{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T23:39:12Z","timestamp":1790033952060,"version":"4.0.1"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,8,4]],"date-time":"2023-08-04T00:00:00Z","timestamp":1691107200000},"content-version":"vor","delay-in-days":3,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["SNF-199391"],"award-info":[{"award-number":["SNF-199391"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["SNF-162608"],"award-info":[{"award-number":["SNF-162608"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Young Talents in Clinical Research"},{"DOI":"10.13039\/501100008485","name":"Swiss Academy of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008485","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005688","name":"G. & J. Bangerter-Rhyner Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005688","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Goldschmidt Jacobson Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Importance<\/jats:title>\n                  <jats:p>The syndrome of inappropriate antidiuresis (SIAD) can be treated with oral urea; however, compliance is impaired by its poor palatability.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To investigate whether dietary proteins could increase plasma sodium levels through urea-induced osmotic diuresis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>An open-label, proof-of-concept trial.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Setting<\/jats:title>\n                  <jats:p>University Hospital of Basel, Switzerland, between October 2021 and February 2023.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Participants<\/jats:title>\n                  <jats:p>Outpatients with chronic SIAD.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Interventions or exposures<\/jats:title>\n                  <jats:p>Ninety grams of protein daily for 7\u2005days in the form of protein powder, followed by 30\u2005g of oral urea daily for 7\u2005days after a wash-out period of \u22651 week.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main outcomes and measures<\/jats:title>\n                  <jats:p>The increase in sodium levels from baseline to the end of the 7-day protein supplementation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Seventeen patients were included. After 7\u2005days of 90\u2005g daily protein supplementation (n = 17), plasma sodium levels increased from 131 (129-133) to 133 (132-137), that is, by a median of 3 mmol L\u20131 (0-5) (P = .01). Plasma urea levels increased by 3 mmol L\u20131 (1.7-4.9) (P &amp;lt; .01), and urine urea to creatinine ratio increased by 21.2 mmol mmol\u20131 (6.2-29.1) (P &amp;lt; .01). After 7 days of 30 g oral urea (n = 10), plasma sodium levels increased from 132 (130-133) to 134 (131-136), that is, by a median of 2 mmol L\u20131 (1-3) (P = .06). Plasma urea levels increased by 5.8 mmol L\u20131 (2.7-9.2) (P &amp;lt; .01), and urine urea to creatinine ratio increased by 31.0 mmol mmol\u20131 (18.7-45.1) (P &amp;lt; .01).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions and relevance<\/jats:title>\n                  <jats:p>Our findings suggest that protein powder increases plasma sodium levels in patients with chronic SIAD through protein-induced ureagenesis and osmotic diuresis. The effects are comparable with oral urea.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejendo\/lvad108","type":"journal-article","created":{"date-parts":[[2023,8,4]],"date-time":"2023-08-04T21:54:36Z","timestamp":1691186076000},"page":"252-261","source":"Crossref","is-referenced-by-count":19,"title":["Effect of protein supplementation on plasma sodium levels in the syndrome of inappropriate antidiuresis: a monocentric, open-label, proof-of-concept study\u2014the TREASURE study"],"prefix":"10.1093","volume":"189","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0179-7889","authenticated-orcid":false,"given":"Sophie","family":"Monnerat","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Diabetology and Metabolism, University Hospital Basel , Basel , Switzerland"},{"name":"Department of Clinical Research, University of Basel , Basel , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5442-7304","authenticated-orcid":false,"given":"Cihan","family":"Atila","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetology and Metabolism, University Hospital Basel , Basel , Switzerland"},{"name":"Department of Clinical Research, University of Basel , Basel , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabienne","family":"Baur","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetology and Metabolism, University Hospital Basel , Basel , Switzerland"},{"name":"Department of Clinical Research, University of Basel , Basel , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyce","family":"Santos de Jesus","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetology and Metabolism, University Hospital Basel , Basel , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3040-4685","authenticated-orcid":false,"given":"Julie","family":"Refardt","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetology and Metabolism, University Hospital Basel , Basel , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Dickenmann","sequence":"additional","affiliation":[{"name":"Clinic for Transplantation Immunology and Nephrology, University Hospital Basel , Basel , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6336-0965","authenticated-orcid":false,"given":"Mirjam","family":"Christ-Crain","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetology and Metabolism, University Hospital Basel , Basel , Switzerland"},{"name":"Department of Clinical Research, University of Basel , Basel , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,8,4]]},"reference":[{"key":"2023082522372521400_lvad108-B1","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1159\/000493234","volume-title":"Disorders of Fluid and Electrolyte Metabolism\u2014Focus on Hyponatremia","author":"Burst","year":"2019"},{"issue":"12","key":"2023082522372521400_lvad108-B2","doi-asserted-by":"crossref","first-page":"e80451","DOI":"10.1371\/journal.pone.0080451","article-title":"Moderate hyponatremia is associated with increased risk of mortality: evidence from a meta-analysis","volume":"8","author":"Corona","year":"2013","journal-title":"PLoS One"},{"issue":"1","key":"2023082522372521400_lvad108-B3","doi-asserted-by":"crossref","first-page":"71.e1","DOI":"10.1016\/j.amjmed.2005.09.026","article-title":"Mild chronic hyponatremia is associated with falls, unsteadiness, and attention deficits","volume":"119","author":"Renneboog","year":"2006","journal-title":"Am J Med"},{"issue":"2","key":"2023082522372521400_lvad108-B4","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1681\/ASN.2022050623","article-title":"Treatment effect of the SGLT2 inhibitor empagliflozin on chronic syndrome of inappropriate antidiuresis: results of a randomized, double-blind, placebo-controlled, crossover trial","volume":"34","author":"Refardt","year":"2023","journal-title":"J Am Soc Nephrol"},{"issue":"8","key":"2023082522372521400_lvad108-B5","doi-asserted-by":"crossref","first-page":"3021","DOI":"10.1210\/jc.2015-1261","article-title":"Hyponatremia is associated with increased osteoporosis and bone fractures in a large US health system population","volume":"100","author":"Usala","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"2023082522372521400_lvad108-B6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1530\/EJE-21-0604","article-title":"Effect of hyponatremia normalization on osteoblast function in patients with SIAD","volume":"186","author":"Potasso","year":"2021","journal-title":"Eur J Endocrinol"},{"issue":"4","key":"2023082522372521400_lvad108-B7","doi-asserted-by":"crossref","first-page":"e0124105","DOI":"10.1371\/journal.pone.0124105","article-title":"Hyponatremia improvement is associated with a reduced risk of mortality: evidence from a meta-analysis","volume":"10","author":"Corona","year":"2015","journal-title":"PLoS One"},{"issue":"1","key":"2023082522372521400_lvad108-B8","doi-asserted-by":"crossref","first-page":"12526","DOI":"10.1038\/s41598-019-49054-8","article-title":"Impact of resolution of hyponatremia on neurocognitive and motor performance in geriatric patients","volume":"9","author":"Brinkkoetter","year":"2019","journal-title":"Sci Rep"},{"issue":"4","key":"2023082522372521400_lvad108-B9","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1111\/eci.12597","article-title":"Impact of hyponatremia on nerve conduction and muscle strength","volume":"46","author":"Vandergheynst","year":"2016","journal-title":"Eur J Clin Invest"},{"issue":"6","key":"2023082522372521400_lvad108-B10","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1111\/cen.13128","article-title":"The contribution of undiagnosed adrenal insufficiency to euvolaemic hyponatraemia: results of a large prospective single-centre study","volume":"85","author":"Cuesta","year":"2016","journal-title":"Clin Endocrinol"},{"issue":"7","key":"2023082522372521400_lvad108-B11","doi-asserted-by":"crossref","first-page":"S36","DOI":"10.1016\/j.amjmed.2006.05.006","article-title":"Regulation of arginine vasopressin in the syndrome of inappropriate antidiuresis","volume":"119","author":"Robertson","year":"2006","journal-title":"Am J Med"},{"issue":"20","key":"2023082522372521400_lvad108-B12","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1056\/NEJMcp066837","article-title":"The syndrome of inappropriate antidiuresis","volume":"356","author":"Ellison","year":"2007","journal-title":"N Engl J Med"},{"issue":"12","key":"2023082522372521400_lvad108-B13","doi-asserted-by":"crossref","first-page":"e4360","DOI":"10.1210\/clinem\/dgaa619","article-title":"Fluid restriction therapy for chronic SIAD; results of a prospective randomized controlled trial","volume":"105","author":"Garrahy","year":"2020","journal-title":"J Clin Endocrinol Metab"},{"issue":"20","key":"2023082522372521400_lvad108-B14","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1056\/NEJMoa065181","article-title":"Tolvaptan, a selective oral vasopressin V2-receptor antagonist, for hyponatremia","volume":"355","author":"Schrier","year":"2006","journal-title":"N Engl J Med"},{"issue":"3","key":"2023082522372521400_lvad108-B15","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1681\/ASN.2019090944","article-title":"A randomized trial of empagliflozin to increase plasma sodium levels in patients with the syndrome of inappropriate antidiuresis","volume":"31","author":"Refardt","year":"2020","journal-title":"J Am Soc Nephrol"},{"issue":"1-2","key":"2023082522372521400_lvad108-B16","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1159\/000503773","article-title":"Urea for chronic hyponatremia","volume":"49","author":"Rondon-Berrios","year":"2020","journal-title":"Blood Purif."},{"issue":"4","key":"2023082522372521400_lvad108-B17","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1111\/cen.13930","article-title":"Urea treatment in fluid restriction-refractory hyponatraemia","volume":"90","author":"Lockett","year":"2019","journal-title":"Clin Endocrinol"},{"issue":"5","key":"2023082522372521400_lvad108-B18","doi-asserted-by":"crossref","first-page":"742","DOI":"10.2215\/CJN.06990711","article-title":"Efficacy and tolerance of urea compared with vaptans for long-term treatment of patients with SIADH","volume":"7","author":"Soupart","year":"2012","journal-title":"Clin J Am Soc Nephrol"},{"issue":"3","key":"2023082522372521400_lvad108-B19","doi-asserted-by":"crossref","first-page":"G1","DOI":"10.1530\/EJE-13-1020","article-title":"Clinical practice guideline on diagnosis and treatment of hyponatraemia","volume":"170","author":"Spasovski","year":"2014","journal-title":"Eur J Endocrinol"},{"issue":"1","key":"2023082522372521400_lvad108-B20","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/0026-0495(88)90028-5","article-title":"Effect of protein intake and urea on sodium excretion during inappropriate antidiuresis in rats","volume":"37","author":"Verbalis","year":"1988","journal-title":"Metab Clin Exp."},{"issue":"5","key":"2023082522372521400_lvad108-B21","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1210\/jc.2012-3225","article-title":"Severe hypernatremia from a urea-induced diuresis due to body protein wasting in an insulin-resistant type 2 diabetic patient","volume":"98","author":"Anderson","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"2023082522372521400_lvad108-B22","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1093\/ndt\/gfr428","article-title":"Osmotic diuresis due to urea as the cause of hypernatraemia in critically ill patients","volume":"27","author":"Lindner","year":"2012","journal-title":"Nephrology Dial Transplant"},{"issue":"2","key":"2023082522372521400_lvad108-B23","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.beem.2016.02.009","article-title":"The syndrome of inappropriate antidiuresis (SIAD)","volume":"30","author":"Cuesta","year":"2016","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"2023082522372521400_lvad108-B24","volume-title":"Factors for Converting Percentages of Nitrogen in Foods and Feeds into Percentages of Proteins","author":"Jones","year":"1931"},{"issue":"6","key":"2023082522372521400_lvad108-B25","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1002\/sim.721","article-title":"Sample size tables for exact single-stage phase II designs","volume":"20","author":"A'Hern","year":"2001","journal-title":"Stat Med"},{"issue":"4","key":"2023082522372521400_lvad108-B26","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/S0002-9629(15)40736-0","article-title":"The urine\/plasma electrolyte ratio: a predictive guide to water restriction","volume":"319","author":"Furst","year":"2000","journal-title":"Am J Med Sci"},{"key":"2023082522372521400_lvad108-B27","volume-title":"R: A Language and Environment for Statistical Computing","author":"R Core Team","year":"2022"},{"issue":"2","key":"2023082522372521400_lvad108-B28","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1053\/j.akdh.2022.11.004","article-title":"Hyponatremia demystified: integrating physiology to shape clinical practice","volume":"30","author":"Workeneh","year":"2022","journal-title":"Adv Kidney Dis Health"},{"issue":"4","key":"2023082522372521400_lvad108-B29","doi-asserted-by":"crossref","first-page":"233","DOI":"10.5414\/CN110518","article-title":"Variations in daily urine solute output in patients with NDI, CDI, SIADH, and NSIAD: clinical implications","volume":"96","author":"Decaux","year":"2021","journal-title":"Clin Nephrol"},{"key":"2023082522372521400_lvad108-B30","doi-asserted-by":"crossref","DOI":"10.1177\/20420188221097343","article-title":"The management of acute and chronic hyponatraemia","volume":"13","author":"Lawless","year":"2022","journal-title":"Ther Adv Endocrinol Metab."},{"issue":"10","key":"2023082522372521400_lvad108-B31","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.amjmed.2013.07.006","article-title":"Diagnosis, evaluation, and treatment of hyponatremia: expert panel recommendations","volume":"126","author":"Verbalis","year":"2013","journal-title":"Am J Med"},{"issue":"5","key":"2023082522372521400_lvad108-B32","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1530\/EJE-10-1078","article-title":"Efficacy and safety of oral tolvaptan therapy in patients with the syndrome of inappropriate antidiuretic hormone secretion","volume":"164","author":"Verbalis","year":"2011","journal-title":"Eur J Endocrinol"},{"issue":"2","key":"2023082522372521400_lvad108-B33","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/s42000-023-00430-0","article-title":"Long-term efficacy of empagliflozin as an add-on treatment for chronic SIAD: a case report and literature review","volume":"22","author":"Bioletto","year":"2023","journal-title":"Hormones"},{"issue":"2","key":"2023082522372521400_lvad108-B34","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/ki.2015.138","article-title":"Salt-sparing diuretic action of a water-soluble urea analog inhibitor of urea transporters UT-A and UT-B in rats","volume":"88","author":"Cil","year":"2015","journal-title":"Kidney Int"},{"issue":"1","key":"2023082522372521400_lvad108-B35","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1002\/jcsm.12048","article-title":"SARC-F: a symptom score to predict persons with sarcopenia at risk for poor functional outcomes","volume":"7","author":"Malmstrom","year":"2016","journal-title":"J Cachexia Sarcopenia Muscle."},{"issue":"2","key":"2023082522372521400_lvad108-B36","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s11357-011-9347-9","article-title":"Chronic hyponatremia exacerbates multiple manifestations of senescence in male rats","volume":"35","author":"Barsony","year":"2013","journal-title":"Age (Dordr)"},{"issue":"1","key":"2023082522372521400_lvad108-B37","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s12877-020-01955-4","article-title":"Mild hyponatremia is associated with low skeletal muscle mass, physical function impairment, and depressive mood in the elderly","volume":"21","author":"Fujisawa","year":"2021","journal-title":"BMC Geriatr."},{"issue":"11","key":"2023082522372521400_lvad108-B38","doi-asserted-by":"crossref","first-page":"e13022","DOI":"10.1111\/eci.13022","article-title":"Impact of chronic hyponatremia on neurocognitive and neuromuscular function","volume":"48","author":"Refardt","year":"2018","journal-title":"Euro J Clin Invest"},{"issue":"11","key":"2023082522372521400_lvad108-B39","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1016\/j.jamda.2016.08.009","article-title":"Impacts of high-protein oral nutritional supplements among malnourished men and women with sarcopenia: a multicenter, randomized, double-blinded, controlled trial","volume":"17","author":"Cramer","year":"2016","journal-title":"J Am Med Directors Assoc"},{"issue":"5","key":"2023082522372521400_lvad108-B40","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1093\/ajcn\/nqy214","article-title":"Protein supplementation improves muscle mass and physical performance in undernourished prefrail and frail elderly subjects: a randomized, double-blind, placebo-controlled trial","volume":"108","author":"Park","year":"2018","journal-title":"Am J Clin Nutr"},{"key":"2023082522372521400_lvad108-B41","first-page":"5","article-title":"KDIGO 2012 clinical practice guideline for the evaluation and management of chronic kidney disease","volume":"3","author":"Eknoyan","year":"2013","journal-title":"Kidney Int"},{"issue":"3","key":"2023082522372521400_lvad108-B42","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1111\/j.1440-1746.2011.06951.x","article-title":"Late evening snack: exploiting a period of anabolic opportunity in cirrhosis","volume":"27","author":"Tsien","year":"2012","journal-title":"J Gastroenterol Hepatol"},{"issue":"2","key":"2023082522372521400_lvad108-B43","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/ki.2014.320","article-title":"Urea for hyponatremia?","volume":"87","author":"Sterns","year":"2015","journal-title":"Kidnet Int"},{"issue":"6","key":"2023082522372521400_lvad108-B44","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1002\/acr.24180","article-title":"American College of Rheumatology guideline for the management of gout","volume":"2020","author":"FitzGerald","year":"2020","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"2023082522372521400_lvad108-B45","author":"Swiss Federal Food Safety and Veterinary Office (FSVO)"}],"container-title":["European Journal of Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ejendo\/advance-article-pdf\/doi\/10.1093\/ejendo\/lvad108\/51040696\/lvad108.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ejendo\/article-pdf\/189\/2\/252\/51261817\/lvad108.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ejendo\/article-pdf\/189\/2\/252\/51261817\/lvad108.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T22:38:02Z","timestamp":1693003082000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/189\/2\/252\/7237412"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":45,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,8,2]]}},"URL":"https:\/\/doi.org\/10.1093\/ejendo\/lvad108","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,8]]},"published":{"date-parts":[[2023,8]]}}}