{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:24:42Z","timestamp":1790267082334,"version":"4.1.0"},"reference-count":65,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T00:00:00Z","timestamp":1696809600000},"content-version":"vor","delay-in-days":8,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005416","name":"Research Council of Norway","doi-asserted-by":"publisher","award":["288022"],"award-info":[{"award-number":["288022"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"The Novo Nordisk Foundation","doi-asserted-by":"publisher","award":["NNF18OC0034130"],"award-info":[{"award-number":["NNF18OC0034130"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The Internal Medicine Association of Norway"},{"name":"The Legate of Dr. Nils Henrichsen and Wife Anna Henrichsen"},{"DOI":"10.13039\/501100005036","name":"University of Bergen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005036","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Western Regional Health Authorities"},{"name":"Department of Medicine and Hormone Laboratory"},{"DOI":"10.13039\/501100010586","name":"Haukeland University Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004348","name":"Stockholm County Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004348","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004047","name":"Karolinska Institutet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,10,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Increased prevalence of cardiovascular disease has been reported in autoimmune Addison's disease (AAD), but pathomechanisms are poorly understood.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>Cross-sectional study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We compared serum levels of 177 cardiovascular and inflammatory biomarkers in 43 patients with AAD at &amp;gt;18-h glucocorticoid withdrawal and 43 matched controls, overall and stratified for sex. Biomarker levels were correlated with the frequency of adrenal crises and quality of life (QoL) by AddiQoL-30. Finally, we investigated changes in biomarker levels following 250\u2005\u00b5g tetracosactide injection in patients without residual adrenocortical function (RAF) to explore glucocorticoid-independent effects of high ACTH.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Nineteen biomarkers significantly differed between patients with AAD and controls; all but 1 (ST1A1) were higher in AAD. Eight biomarkers were significantly higher in female patients compared with controls (IL6, MCP1, GAL9, SPON2, DR4, RAGE, TNFRSF9, and PGF), but none differed between male patients and controls. Levels of RAGE correlated with the frequency of adrenal crises (r = 0.415, P = .006) and AddiQoL-30 scores (r = \u22120.347, P = .028) but not after correction for multiple testing. PDL2 and leptin significantly declined 60\u2005min after injection of ACTH in AAD without RAF (\u22120.15 normalized protein expression [NPX], P = .0001, and \u22120.25 NPX, P = .0003, respectively).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>We show that cardiovascular and inflammatory biomarkers are altered in AAD compared with controls, particularly in women. RAGE might be a marker of disease severity in AAD, associated with more adrenal crises and reduced QoL. High ACTH reduced PDL2 and leptin levels in a glucocorticoid-independent manner but the overall effect on biomarker profiles was small.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejendo\/lvad136","type":"journal-article","created":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T10:29:39Z","timestamp":1696847379000},"page":"438-447","source":"Crossref","is-referenced-by-count":8,"title":["Altered biomarkers for cardiovascular disease and inflammation in autoimmune Addison's disease \u2013 a cross-sectional study"],"prefix":"10.1093","volume":"189","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5981-6800","authenticated-orcid":false,"given":"\u00c5se Bjorvatn","family":"S\u00e6vik","sequence":"first","affiliation":[{"name":"Department of Clinical Science, University of Bergen , Bergen 5021 , Norway"},{"name":"K.G. Jebsen Center for Autoimmune Disorders, University of Bergen , Bergen 5021 , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6116-7689","authenticated-orcid":false,"given":"Grethe","family":"Ueland","sequence":"additional","affiliation":[{"name":"Department of Clinical Science, University of Bergen , Bergen 5021 , Norway"},{"name":"K.G. Jebsen Center for Autoimmune Disorders, University of Bergen , Bergen 5021 , Norway"},{"name":"Department of Medicine, Haukeland University Hospital , Bergen 5021 , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna-Karin","family":"\u00c5kerman","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Surgery, Karolinska Institutet , Stockholm 171 77 , Sweden"},{"name":"Department of Medicine, \u00d6rebro University Hospital , \u00d6rebro 702 17 , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paal","family":"Methlie","sequence":"additional","affiliation":[{"name":"Department of Clinical Science, University of Bergen , Bergen 5021 , Norway"},{"name":"K.G. Jebsen Center for Autoimmune Disorders, University of Bergen , Bergen 5021 , Norway"},{"name":"Department of Medicine, Haukeland University Hospital , Bergen 5021 , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4028-1671","authenticated-orcid":false,"given":"Marcus","family":"Quinkler","sequence":"additional","affiliation":[{"name":"Practice for Endocrinology and Nephrology, Endocrinology in Charlottenburg , Berlin 10627 , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders Palmstr\u00f8m","family":"J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Oslo University Hospital , Oslo 0372 , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"H\u00f6ybye","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Surgery, Karolinska Institutet , Stockholm 171 77 , Sweden"},{"name":"Department of Endocrinology, Karolinska University Hospital , Stockholm 171 77 , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra W J","family":"Debowska","sequence":"additional","affiliation":[{"name":"Department of Medicine, Vestfold Hospital Trust , T\u00f8nsberg 3103 , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f8rn Gunnar","family":"Nedreb\u00f8","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Haugesund Hospital , Haugesund 5528 , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Lise","family":"Dahle","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Haugesund Hospital , Haugesund 5528 , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siri","family":"Carlsen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Stavanger University Hospital , Stavanger 4019 , 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