{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:19:19Z","timestamp":1790745559753,"version":"4.1.0"},"reference-count":108,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2023,4,12]],"date-time":"2023-04-12T00:00:00Z","timestamp":1681257600000},"content-version":"vor","delay-in-days":7,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"National Research Foundation of South Africa","award":["132503"],"award-info":[{"award-number":["132503"]}]},{"name":"Academy of Medical Sciences UK"},{"DOI":"10.13039\/100010414","name":"Health Research Board","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100010414","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Emerging Clinician Scientist Award","award":["ECSA-2020-001"],"award-info":[{"award-number":["ECSA-2020-001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,4,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>For many decades, the prevailing paradigm in endocrinology was that testosterone and 5\u03b1-dihydrotestosterone are the only potent androgens in the context of human physiology. The more recent identification of adrenal derived 11-oxygenated androgens and particularly 11-ketotestosterone have challenged these established norms, prompting a revaluation of the androgen pool, particularly in women. Since being recognized as bone fide androgens in humans, numerous studies have focused their attention on understanding the role of 11-oxygenated androgens in human health and disease and have implicated them as role players in conditions such as castration resistant prostate cancer, congenital adrenal hyperplasia, polycystic ovary syndrome, Cushing's syndrome, and premature adrenarche. This review therefore provides an overview of our current knowledge on the biosynthesis and activity of 11-oxygenated androgens with a focus on their role in disease states. We also highlight important analytical considerations for measuring this unique class of steroid hormone.<\/jats:p>","DOI":"10.1093\/ejendo\/lvad047","type":"journal-article","created":{"date-parts":[[2023,4,12]],"date-time":"2023-04-12T01:21:34Z","timestamp":1681262494000},"page":"R98-R109","source":"Crossref","is-referenced-by-count":62,"title":["The clinical and biochemical significance of 11-oxygenated androgens in human health and disease"],"prefix":"10.1093","volume":"188","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1669-6383","authenticated-orcid":false,"given":"Karl-Heinz","family":"Storbeck","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Stellenbosch University , Stellenbosch , South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9108-9105","authenticated-orcid":false,"given":"Michael W","family":"O\u2019Reilly","sequence":"additional","affiliation":[{"name":"Department of Medicine, Royal College of Surgeons in Ireland, University of Medicine and Health Sciences , Dublin , Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,4,12]]},"reference":[{"key":"2023042522103935100_lvad047-B1","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.mce.2016.08.014","article-title":"A new Dawn for androgens: novel lessons from 11-oxygenated C19 steroids","volume":"441","author":"Pretorius","year":"2017","journal-title":"Mol Cell Endocrinol."},{"key":"2023042522103935100_lvad047-B2","doi-asserted-by":"crossref","first-page":"111189","DOI":"10.1016\/j.mce.2021.111189","article-title":"Back where it belongs: 11\u03b2-hydroxyandrostenedione compels the re-assessment of C11-oxy androgens in steroidogenesis","volume":"525","author":"Barnard","year":"2021","journal-title":"Mol Cell 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