{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,25]],"date-time":"2025-12-25T01:48:51Z","timestamp":1766627331396,"version":"3.37.3"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,7,21]],"date-time":"2023-07-21T00:00:00Z","timestamp":1689897600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100005709","name":"Endocrine Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005709","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Systematic assessment of skeletal muscle function is lacking in patients with nonsurgical hypoparathyroidism (HP). Whether muscle dysfunction involves respiratory muscles and results in restrictive lung disease (RLD) is not studied.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To assess skeletal muscle and pulmonary functions in patients with HP.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>Observational case\u2013control study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Thirty patients with HP (mean age 37.7 years, 60% males) and 40 age-, sex-, and body mass index (BMI)-matched healthy controls were assessed for skeletal muscle function by handgrip strength, the short physical performance battery (SPPB) test, dual-energy X-ray absorptiometry (DXA), and electromyography (EMG). Pulmonary function was assessed by spirometry, body plethysmography, diffusion lung capacity for carbon monoxide, and diaphragmatic ultrasound (DUS).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Patients with HP had lower serum calcium (2.25 \u00b1 0.15 vs 2.4 \u00b1 0.12\u2005mmol\/L, P &amp;lt; .001), serum magnesium (median [interquartile range] 0.74 [0.69-0.82] vs 0.78 [0.69-0.90] mmol\/L, P = .04), handgrip strength (18.08 \u00b1 8.36 vs 22.90 \u00b1 7.77\u2005kg, P = .01), and composite SPPB scores (9.5 [7-10] vs 12 [12-12], P &amp;lt; .001) compared to healthy controls. Electromyographic evidence of myopathy was seen in 23% (5 of 22) of patients with HP but in none of the controls (P = .08). The prevalence of RLD was higher in the HP cohort compared to that in controls (24% vs 0%, P = .01). Diaphragmatic excursion (DE) (4.22 \u00b1 1.38 vs 5.18 \u00b1 1.53\u2005cm, P = .01) and diaphragmatic thickness (DT) (3.79 \u00b1 1.18 vs 4.28 \u00b1 0.94\u2005mm, P = .05) on deep inspiration were reduced in patients with HP.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Detailed testing of patients with HP without overt muscle and lung diseases revealed significant impairment in parameters of skeletal muscle function. Myopathy and RLD were observed in a considerable proportion of patients with HP.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejendo\/lvad091","type":"journal-article","created":{"date-parts":[[2023,7,21]],"date-time":"2023-07-21T13:23:26Z","timestamp":1689945806000},"page":"141-148","source":"Crossref","is-referenced-by-count":2,"title":["Nonsurgical hypoparathyroidism is associated with skeletal muscle dysfunction and restrictive lung disease"],"prefix":"10.1093","volume":"189","author":[{"given":"Takasi Anush","family":"Babu","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences , Lucknow 226014 , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zia","family":"Hashim","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Sanjay Gandhi Postgraduate Institute of Medical Sciences , Lucknow 226014 , 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