{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T21:09:45Z","timestamp":1775682585865,"version":"3.50.1"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T00:00:00Z","timestamp":1701302400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Programa Institucional de Bolsas de Inicia\u00e7\u00e3o Cient\u00edfica da"},{"DOI":"10.13039\/501100004909","name":"Universidade Federal do Rio Grande do Sul","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004909","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fundo de Incentivo \u00e0 Pesquisa e Eventos do"},{"DOI":"10.13039\/501100003810","name":"Hospital de Cl\u00ednicas de Porto Alegre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003810","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Conselho Nacional Pesquisa e Desenvolvimento"},{"DOI":"10.13039\/501100004263","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do estado do Rio Grande do Sul","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004263","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>The influence of age on the malignant cytology rate of thyroid nodules remains uncertain. The American College of Radiology Thyroid Imaging Reporting and Data System (ACR TI-RADS) is currently used to guide subsequent investigations of thyroid nodules, regardless of clinical variables. This study aimed to investigate the impact of age on the malignant cytology rates of thyroid nodules and the diagnostic performance of ACR TI-RADS across different age groups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>A retrospective, single-center, observational study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Patients aged \u2265 20 years with thyroid nodules, who underwent fine-needle aspiration biopsy between 2012 and 2019 were evaluated. Ultrasound images were used to obtain the TI-RADS data. Malignancy was determined based on suspicious for malignancy (Bethesda V) and malignant (Bethesda VI) cytology results or malignancy in cell block analysis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 1023 nodules from 921 patients (88.2% female) were analyzed. The median age was 58.5 (interquartile range [IQR], 41.1-66.6) years, and the median nodule size was 2.4 (IQR, 1.7-3.6) cm. Stratification by age revealed a decreasing prevalence of malignant cytology across subgroups of 20-39, 40-59, and \u226560 years (10.7%, 8.5%, and 3.7%, respectively; P = .002). After adjusting for sex, multinodularity, nodule size, and ACR TI-RADS category, we observed that each year of age reduced the OR for malignant cytology by 3.0% (95% CI: 0.7%-5.3%; P = .011). When comparing the subgroups of 20-39 and \u226560 years, the malignant cytology rate decreased by half in TI-RADS 4 (from 21.4% to 10.4%) and two-thirds in TI-RADS 5 (from 64.7% to 22.6%).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Our study demonstrated that as patient age increased, the rate of malignant cytology in thyroid nodules decreased. Moreover, age significantly influences the malignancy rates of thyroid nodules classified according to the ACR TI-RADS.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejendo\/lvad162","type":"journal-article","created":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T23:44:37Z","timestamp":1701301477000},"page":"584-589","source":"Crossref","is-referenced-by-count":6,"title":["Age-related variation in malignant cytology rates of thyroid nodules: insights from a retrospective observational study assessing the ACR TI-RADS"],"prefix":"10.1093","volume":"189","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7402-6102","authenticated-orcid":false,"given":"Leonardo Barbi","family":"Walter","sequence":"first","affiliation":[{"name":"Thyroid Unit, Hospital de Cl\u00ednicas de Porto Alegre, Medical School, Universidade Federal do Rio Grande do Sul , CEP 90035-903 Porto Alegre, RS , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula 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Borsatto","family":"Zanella","sequence":"additional","affiliation":[{"name":"Thyroid Unit, Hospital de Cl\u00ednicas de Porto Alegre, Medical School, Universidade Federal do Rio Grande do Sul , CEP 90035-903 Porto Alegre, RS , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo Sasso","family":"Faccin","sequence":"additional","affiliation":[{"name":"Radiology Department, Hospital de Cl\u00ednicas de Porto Alegre, Medical School, Universidade Federal do Rio Grande do Sul , CEP 90035-903 Porto Alegre, RS , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauricio","family":"Farenzena","sequence":"additional","affiliation":[{"name":"Radiology Department, Hospital de Cl\u00ednicas de Porto Alegre, Medical School, Universidade Federal do Rio Grande do Sul , CEP 90035-903 Porto Alegre, RS , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura Fernandes","family":"Xavier","sequence":"additional","affiliation":[{"name":"Department of Medicine, Medical School, Universidade do Vale do Rio dos Sinos , CEP 93022-750 S\u00e3o Leopoldo, RS , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bianca Dalla Costa","family":"Zorzi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Medical School, Universidade do Vale do Rio dos Sinos , CEP 93022-750 S\u00e3o Leopoldo, RS , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcia Silveira","family":"Graudenz","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hospital de Cl\u00ednicas de Porto Alegre, Medical School, Universidade Federal do Rio Grande do Sul , CEP 90035-903 Porto Alegre, RS , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael Selbach","family":"Scheffel","sequence":"additional","affiliation":[{"name":"Thyroid Unit, Hospital de Cl\u00ednicas de Porto Alegre, 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