{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T07:02:17Z","timestamp":1789628537949,"version":"build-2803163510"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,12,26]],"date-time":"2023-12-26T00:00:00Z","timestamp":1703548800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science","award":["18K08514"],"award-info":[{"award-number":["18K08514"]}]},{"name":"Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science","award":["21KK0149"],"award-info":[{"award-number":["21KK0149"]}]},{"name":"Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science","award":["21K08555"],"award-info":[{"award-number":["21K08555"]}]},{"name":"Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science","award":["21K20933"],"award-info":[{"award-number":["21K20933"]}]},{"name":"Harmonic Ito Foundation"},{"DOI":"10.13039\/501100006062","name":"Foundation for Promotion of Cancer Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006062","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministry of Health, Labor and Welfare"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The pathogenesis of anti-pituitary-specific transcription factor-1 (PIT-1) hypophysitis was gradually revealed as cases emerged. Our comprehensive analysis, including all reported cases, identified a new instance of anti-PIT-1 hypophysitis postimmune checkpoint inhibitor therapy. All 9 patients exhibited extremely low growth hormone (GH), prolactin (PRL), and thyroid-stimulating hormone (TSH) levels; 2 had a slightly atrophic pituitary gland; 4 had thymoma, and 5 had malignant neoplasms of diffuse large B-cell lymphoma (DLBCL) and other origins. Patients with thymoma showed multiple autoimmune diseases. HLA-A*24:02 and\/or A*02:06 were present in six and DR53 in 5 cases analyzed. High anti-PIT-1 antibody titers and ectopic PIT-1 expression in the cytosol and nucleus of the tumor tissues were observed in patients with thymoma or DLBCL, whereas it was exclusively observed in the nuclei of a bladder cancer patient. These findings provide new insights into the pathophysiology of paraneoplastic autoimmune hypophysitis.<\/jats:p>","DOI":"10.1093\/ejendo\/lvad179","type":"journal-article","created":{"date-parts":[[2023,12,26]],"date-time":"2023-12-26T11:36:34Z","timestamp":1703590594000},"page":"K1-K7","source":"Crossref","is-referenced-by-count":14,"title":["Clinical features of anti-pituitary-specific transcription factor-1 (PIT-1) hypophysitis: a new aspect of paraneoplastic autoimmune condition"],"prefix":"10.1093","volume":"190","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7996-232X","authenticated-orcid":false,"given":"Shin","family":"Urai","sequence":"first","affiliation":[{"name":"Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine , Kobe, Hyogo 650-0017 , 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