{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T03:05:45Z","timestamp":1793070345485,"version":"4.5.0"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Centre de R\u00e9f\u00e9rence des Maladies endocriniennes Rares de la Croissance et du D\u00e9veloppement"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>While the risk for hypoglycemia during acute illness is well described in children with classical congenital adrenal hyperplasia (CAH), there is little evidence for the prevalence of asymptomatic hypoglycemia and the daily glucose patterns in CAH. Herein, we explored the daytime glucose profile of children with classical CAH.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We conducted an observational study in 11 children (6 female; age 3.1 years [1.4, 5.1]; body mass index 17.3\u2005kg\/m2 [15.6, 17.9]) with a genetic diagnosis of classical CAH receiving hydrocortisone and fludrocortisone replacement therapy. Participants underwent 2 14-day continuous glucose monitoring (CGM) sessions and an inpatient 24\u2005h series cortisol and adrenocorticotropic hormone (ACTH) measures. Data were analyzed for 3 daytime lags (7 Am-4 Pm, 4 Pm-10pm, 10 Pm-7 Am) corresponding to the hydrocortisone dosing period with cortisol and ACTH measured before the hydrocortisone dose.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Eleven participants completed at least 1 CGM session, and 7 out of 11 underwent both the CGM session and the cortisol\/ACTH serial measures. In the whole cohort, the percentage of time of sensor glucose values &amp;lt;70\u2005mg\/dL was higher during the 10 Pm-7 Am and the 7 Am-4 Pm time slots than in the late afternoon period (17% [7, 54] and 15% [6.8, 24] vs 2% [1.1, 16.7] during the periods 7 Am-4 Pm and 4 Pm-10 Pm, respectively [P = .006 and P = .003]). Nighttime hypoglycemia was mostly spent below the 65\u2005mg\/dL (10.9% [4.1, 34]). The glycemic pattern paralleled the nadir of daily cortisol at 8 Am (0.72 [0.45, 1]\u03bcg\/dL). A greater percentage of time in hypoglycemia was associated with lower cortisol concentration at 7 Am and 10 Pm (P &amp;lt; .001 and P = .005).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Continuous glucose monitoring demonstrated a disrupted daily glucose pattern in children with CAH, paralleled by a lower cortisol concentration.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Clinicaltrials.gov registration<\/jats:title>\n                  <jats:p>NCT04322435<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejendo\/lvad147","type":"journal-article","created":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T14:33:20Z","timestamp":1699540400000},"page":"K19-K24","source":"Crossref","is-referenced-by-count":3,"title":["Glucose pattern in children with classical congenital adrenal hyperplasia: evidence from continuous glucose monitoring"],"prefix":"10.1093","volume":"189","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8885-3056","authenticated-orcid":false,"given":"Alfonso","family":"Galderisi","sequence":"first","affiliation":[{"name":"Department of Paediatric Endocrinology, Diabetology, and Gynaecology, Necker\u2013Enfants Malades University Hospital, Centre de R\u00e9f\u00e9rence des Maladies endocriniennes Rares de la Croissance et du D\u00e9veloppement (fili\u00e8re FIRENDO), AP-HP Centre , Paris , France"},{"name":"Department of Pediatrics, Pediatric Endocrinology, Yale University , New Haven, CT , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3870-202X","authenticated-orcid":false,"given":"Dulanjalee","family":"Kariyawasam","sequence":"additional","affiliation":[{"name":"Department of Paediatric Endocrinology, Diabetology, and Gynaecology, Necker\u2013Enfants Malades University Hospital, Centre de R\u00e9f\u00e9rence des Maladies endocriniennes Rares de la Croissance et du D\u00e9veloppement (fili\u00e8re FIRENDO), AP-HP Centre , Paris , France"},{"name":"Faculty of Medicine, Universit\u00e9 Paris Cit\u00e9 , Paris , France"},{"name":"Cochin Institute, INSERM U1016 , Paris , France"},{"name":"IMAGINE Institute Affiliate, INSERM U1163 , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1164-5862","authenticated-orcid":false,"given":"Athanasia","family":"Stoupa","sequence":"additional","affiliation":[{"name":"Department of Paediatric Endocrinology, Diabetology, and Gynaecology, Necker\u2013Enfants Malades University Hospital, Centre de R\u00e9f\u00e9rence des Maladies endocriniennes Rares de la Croissance et du D\u00e9veloppement (fili\u00e8re FIRENDO), AP-HP Centre , Paris , France"},{"name":"Faculty of Medicine, Universit\u00e9 Paris Cit\u00e9 , Paris , France"},{"name":"Cochin Institute, INSERM U1016 , Paris , France"},{"name":"IMAGINE Institute Affiliate, INSERM U1163 , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrien Nguyen","family":"Quoc","sequence":"additional","affiliation":[{"name":"Department of Paediatric Endocrinology, Diabetology, and Gynaecology, Necker\u2013Enfants Malades University Hospital, Centre de R\u00e9f\u00e9rence des Maladies endocriniennes Rares de la Croissance et du D\u00e9veloppement (fili\u00e8re FIRENDO), AP-HP Centre , Paris , France"},{"name":"Faculty of Medicine, Universit\u00e9 Paris Cit\u00e9 , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5237-0631","authenticated-orcid":false,"given":"Graziella","family":"Pinto","sequence":"additional","affiliation":[{"name":"Department of Paediatric Endocrinology, Diabetology, and Gynaecology, Necker\u2013Enfants Malades University Hospital, Centre de R\u00e9f\u00e9rence des Maladies endocriniennes Rares de la Croissance et du D\u00e9veloppement (fili\u00e8re FIRENDO), AP-HP Centre , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magali","family":"Viaud","sequence":"additional","affiliation":[{"name":"Department of Paediatric Endocrinology, Diabetology, and Gynaecology, Necker\u2013Enfants Malades University Hospital, Centre de R\u00e9f\u00e9rence des Maladies endocriniennes Rares de la Croissance et du D\u00e9veloppement (fili\u00e8re FIRENDO), AP-HP Centre , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7590-3963","authenticated-orcid":false,"given":"Severine","family":"Brabant","sequence":"additional","affiliation":[{"name":"Department of Functional Explorations, Necker\u2013Enfants Malades University Hospital, AP-HP Centre , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3759-3490","authenticated-orcid":false,"given":"Jacques","family":"Beltrand","sequence":"additional","affiliation":[{"name":"Department of Paediatric Endocrinology, Diabetology, and Gynaecology, Necker\u2013Enfants Malades University Hospital, Centre de R\u00e9f\u00e9rence des Maladies endocriniennes Rares de la Croissance et du D\u00e9veloppement (fili\u00e8re FIRENDO), AP-HP Centre , Paris , France"},{"name":"Faculty of Medicine, Universit\u00e9 Paris Cit\u00e9 , Paris , France"},{"name":"Cochin Institute, INSERM U1016 , Paris , France"},{"name":"IMAGINE Institute Affiliate, INSERM U1163 , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2639-352X","authenticated-orcid":false,"given":"Michel","family":"Polak","sequence":"additional","affiliation":[{"name":"Department of Paediatric Endocrinology, Diabetology, and Gynaecology, Necker\u2013Enfants Malades University Hospital, Centre de R\u00e9f\u00e9rence des Maladies endocriniennes Rares de la Croissance et du D\u00e9veloppement (fili\u00e8re FIRENDO), AP-HP Centre , Paris , France"},{"name":"Faculty of Medicine, Universit\u00e9 Paris Cit\u00e9 , Paris , France"},{"name":"Cochin Institute, INSERM U1016 , Paris , France"},{"name":"IMAGINE Institute Affiliate, INSERM U1163 , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1135-933X","authenticated-orcid":false,"given":"Dinane","family":"Samara-Boustani","sequence":"additional","affiliation":[{"name":"Department of Paediatric Endocrinology, Diabetology, and Gynaecology, Necker\u2013Enfants Malades University Hospital, Centre de R\u00e9f\u00e9rence des Maladies endocriniennes Rares de la Croissance et du D\u00e9veloppement (fili\u00e8re FIRENDO), AP-HP Centre , Paris , 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