{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T08:53:07Z","timestamp":1780649587483,"version":"3.54.1"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001254","name":"Ipsen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001254","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008005","name":"Yonsei University College of Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008005","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Korea Health Technology R&D Project"},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministry of Health & Welfare","award":["HI19C0189"],"award-info":[{"award-number":["HI19C0189"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>The results of previous studies on sex differences in mortality and comorbidities among patients with acromegaly are diverse. We assessed sex differences in mortality and the risk of complications in patients with acromegaly.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We included 1884 patients with acromegaly with 1:50 age- and sex-matched 94 200 controls using the Korean nationwide claims database from 2009 to 2019.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>During the median 5.51 years of follow-up, the acromegaly group had higher all-cause mortality than the control group (hazard ratio [HR] 1.74, 95% confidence interval [CI] 1.38-2.19), with higher risk in women than men (HR 2.17 vs 1.36). The most common cause of death was malignancy. Women with acromegaly aged \u226550 years exhibited significantly higher mortality than men with acromegaly aged \u226550 years (HR 1.74 vs 0.96). In a treatment subgroup other than surgery alone, women had a higher risk of mortality than men (HR 2.82 vs 1.58). Sex differences in mortality among patients with acromegaly remained equal after adjustment for the Charlson Comorbidity Index (CCI), socioeconomic status (SES), body mass index (BMI), alcohol consumption, smoking, fasting plasma glucose, creatinine, and total cholesterol. Patients with acromegaly had elevated risks of developing major adverse cardiovascular events (MACE), atrial fibrillation, obstructive sleep apnea (OSA), diabetes mellitus (DM), end-stage renal disease (ESRD), Parkinson's disease (PD), depression, and malignancy than age- and sex-matched controls, with a higher risk of OSA and DM in women than men.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The risk of mortality and complications in patients with acromegaly compared to age- and sex-matched controls was higher in women than in men.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejendo\/lvad106","type":"journal-article","created":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T10:41:33Z","timestamp":1691404893000},"page":"225-234","source":"Crossref","is-referenced-by-count":11,"title":["Sex differences in mortality in patients with acromegaly: a nationwide cohort study in Korea"],"prefix":"10.1093","volume":"189","author":[{"given":"Jiwon","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, National Health Insurance Service Ilsan Hospital , Goyang , Republic of Korea, 10444"},{"name":"Yonsei University Graduate School of Medicine , Seoul , Republic of Korea , 03722"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8246-1956","authenticated-orcid":false,"given":"Namki","family":"Hong","sequence":"additional","affiliation":[{"name":"Endocrinology, Department of Internal Medicine, Institute of Endocrine Research, Yonsei University College of Medicine , Seoul , Republic of Korea, 03722"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimi","family":"Choi","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University College of Medicine , Seoul , Republic of Korea, 02841"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju Hyung","family":"Moon","sequence":"additional","affiliation":[{"name":"Pituitary Tumor Center, Severance Hospital , Seoul , Republic of Korea , 03722"},{"name":"Department of Neurosurgery, Yonsei University College of Medicine , Seoul , Republic of Korea , 03722"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eui Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Pituitary Tumor Center, Severance Hospital , Seoul , Republic of Korea , 03722"},{"name":"Department of Neurosurgery, Yonsei University College of Medicine , Seoul , Republic of Korea , 03722"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Won","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Inje University Ilsan Paik Hospital, Inje University College of Medicine , Goyang , Republic of Korea, 10380"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9876-8370","authenticated-orcid":false,"given":"Eun Jig","family":"Lee","sequence":"additional","affiliation":[{"name":"Endocrinology, Department of Internal Medicine, Institute of Endocrine Research, Yonsei University College of Medicine , Seoul , Republic of Korea, 03722"},{"name":"Pituitary Tumor Center, Severance Hospital , Seoul , Republic of Korea , 03722"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7430-3675","authenticated-orcid":false,"given":"Sin Gon","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University College of Medicine , Seoul , Republic of Korea, 02841"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8693-9630","authenticated-orcid":false,"given":"Cheol Ryong","family":"Ku","sequence":"additional","affiliation":[{"name":"Endocrinology, Department of Internal Medicine, Institute of Endocrine Research, Yonsei University College of Medicine , Seoul , Republic of Korea, 03722"},{"name":"Pituitary Tumor Center, Severance Hospital , Seoul , Republic of Korea , 03722"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,8,7]]},"reference":[{"issue":"1","key":"2023081713373089700_lvad106-B1","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/s41572-019-0071-6","article-title":"Acromegaly","volume":"5","author":"Colao","year":"2019","journal-title":"Nat Rev Dis Primers"},{"issue":"24","key":"2023081713373089700_lvad106-B2","doi-asserted-by":"crossref","first-page":"2558","DOI":"10.1056\/NEJMra062453","article-title":"Medical progress: acromegaly","volume":"355","author":"Melmed","year":"2006","journal-title":"N Engl J Med"},{"issue":"1","key":"2023081713373089700_lvad106-B3","doi-asserted-by":"crossref","first-page":"c4189","DOI":"10.1136\/bmj.c4189","article-title":"Acromegaly","volume":"341","author":"Reddy","year":"2010","journal-title":"BMJ"},{"issue":"2","key":"2023081713373089700_lvad106-B4","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1530\/EJE-12-0084","article-title":"Predictors of morbidity and mortality in acromegaly: an Italian survey","volume":"167","author":"Arosio","year":"2012","journal-title":"Eur J Endocrinol"},{"issue":"11","key":"2023081713373089700_lvad106-B5","doi-asserted-by":"crossref","first-page":"4216","DOI":"10.1210\/jc.2009-1097","article-title":"ACTH deficiency, higher doses of hydrocortisone replacement, and radiotherapy are independent predictors of mortality in patients with acromegaly","volume":"94","author":"Sherlock","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"2023081713373089700_lvad106-B6","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1530\/ERC-16-0106","article-title":"Mortality in acromegaly: a 20-year follow-up study","volume":"23","author":"Ritvonen","year":"2016","journal-title":"Endocr Relat Cancer"},{"issue":"5","key":"2023081713373089700_lvad106-B7","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1530\/EJE-18-0015","article-title":"Decreasing mortality and changes in treatment patterns in patients with acromegaly from a nationwide study","volume":"178","author":"Esposito","year":"2018","journal-title":"Eur J Endocrinol"},{"issue":"4","key":"2023081713373089700_lvad106-B8","doi-asserted-by":"crossref","first-page":"dgz317","DOI":"10.1210\/clinem\/dgz317","article-title":"Risk for acromegaly-related comorbidities by sex in Korean acromegaly","volume":"105","author":"Park","year":"2020","journal-title":"J Clin Endocrinol Metab"},{"issue":"10","key":"2023081713373089700_lvad106-B9","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1530\/ERC-17-0253","article-title":"Acromegaly at diagnosis in 3173 patients from the Liege Acromegaly Survey (LAS) Database","volume":"24","author":"Petrossians","year":"2017","journal-title":"Endocr Relat Cancer"},{"issue":"11","key":"2023081713373089700_lvad106-B10","doi-asserted-by":"crossref","first-page":"3997","DOI":"10.1210\/jc.2016-1937","article-title":"The Mexican Acromegaly Registry: clinical and biochemical characteristics at diagnosis and therapeutic outcomes","volume":"101","author":"Portocarrero-Ortiz","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"2023081713373089700_lvad106-B11","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1210\/jc.2018-00325","article-title":"Persistence of diabetes and hypertension after multimodal treatment of acromegaly","volume":"103","author":"Gonzalez","year":"2018","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"2023081713373089700_lvad106-B12","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1111\/j.1365-2265.1987.tb00805.x","article-title":"Acromegaly","volume":"26","author":"Nabarro","year":"1987","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"3","key":"2023081713373089700_lvad106-B13","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1530\/EJE-13-0166","article-title":"Comparison of the effects of primary somatostatin analogue therapy and pituitary adenomectomy on survival in patients with acromegaly: a retrospective cohort study","volume":"169","author":"Bogazzi","year":"2013","journal-title":"Eur J Endocrinol"},{"issue":"12","key":"2023081713373089700_lvad106-B14","doi-asserted-by":"crossref","first-page":"4438","DOI":"10.1210\/jc.2014-2670","article-title":"Successful mortality reduction and control of comorbidities in patients with acromegaly followed at a highly specialized multidisciplinary clinic","volume":"99","author":"Mercado","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"2023081713373089700_lvad106-B15","doi-asserted-by":"crossref","first-page":"R67","DOI":"10.1530\/EJE-19-1023","article-title":"Management of endocrine disease: does gender matter in the management of acromegaly?","volume":"182","author":"Lenders","year":"2020","journal-title":"Eur J Endocrinol"},{"issue":"1","key":"2023081713373089700_lvad106-B16","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1111\/cen.14750","article-title":"Sex difference in patients with controlled acromegaly\u2014a multicentre survey","volume":"98","author":"Dal","year":"2023","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"5","key":"2023081713373089700_lvad106-B17","doi-asserted-by":"crossref","first-page":"395","DOI":"10.4093\/dmj.2014.38.5.395","article-title":"Background and data configuration process of a nationwide population-based study using the Korean national health insurance system","volume":"38","author":"Song","year":"2014","journal-title":"Diabetes Metab J"},{"issue":"2","key":"2023081713373089700_lvad106-B18","first-page":"e15","article-title":"Cohort profile: the national health insurance service-national sample cohort (NHIS-NSC), South Korea","volume":"46","author":"Lee","year":"2017","journal-title":"Int J Epidemiol"},{"issue":"12","key":"2023081713373089700_lvad106-B19","doi-asserted-by":"crossref","first-page":"4769","DOI":"10.1210\/jc.2006-1668","article-title":"High prevalence of pituitary adenomas: a cross-sectional study in the province of Liege, Belgium","volume":"91","author":"Daly","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"2023081713373089700_lvad106-B20","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1111\/j.1365-2265.2009.03667.x","article-title":"Prevalence of pituitary adenomas: a community-based, cross-sectional study in Banbury (Oxfordshire, UK)","volume":"72","author":"Fernandez","year":"2010","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"2","key":"2023081713373089700_lvad106-B21","doi-asserted-by":"crossref","first-page":"101264","DOI":"10.1016\/j.beem.2019.02.001","article-title":"National acromegaly registries","volume":"33","author":"Maione","year":"2019","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"issue":"6","key":"2023081713373089700_lvad106-B22","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1007\/s11102-015-0655-4","article-title":"The incidence and prevalence of acromegaly, a nationwide study from 1955 through 2013","volume":"18","author":"Hoskuldsdottir","year":"2015","journal-title":"Pituitary"},{"issue":"2","key":"2023081713373089700_lvad106-B23","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1007\/s11102-021-01198-5","article-title":"Prevalence of comorbidities and concomitant medication use in acromegaly: analysis of real-world data from the United States","volume":"25","author":"Fleseriu","year":"2022","journal-title":"Pituitary"},{"issue":"1","key":"2023081713373089700_lvad106-B24","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1530\/EJE-18-0255","article-title":"Mortality in acromegaly decreased in the last decade: a systematic review and meta-analysis","volume":"179","author":"Bolfi","year":"2018","journal-title":"Eur J Endocrinol"},{"issue":"8","key":"2023081713373089700_lvad106-B25","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/S2213-8587(22)00160-7","article-title":"Risk of second brain tumour after radiotherapy for pituitary adenoma or craniopharyngioma: a retrospective, multicentre, cohort study of 3679 patients with long-term imaging surveillance","volume":"10","author":"Hamblin","year":"2022","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"4","key":"2023081713373089700_lvad106-B26","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.wneu.2014.12.009","article-title":"Radiation-induced malignant gliomas: a current review","volume":"83","author":"Elsamadicy","year":"2015","journal-title":"World Neurosurg"},{"issue":"3","key":"2023081713373089700_lvad106-B27","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1210\/jc.2016-3402","article-title":"Radiotherapy, especially at young age, increases the risk for de novo brain tumors in patients treated for pituitary\/sellar lesions","volume":"102","author":"Burman","year":"2017","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"2023081713373089700_lvad106-B28","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1023\/A:1015713732717","article-title":"Acromegaly and cancer risk: a cohort study in Sweden and Denmark","volume":"13","author":"Baris","year":"2002","journal-title":"Cancer Causes Control"},{"issue":"22","key":"2023081713373089700_lvad106-B29","doi-asserted-by":"crossref","first-page":"3484","DOI":"10.3748\/wjg.14.3484","article-title":"Risk of colorectal neoplasm in patients with acromegaly: a meta-analysis","volume":"14","author":"Rokkas","year":"2008","journal-title":"World J Gastroenterol"},{"issue":"1","key":"2023081713373089700_lvad106-B30","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1210\/jc.2004-0240","article-title":"Colonoscopic screening and follow-up in patients with acromegaly: a multicenter study in Italy","volume":"90","author":"Terzolo","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"2023081713373089700_lvad106-B31","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.beem.2017.03.003","article-title":"Sex steroids and the GH axis: implications for the management of hypopituitarism","volume":"31","author":"Birzniece","year":"2017","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"issue":"4","key":"2023081713373089700_lvad106-B32","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1111\/j.1365-2265.2006.02676.x","article-title":"Modulation of growth hormone action by sex steroids","volume":"65","author":"Meinhardt","year":"2006","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"9","key":"2023081713373089700_lvad106-B33","doi-asserted-by":"crossref","first-page":"dgaa405","DOI":"10.1210\/clinem\/dgaa405","article-title":"Disease control and gender predict the socioeconomic effects of acromegaly: a nationwide cohort study","volume":"105","author":"Dal","year":"2020","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"2023081713373089700_lvad106-B34","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1007\/s11102-015-0702-1","article-title":"Diagnosis and management of acromegaly: the patient's perspective","volume":"19","author":"Kreitschmann-Andermahr","year":"2016","journal-title":"Pituitary"},{"issue":"6","key":"2023081713373089700_lvad106-B35","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1530\/EJE-20-0019","article-title":"Prolonged diagnostic delay in acromegaly is associated with increased morbidity and mortality","volume":"182","author":"Esposito","year":"2020","journal-title":"Eur J Endocrinol"},{"issue":"3","key":"2023081713373089700_lvad106-B36","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1210\/clinem\/dgaa859","article-title":"Discordant GH and IGF-1 results in treated acromegaly: impact of GH cutoffs and mean values assessment","volume":"106","author":"Campana","year":"2021","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"2023081713373089700_lvad106-B37","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1530\/EJE-11-0098","article-title":"Clinical and metabolic characteristics of acromegalic patients with high IGF1\/normal GH levels during somatostatin analog treatment","volume":"164","author":"Matta","year":"2011","journal-title":"Eur J Endocrinol"},{"issue":"15","key":"2023081713373089700_lvad106-B38","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1093\/eurheartj\/ehab822","article-title":"Acromegaly and cardiovascular outcomes: a cohort study","volume":"43","author":"Hong","year":"2022","journal-title":"Eur Heart J"},{"issue":"6","key":"2023081713373089700_lvad106-B39","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1530\/EJE-10-0007","article-title":"The kidney in acromegaly: renal structure and function in patients with acromegaly during active disease and 1 year after disease remission","volume":"162","author":"Auriemma","year":"2010","journal-title":"Eur J Endocrinol"},{"issue":"8","key":"2023081713373089700_lvad106-B40","doi-asserted-by":"crossref","first-page":"2511","DOI":"10.1007\/s00467-021-05097-6","article-title":"Renal effects of growth hormone in health and in kidney disease","volume":"36","author":"Haffner","year":"2021","journal-title":"Pediatr Nephrol"},{"issue":"2","key":"2023081713373089700_lvad106-B41","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1179\/016164104225013851","article-title":"The multifunctional role of IGF-1 in peripheral nerve regeneration","volume":"26","author":"Rabinovsky","year":"2004","journal-title":"Neurol Res"},{"issue":"21","key":"2023081713373089700_lvad106-B42","doi-asserted-by":"crossref","first-page":"2148","DOI":"10.1212\/WNL.0b013e3182752eef","article-title":"Insulin-like growth factors in the brain and their potential clinical implications","volume":"79","author":"Benarroch","year":"2012","journal-title":"Neurology"},{"issue":"8","key":"2023081713373089700_lvad106-B43","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1007\/BF03346653","article-title":"Growth hormone\/insulin-like growth factor I axis in neurodegenerative diseases","volume":"33","author":"Gasperi","year":"2010","journal-title":"J Endocrinol Invest"},{"issue":"9","key":"2023081713373089700_lvad106-B44","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1016\/j.metabol.2016.05.018","article-title":"Role of metabolism in neurodegenerative disorders","volume":"65","author":"Procaccini","year":"2016","journal-title":"Metab Clin Exp."},{"issue":"5","key":"2023081713373089700_lvad106-B45","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1136\/jnnp.2009.175752","article-title":"Increased serum insulin-like growth factor 1 in early idiopathic Parkinson's disease","volume":"81","author":"Godau","year":"2010","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"5","key":"2023081713373089700_lvad106-B46","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.jocn.2009.08.013","article-title":"Expression of insulin-like growth factor-1 and insulin-like growth factor binding proteins in the serum and cerebrospinal fluid of patients with Parkinson\u2019s disease","volume":"17","author":"Mashayekhi","year":"2010","journal-title":"J Clin Neurosci"},{"issue":"3","key":"2023081713373089700_lvad106-B47","doi-asserted-by":"crossref","first-page":"e0150552","DOI":"10.1371\/journal.pone.0150552","article-title":"Insulin-like growth factor 1 (IGF-1) in Parkinson\u2019s disease: potential as trait-, progression- and prediction marker and confounding factors","volume":"11","author":"Bernhard","year":"2016","journal-title":"PLoS One"},{"issue":"12","key":"2023081713373089700_lvad106-B48","doi-asserted-by":"crossref","first-page":"e0144755","DOI":"10.1371\/journal.pone.0144755","article-title":"Serum insulin-like growth factor-1 in patients with de novo, drug naive Parkinson\u2019s disease: a meta-analysis","volume":"10","author":"Li","year":"2015","journal-title":"PLoS One"},{"key":"2023081713373089700_lvad106-B49","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.0000000000201010","article-title":"The risk of neurodegenerative diseases in patients with acromegaly: a cohort study","author":"Hong","year":"2022","journal-title":"Neurology"},{"issue":"4","key":"2023081713373089700_lvad106-B50","doi-asserted-by":"crossref","first-page":"e60041","DOI":"10.1371\/journal.pone.0060041","article-title":"Neurocognitive function in acromegaly after surgical resection of GH-secreting adenoma versus naive acromegaly","volume":"8","author":"Martin-Rodriguez","year":"2013","journal-title":"PLoS One"},{"issue":"9204","key":"2023081713373089700_lvad106-B51","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/S0140-6736(99)04055-6","article-title":"Incidence of diabetes mellitus and impaired glucose tolerance in children and adolescents receiving growth-hormone treatment","volume":"355","author":"Cutfield","year":"2000","journal-title":"Lancet"},{"issue":"6","key":"2023081713373089700_lvad106-B52","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1507\/endocrj.K09E-342","article-title":"Gender differences in serum GH and IGF-I levels and the GH response to dynamic tests in patients with acromegaly","volume":"57","author":"Tanaka","year":"2010","journal-title":"Endocr J"},{"issue":"3","key":"2023081713373089700_lvad106-B53","doi-asserted-by":"crossref","first-page":"e532","DOI":"10.1210\/clinem\/dgz187","article-title":"Biochemical control in acromegaly with multimodality therapies: outcomes from a pituitary center and changes over time","volume":"105","author":"Ghajar","year":"2020","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"2023081713373089700_lvad106-B54","first-page":"111","article-title":"Risk of neoplasms in acromegaly","volume":"16","author":"Ruchala","year":"2012","journal-title":"Contemp Oncol (Pozn)"}],"container-title":["European Journal of Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ejendo\/advance-article-pdf\/doi\/10.1093\/ejendo\/lvad106\/51046570\/lvad106.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ejendo\/article-pdf\/189\/2\/225\/51124989\/lvad106.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ejendo\/article-pdf\/189\/2\/225\/51124989\/lvad106.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T16:28:28Z","timestamp":1692289708000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/189\/2\/225\/7238044"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":54,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,8,2]]}},"URL":"https:\/\/doi.org\/10.1093\/ejendo\/lvad106","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,8]]},"published":{"date-parts":[[2023,8]]}}}