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No studies evaluated bone geometric and strain\u2013stress values in CS patients after remission thus far.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods<\/jats:title>\n                    <jats:p>Thirty-two women with CS in remission (mean age [\u00b1SD] 51 \u00b1 11; body mass index [BMI], 27 \u00b1 4 kg\/m2; mean time of remission, 120 \u00b1 90 months) and 32 age-, BMI-, and gonadal status\u2013matched female controls. Quantitative computed tomography (QCT) was used to assess volumetric bone mineral density (vBMD) and buckling ratio, cross-sectional area, and average cortical thickness at the level of the proximal femur. Finite element (FE) models were generated from QCT to calculate strain and stress values (maximum principal strain [MPE], maximum strain energy density [SED], maximum Von Mises [VM], and maximum principal stress [MPS]). Areal BMD (aBMD) and trabecular bone score (TBS) were assessed by dual-energy X-ray absorptiometry (2D DXA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Trabecular vBMD at total hip and trochanter were lower in CS as compared with controls (P &amp;lt; .05). Average cortical thickness was lower, and buckling ratio was greater in CS vs controls (P &amp;lt; .01). All strain and stress values were higher in CS patients vs controls (P &amp;lt; .05). 2D DXA\u2013derived measures were similar between patients and controls (P &amp;gt; .05). Prior hypercortisolism predicted both VM (\u03b2 .30, P = .014) and MPS (\u03b2 .30, P = .015), after adjusting for age, BMI, menopause, delay to diagnosis, and duration of remission.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Women with prior hypercortisolism have reduced trabecular vBMD and impaired bone geometrical and mechanical properties, which may contribute to an elevated fracture risk despite long-term remission.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ejendo\/lvae004","type":"journal-article","created":{"date-parts":[[2024,1,20]],"date-time":"2024-01-20T15:26:06Z","timestamp":1705764366000},"page":"86-95","source":"Crossref","is-referenced-by-count":13,"title":["Evaluation of bone-related mechanical properties in female patients with long-term remission of Cushing's syndrome using quantitative computed tomography\u2013based finite element 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Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Malouf","sequence":"additional","affiliation":[{"name":"Mineral Metabolism Unit, Hospital Sant Pau , 08025 Barcelona , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana","family":"Martel-Duguech","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Research Center for Pituitary Diseases, Hospital Sant Pau, IIB-SPau, Department of Medicine, Universitat Aut\u00f2noma de Barcelona , 08025 Barcelona , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Amodru","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Research Center for Pituitary Diseases, Hospital Sant Pau, IIB-SPau, Department of Medicine, Universitat Aut\u00f2noma de Barcelona , 08025 Barcelona , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Gil","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Research Center for Pituitary Diseases, Hospital Sant Pau, IIB-SPau, Department of Medicine, Universitat Aut\u00f2noma de Barcelona , 08025 Barcelona , Spain"},{"name":"Endocrine Research Unit, Germans Trias i Pujol Research Institute (IGTP) , 08916 Badalona , Spain"},{"name":"Centro de Investigaci\u00f3n en Red de Enfermedades Raras, CIBERER, Unit 747, Instituto de Salud Carlos III , 28029 Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaqu\u00edn A","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Centre Internacional de M\u00e8todes Num\u00e8rics en Enginyeria, CIMNE , 08034 Barcelona , Spain"},{"name":"E.S. d\u2019Enginyeries Industrial, Aeroespacial i Audiovisual de Terrassa, Technical University of Catalonia , C\/Colom, 11 , 08222 Terrassa, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel Puig","family":"Domingo","sequence":"additional","affiliation":[{"name":"Endocrine Research Unit, Germans Trias i Pujol Research Institute (IGTP) , 08916 Badalona , Spain"},{"name":"Centro de Investigaci\u00f3n en Red de Enfermedades Raras, CIBERER, Unit 747, Instituto de Salud Carlos III , 28029 Madrid , Spain"},{"name":"Universitat Aut\u00f2noma de Barcelona (UAB), 08193 Bellaterra, Spain School of Medicine,"},{"name":"Endocrinology and Nutrition Department, Germans Trias i Pujol Hospital , 08916 Badalona , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan M","family":"Webb","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Research Center for Pituitary Diseases, Hospital Sant Pau, IIB-SPau, Department of Medicine, Universitat Aut\u00f2noma de Barcelona , 08025 Barcelona , Spain"},{"name":"Centro de Investigaci\u00f3n en Red de Enfermedades Raras, 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