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MR\/S03658X\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000265","name":"MRC","doi-asserted-by":"publisher","award":["MR\/S019669\/1"],"award-info":[{"award-number":["MR\/S019669\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,6,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Previous studies have shown good correlation between polycystic ovarian morphology (PCOM) and serum anti-M\u00fcllerian hormone (AMH) levels. We evaluated the utility of AMH as a surrogate for PCOM as a part of the polycystic ovary syndrome (PCOS) diagnosis by describing how the use of different AMH cut-off values would change the prevalence of PCOS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A general population-based birth cohort study. Anti-M\u00fcllerian hormone concentrations were measured from serum samples taken at age 31 years (n = 2917) using the electrochemiluminescence immunoassay (Elecsys). Anti-M\u00fcllerian hormone data were combined with data on oligo\/amenorrhoea and hyperandrogenism to identify women with PCOS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The addition of AMH as a surrogate marker for PCOM increased the number of women fulfilling at least two PCOS features in accordance with the Rotterdam criteria. The prevalence of PCOS was 5.9% when using the AMH cut-off based on the 97.5% quartile (10.35\u2005ng\/mL) and 13.6% when using the recently proposed cut-off of 3.2\u2005ng\/mL. When using the latter cut-off value, the distribution of PCOS phenotypes A, B, C, and D was 23.9%, 4.7%, 36.6%, and 34.8%, respectively. Compared with the controls, all PCOS groups with different AMH concentration cut-offs showed significantly elevated testosterone (T), free androgen index (FAI), luteinizing hormone (LH), LH\/follicle-stimulating hormone (FSH) ratio, body mass index (BMI), waist circumference, and homoeostatic model assessment of insulin resistance (HOMA-IR) values, as well as significantly decreased sex hormone-binding globulin (SHBG) values.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Anti-M\u00fcllerian hormone could be useful surrogate for PCOM in large data sets, where transvaginal ultrasound is not feasible, to aid the capturing of women with typical PCOS characteristics. Anti-M\u00fcllerian hormone measurement from archived samples enables retrospective PCOS diagnosis when combined with oligo\/amenorrhoea or hyperandrogenism.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ejendo\/lvad065","type":"journal-article","created":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T16:28:55Z","timestamp":1686328135000},"page":"547-554","source":"Crossref","is-referenced-by-count":60,"title":["AMH as part of the diagnostic PCOS workup in large epidemiological studies"],"prefix":"10.1093","volume":"188","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9921-7300","authenticated-orcid":false,"given":"Terhi T","family":"Piltonen","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Medical Research Center Oulu, Research Unit of Clinical Medicine, University of Oulu and Oulu University Hospital , FI-90029, Oulu , 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Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Franks","sequence":"additional","affiliation":[{"name":"Institute of Reproductive and Developmental Biology, Imperial College London, W12 0NN , London , United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjo-Riitta","family":"J\u00e4rvelin","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Center for Life Course Health Research, University of Oulu , FI-90014, Oulu , Finland"},{"name":"Unit of Primary Care, Oulu University Hospital , FI-90220, Oulu , Finland"},{"name":"Department of Epidemiology and Biostatistics, School of Public Health, MRC Centre for Environment and Health, Imperial College London , W2 1PG, London , United Kingdom"},{"name":"Department of Life Sciences, College of Health and Life Sciences, Brunel University London , UB8 3PH, London , United 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