)"},{"issue":"6","key":"2023040615495475100_","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1111\/cen.13600","article-title":"Worse health-related quality of life at long-term follow-up in patients with Cushing's Disease than patients with cortisol producing adenoma. Data from the ERCUSYN","volume":"88","author":"Valassi","year":"2018","journal-title":"Clin Endocrinol (Oxf)"},{"key":"2023040615495475100_","doi-asserted-by":"crossref","first-page":"862","DOI":"10.3389\/fendo.2019.00862","article-title":"Quality of life in patients with Cushing's Disease","volume":"10","author":"Santos","year":"2019","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"6","key":"2023040615495475100_","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1530\/EJE-13-0471","article-title":"Smaller grey matter volumes in the anterior cingulate cortex and greater cerebellar volumes in patients with long-term remission of Cushing's disease: a case-control study","volume":"169","author":"Andela","year":"2013","journal-title":"Eur J Endocrinol"},{"issue":"1","key":"2023040615495475100_","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.ecl.2014.10.013","article-title":"Health-related quality of life in pituitary diseases","volume":"44","author":"Crespo","year":"2015","journal-title":"Endocrinol Metab Clin North Am"},{"issue":"1","key":"2023040615495475100_","doi-asserted-by":"crossref","first-page":"50","DOI":"10.2174\/1872214810666160809113021","article-title":"Cushing's syndrome and steroid dementia","volume":"10","author":"Bernini","year":"2016","journal-title":"Recent Pat Endocr Metab Immune Drug Discov"},{"issue":"3","key":"2023040615495475100_","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/S0306-4530(01)00059-2","article-title":"Persistent cognitive impairment following surgical treatment of Cushing's Syndrome","volume":"27","author":"Forget","year":"2002","journal-title":"Psychoneuroendocrinology"},{"issue":"5","key":"2023040615495475100_","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1210\/jc.2004-2488","article-title":"Children experience cognitive decline despite reversal of brain atrophy one year after resolution of Cushing syndrome","volume":"90","author":"Merke","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"2023040615495475100_","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.ecl.2005.01.016","article-title":"Cognitive function and cerebral assessment in patients who have Cushing's syndrome","volume":"34","author":"Bourdeau","year":"2005","journal-title":"Endocrinol Metab Clin North Am"},{"issue":"6","key":"2023040615495475100_","doi-asserted-by":"crossref","first-page":"2699","DOI":"10.1210\/jc.2009-2032","article-title":"Subtle cognitive impairments in patients with long-term cure of Cushing's Disease","volume":"95","author":"Tiemensma","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"issue":"9","key":"2023040615495475100_","doi-asserted-by":"crossref","first-page":"E1640","DOI":"10.1210\/jc.2012-1945","article-title":"Long-term cognitive impairments and attentional deficits in patients with Cushing's disease and cortisol-producing adrenal adenoma in remission","volume":"97","author":"Ragnarsson","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"2023040615495475100_","doi-asserted-by":"crossref","first-page":"R139","DOI":"10.1530\/EJE-13-0534","article-title":"Cushing's syndrome: a structured short- and long-term management plan for patients in remission","volume":"169","author":"Ragnarsson","year":"2013","journal-title":"Eur J Endocrinol"},{"key":"2023040615495475100_","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3171\/2019.8.JNS19930","article-title":"Cushing's disease: a prospective case-control study of health-related quality of life and cognitive status before and after surgery","author":"Zarino","year":"2019","journal-title":"J Neurosurg"},{"issue":"2","key":"2023040615495475100_","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1210\/jc.2005-1058","article-title":"Long-term impaired quality of life in Cushing's syndrome despite initial improvement after surgical remission","volume":"91","author":"Lindsay","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"issue":"8","key":"2023040615495475100_","doi-asserted-by":"crossref","first-page":"e13113","DOI":"10.1111\/jne.13113","article-title":"Long-term morbidity and mortality in patients with Cushing's syndrome","volume":"34","author":"Braun","year":"2022","journal-title":"J Neuroendocrinol"},{"issue":"6","key":"2023040615495475100_","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1210\/clinem\/dgab079","article-title":"Psychotropic drugs in patients with Cushing's disease before diagnosis and at long-term follow-up: a nationwide study","volume":"106","author":"Bengtsson","year":"2021","journal-title":"J Clin Endocrinol Metab"},{"issue":"5-7","key":"2023040615495475100_","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.steroids.2005.02.006","article-title":"The human glucocorticoid receptor: one gene, multiple proteins and diverse responses","volume":"70","author":"Zhou","year":"2005","journal-title":"Steroids"},{"issue":"2-3","key":"2023040615495475100_","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.ejphar.2008.03.012","article-title":"Corticosteroid receptor-gene variants: modulators of the stress-response and implications for mental health","volume":"585","author":"Derijk","year":"2008","journal-title":"Eur J Pharmacol"},{"issue":"5","key":"2023040615495475100_","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1159\/000216192","article-title":"Single nucleotide polymorphisms related to HPA axis reactivity","volume":"16","author":"Derijk","year":"2009","journal-title":"Neuroimmunomodulation"},{"issue":"8","key":"2023040615495475100_","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.biopsych.2006.02.007","article-title":"Polymorphisms of the glucocorticoid receptor gene and major depression","volume":"59","author":"van Rossum","year":"2006","journal-title":"Biol Psychiatry"},{"issue":"6","key":"2023040615495475100_","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1210\/clinem\/dgaa105","article-title":"Accuracy of laboratory tests for the diagnosis of Cushing syndrome","volume":"105","author":"Galm","year":"2020","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"2023040615495475100_","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1530\/EJE-07-0762","article-title":"Evaluation of health-related quality of life in patients with Cushing's syndrome with a new questionnaire","volume":"158","author":"Webb","year":"2008","journal-title":"Eur J Endocrinol"},{"issue":"6","key":"2023040615495475100_","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1111\/j.1365-2265.2011.04280.x","article-title":"The development of the Tuebingen Cushing's disease quality of life inventory (Tuebingen CD-25). Part II: normative data from 1784 healthy people","volume":"76","author":"Milian","year":"2012","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"4","key":"2023040615495475100_","first-page":"190","article-title":"Monika bullinger und inge kirchberger \u201cSF-36. Fragebogen zum gesundheitszustand. handanweisung.\u201d","volume":"7","author":"Franke","year":"1998","journal-title":"Z Med Psychol"},{"issue":"1","key":"2023040615495475100_","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1210\/clinem\/dgz052","article-title":"Glucocorticoid receptor polymorphisms influence muscle strength in Cushing's syndrome","volume":"105","author":"Muller","year":"2020","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"2023040615495475100_","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1530\/EJE-16-0689","article-title":"Persistence of myopathy in Cushing's syndrome: evaluation of the German Cushing's Registry","volume":"176","author":"Berr","year":"2017","journal-title":"Eur J Endocrinol"},{"issue":"1","key":"2023040615495475100_","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1530\/EJE-11-0722","article-title":"Association of glucocorticoid receptor polymorphism A3669G with decreased risk of developing diabetes in patients with Cushing's syndrome","volume":"166","author":"Trementino","year":"2012","journal-title":"Eur J Endocrinol"},{"issue":"1","key":"2023040615495475100_","first-page":"117","article-title":"Incidence and late prognosis of Cushing's syndrome: a population-based study","volume":"86","author":"Lindholm","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"2023040615495475100_","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1111\/joim.13056","article-title":"Psychiatric and neurocognitive consequences of endogenous hypercortisolism","volume":"288","author":"Piasecka","year":"2020","journal-title":"J Inter Med"},{"issue":"5-6","key":"2023040615495475100_","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1159\/000182736","article-title":"Course of depression in Cushing's syndrome: response to treatment and comparison with Graves\u2019 disease","volume":"39","author":"Sonino","year":"1993","journal-title":"Horm Res"},{"issue":"3","key":"2023040615495475100_","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1007\/s12020-016-0963-0","article-title":"Brain metabolite abnormalities in ventromedial prefrontal cortex are related to duration of hypercortisolism and anxiety in patients with Cushing's syndrome","volume":"53","author":"Crespo","year":"2016","journal-title":"Endocrine"},{"issue":"1","key":"2023040615495475100_","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.1749-6632.2009.04981.x","article-title":"Effects of glucocorticoids on mood, memory, and the hippocampus. Treatment and preventive therapy","volume":"1179","author":"Brown","year":"2009","journal-title":"Ann N Y Acad Sci"},{"issue":"5","key":"2023040615495475100_","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1111\/j.1440-1819.2009.02005.x","article-title":"Central nervous system effects of natural and synthetic glucocorticoids","volume":"63","author":"Fietta","year":"2009","journal-title":"Psychiatry Clin Neurosci"},{"issue":"10","key":"2023040615495475100_","doi-asserted-by":"crossref","first-page":"E129","DOI":"10.1210\/jc.2010-0512","article-title":"Increased prevalence of psychopathology and maladaptive personality traits after long-term cure of Cushing's disease","volume":"95","author":"Tiemensma","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"2023040615495475100_","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s12020-016-0883-z","article-title":"Glucocorticoid receptor polymorphisms modulate cardiometabolic risk factors in patients in long-term remission of Cushing's syndrome","volume":"53","author":"Roerink","year":"2016","journal-title":"Endocrine"},{"issue":"5","key":"2023040615495475100_","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1111\/j.1365-2265.2009.03528.x","article-title":"Bcli polymorphism of the glucocorticoid receptor gene is associated with decreased bone mineral density in patients with endogenous hypercortisolism","volume":"71","author":"Szappanos","year":"2009","journal-title":"Clin Endocrinol (Oxf)"},{"key":"2023040615495475100_","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1210\/rp.59.1.333","article-title":"Polymorphisms in the glucocorticoid receptor gene and their associations with metabolic parameters and body composition","volume":"59","author":"van Rossum","year":"2004","journal-title":"Recent Prog Horm Res"},{"issue":"9","key":"2023040615495475100_","doi-asserted-by":"crossref","first-page":"E1803","DOI":"10.1210\/jc.2014-1906","article-title":"Common genetic variants in the glucocorticoid receptor and the 11beta-hydroxysteroid dehydrogenase type 1 genes influence long-term cognitive impairments in patients with Cushing's syndrome in remission","volume":"99","author":"Ragnarsson","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"2023040615495475100_","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.ejim.2015.04.013","article-title":"Muscular strength as a strong predictor of mortality: a narrative review","volume":"26","author":"Volaklis","year":"2015","journal-title":"Eur J Intern Med"}],"container-title":["European Journal of Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ejendo\/advance-article-pdf\/doi\/10.1093\/ejendo\/lvad043\/49704767\/lvad043.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ejendo\/article-pdf\/188\/4\/366\/49788994\/lvad043.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ejendo\/article-pdf\/188\/4\/366\/49788994\/lvad043.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,9]],"date-time":"2023-12-09T20:57:37Z","timestamp":1702155457000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/188\/4\/366\/7095600"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,30]]},"references-count":46,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4,5]]}},"URL":"https:\/\/doi.org\/10.1093\/ejendo\/lvad043","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,4,5]]},"published":{"date-parts":[[2023,3,30]]}}}