{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T05:21:09Z","timestamp":1784092869397,"version":"3.55.0"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T00:00:00Z","timestamp":1692576000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To determine pituitary function before and after nonglucocorticoid immunosuppressive therapy (NGIT) in subjects with hypophysitis and evaluate their clinical and radiologic outcomes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>Retrospective, longitudinal study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We reviewed a large database, selected subjects with hypophysitis treated with NGIT, and collected information on the duration of therapy, and clinical, hormonal, and radiologic outcomes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Twelve subjects met the inclusion criteria. Five subjects had primary hypophysitis (PH), while seven had secondary hypophysitis (SH) due to an underlying systemic inflammatory disease. Mean age \u00b1 SD was 48.0 \u00b1 15.7 years and 40.9 \u00b1 13.0 years, for PH and SH, respectively. The majority were female (PH 60% and SH 86%). BMI \u00b1 SD at presentation was 25.2 \u00b1 2.5\u2005kg\/m2 and 26.8 \u00b1 6.7\u2005kg\/m2 for PH and SH, respectively. The most common symptom at presentation was fatigue (75%). All PH subjects (100%) and 2 (28.6%) SH subjects had polyuria\/polydipsia. There was a significant decrease in mean pituitary stalk thickness after NGIT (P = .0051) (mean duration 16.5 \u00b1 4.8 months). New hormone loss or recovery occurred rarely. Mycophenolate mofetil was the most used NGIT: adverse effects prompted discontinuation in 2 out of 7 subjects.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Subjects with hypophysitis receiving NGIT had stable or improved brain\/pituitary magnetic resonance imaging findings with a significant decrease in pituitary stalk thickness. NGITs did not improve anterior pituitary function. Our findings suggest that NGIT may be considered as an alternative therapy for patients with hypophysitis who require immunosuppression.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejendo\/lvad115","type":"journal-article","created":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T10:15:45Z","timestamp":1692612945000},"page":"309-317","source":"Crossref","is-referenced-by-count":7,"title":["A novel approach to hypophysitis: outcomes using non-glucocorticoid immunosuppressive therapy"],"prefix":"10.1093","volume":"189","author":[{"given":"Janaki D","family":"Vakharia","sequence":"first","affiliation":[{"name":"Neuroendocrine Unit, Division of Endocrinology, Massachusetts General Hospital, Harvard Medical School , Boston, MA , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maged","family":"Muhammed","sequence":"additional","affiliation":[{"name":"Neuroendocrine Unit, Division of Endocrinology, Massachusetts General Hospital, Harvard Medical 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