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Approximately half of CHH patients also have decreased or absent sense of smell, that is, Kallmann syndrome (KS). We describe a patient with White\u2013Sutton syndrome (developmental delay and autism spectrum disorder) and KS due to a heterozygous de novo mutation in POGZ (c.2857C&amp;gt;T, p.(Gln953*)), a gene encoding pogo transposable element derived with zinc finger domain, which acts as a transcriptomic regulator of neuronal networks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design and Methods<\/jats:title><jats:p>We modeled the role of POGZ in CHH by generating 2 clonal human pluripotent stem cell lines with CRISPR\/Cas9, carrying either the heterozygous patient mutation (H11 line) or a homozygous mutation (c.2803-2906del; p.E935Kfs*7 encoding a truncated POGZ protein; F6del line).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the differentiation to GnRH neurons, neural progenitors derived from F6del line displayed severe proliferation defect, delayed wound-healing capacity, downregulation of intermediate progenitor neuron genes TBR1 and TBR2, and immature neuron markers PAX6 and TUBB3 and gave rise to fewer neurons with shorter neurites and less neurite branch points compared to the WT and H11 lines (P &amp;lt; .005). Both lines, however, could be successfully differentiated to GnRH neurons.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In conclusion, this is the first report on the overlap between White\u2013Sutton syndrome and CHH. POGZ mutations do not hinder GnRH neuron formation but may cause CHH\/KS by affecting the size and motility of the anterior neural progenitor pool and neurite outgrowth.<\/jats:p><\/jats:sec>","DOI":"10.1093\/ejendo\/lvad111","type":"journal-article","created":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T00:20:10Z","timestamp":1692922810000},"page":"271-280","source":"Crossref","is-referenced-by-count":3,"title":["Congenital hypogonadotropic hypogonadism in a patient with a de novo<i>POGZ<\/i>mutation"],"prefix":"10.1093","volume":"189","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0460-0700","authenticated-orcid":false,"given":"Nazli","family":"Eskici","sequence":"first","affiliation":[{"name":"Stem Cells and Metabolism Research Program (STEMM), Faculty of Medicine, University of Helsinki , Helsinki 00014 , Finland"},{"name":"Medicum, Faculty of Medicine, University of Helsinki , Helsinki 00014 , 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