{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T19:43:34Z","timestamp":1790279014438,"version":"4.1.0"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,2,24]],"date-time":"2024-02-24T00:00:00Z","timestamp":1708732800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006095","name":"South-Eastern Norway Regional Health Authority","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006095","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Patients with active acromegaly present a decreased adipose tissue (AT) mass, and short-term studies show that treatment leads to AT depot-specific gain. However, it remains unclear if the increase is persistent in the long-term perspective and\/or is sex-dependent.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>To characterize the depot-specific changes of AT after treatment of acromegaly and identify contributing factors.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Adipose tissue, including visceral (VAT), subcutaneous (SAT), and total (TAT), and android to gynoid ratio (A\/G ratio) were measured by dual energy X-ray absorptiometry at diagnosis (n = 62), and after treatment at short-term (median (IQR) 1.9 (1.5-2.3)) and long-term 5.5 (3.9-9.5) years, and correlated to clinical and biochemical measurements. Growth hormone (GH), insulin-like growth factor 1 (IGF-1), glucose and HbA1c levels, gonadal status, and the presence of diabetes mellitus were recorded. Remission status was assessed at the long-term visit (IGF-1\/ULN \u2264 1.3). Differences in the temporal course of AT from baseline to short- and long-term follow-up according to sex, diabetes, gonadal, and remission status were evaluated by mixed model analysis, adjusted for age.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Despite a stable body mass index, VAT and A\/G ratio increased at both time points, whereas SAT mainly increased at short-term, plateauing afterwards (P &amp;lt; .05 for all). Visceral adipose tissue and A\/G ratio were higher in men (P = .035 and P &amp;lt; .001), and the A\/G ratio increased more than in women (P = .003). Glucose and HbA1c decreased short-term (P &amp;lt; .05) and remained stable at long-term. The increase in AT depots correlated with the decrease of disease activity at long-term. Remission status had no effect on changes in AT mass during follow-up.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Treatment of acromegaly leads to an increase in AT mass in a depot- and sex-specific manner both at short-term and long-term follow-up. Glucose metabolism improves rapidly after disease control and persists.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejendo\/lvae016","type":"journal-article","created":{"date-parts":[[2024,2,24]],"date-time":"2024-02-24T23:17:35Z","timestamp":1708816655000},"page":"K37-K42","source":"Crossref","is-referenced-by-count":7,"title":["Long-term depot specific changes in adipose tissue after treatment of acromegaly"],"prefix":"10.1093","volume":"190","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9894-5245","authenticated-orcid":false,"given":"Camilla M","family":"Falch","sequence":"first","affiliation":[{"name":"Section of Specialized Endocrinology, Department of Endocrinology, Oslo University Hospital (OUS) , PO Box 4950 - Nydalen, 0424 Oslo , Norway"},{"name":"Institute of Clinical Medicine, Faculty of Medicine, University of Oslo (UIO) , PO Box 1171 - Blindern, 0318 Oslo , Norway"},{"name":"Research Institute of Internal Medicine, OUS , PO Box 4950 - Nydalen, 0424 Oslo , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"Godang","sequence":"additional","affiliation":[{"name":"Section of Specialized Endocrinology, Department of Endocrinology, Oslo University Hospital (OUS) , PO Box 4950 - Nydalen, 0424 Oslo , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tove","family":"Lekva","sequence":"additional","affiliation":[{"name":"Research Institute of Internal Medicine, OUS , PO Box 4950 - Nydalen, 0424 Oslo , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thor","family":"Ueland","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, Faculty of Medicine, University of Oslo (UIO) , PO Box 1171 - Blindern, 0318 Oslo , Norway"},{"name":"Research Institute of Internal Medicine, OUS , PO Box 4950 - Nydalen, 0424 Oslo , Norway"},{"name":"Thrombosis Research Center (TREC), Division of Internal Medicine, University Hospital of North Norway , PO Box 6050 - Langes, 9037 Troms\u00f8 , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3443-884X","authenticated-orcid":false,"given":"Ansgar","family":"Heck","sequence":"additional","affiliation":[{"name":"Section of Specialized Endocrinology, Department of Endocrinology, Oslo University Hospital (OUS) , PO Box 4950 - Nydalen, 0424 Oslo , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0654-4610","authenticated-orcid":false,"given":"Jens","family":"Bollerslev","sequence":"additional","affiliation":[{"name":"Section of Specialized Endocrinology, Department of Endocrinology, Oslo University Hospital (OUS) , PO Box 4950 - Nydalen, 0424 Oslo , Norway"},{"name":"Institute of Clinical Medicine, Faculty of Medicine, University of Oslo (UIO) , PO Box 1171 - Blindern, 0318 Oslo , 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