{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T19:43:33Z","timestamp":1790279013851,"version":"4.1.0"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T00:00:00Z","timestamp":1689811200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"2020 UIMRF Special Circumstance Grant"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Patients with acromegaly (PWA) experience balance issues, despite achieving biochemical remission, that may significantly impair their quality of life.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>We sought to assess the prevalence of falls and balance self-confidence in PWA in comparison with a control group. Furthermore, we investigated the effect of joint pain and function as predictors for their balance self-confidence.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>Cross-sectional, case-controlled<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Setting<\/jats:title>\n                  <jats:p>Tertiary care centers<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Participants<\/jats:title>\n                  <jats:p>In this case-control study, we surveyed PWA (n = 94) and nonfunctioning pituitary adenoma (PNA; n = 82) with similar age, sex, and body mass index from two Canadian centers.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Intervention(s)<\/jats:title>\n                  <jats:p>None<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main Outcome Measure(s)<\/jats:title>\n                  <jats:p>Data were obtained on number of falls during the past 12 months, self-confidence to maintain balance, joint pain, joint surgery, pain medication usage, and upper and lower extremity musculoskeletal disability.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>While both PWA and PNA had a similarly high risk of falls, PWA had lower self-confidence to maintain balance (P &amp;lt; .01). Patients with acromegaly had higher joint pain scores and more functional impairment in upper extremity, hip, knee, and ankle joints (all P &amp;lt; .01). In both groups, age, sex, and ankle functional score were predictors of balance self-confidence. For PWA, hip functional score was also a predictor of balance self-confidence in contrast to knee and back pain scores being predictors for the PNA group.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>We confirmed an increased prevalence of falls in both groups with diminished balance confidence in PWA. This reduced balance self-confidence seems to be related to their increased hip functional impairment in comparison with PNA.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejendo\/lvad090","type":"journal-article","created":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T23:23:43Z","timestamp":1689895423000},"page":"156-163","source":"Crossref","is-referenced-by-count":7,"title":["Joint pain, physical function, and balance self-confidence in acromegaly versus nonfunctioning pituitary adenoma patients"],"prefix":"10.1093","volume":"189","author":[{"given":"Michaela","family":"Title","sequence":"first","affiliation":[{"name":"Division of Kinesiology, Dalhousie University , Halifax, NS B3H 4R2 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqi","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Kinesiology, Dalhousie University , Halifax, NS B3H 4R2 , 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Ibrahim","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Western University , London, ON N2A 4V2 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stan","family":"Van Uum","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Western University , London, ON N2A 4V2 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9609-0896","authenticated-orcid":false,"given":"Constance L","family":"Chik","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, University of Alberta , Edmonton, AB T6G 2G3 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David B","family":"Clarke","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Dalhousie University , Halifax, NS B3H 3A7 , 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