{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T04:58:53Z","timestamp":1791435533763,"version":"4.3.3"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T00:00:00Z","timestamp":1710374400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100018956","name":"NIHR Cambridge Biomedical Research Centre","doi-asserted-by":"publisher","award":["BRC-1215-20014"],"award-info":[{"award-number":["BRC-1215-20014"]}],"id":[{"id":"10.13039\/501100018956","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018956","name":"NIHR Cambridge Biomedical Research Centre","doi-asserted-by":"publisher","award":["NIHR203312"],"award-info":[{"award-number":["NIHR203312"]}],"id":[{"id":"10.13039\/501100018956","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>L-[methyl-11C]-methionine-positron emission tomography (Met-PET) is a potentially important imaging adjunct in the diagnostic workup of pituitary adenomas, including somatotroph tumors. Met-PET can identify residual or occult disease and make definitive therapies accessible to a subgroup of patients who would otherwise require lifelong medical therapy. However, existing data on its use are still limited to small case series. Here, we report the largest single-center experience (n = 61) in acromegaly.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A total of 189 cases of acromegaly were referred to our national Met-PET service in the last 12 years. For this analysis, we have reviewed outcomes in those 61 patients managed exclusively by our multidisciplinary team (single center, single surgeon). Referral indications were as follows: indeterminate magnetic resonance imaging (MRI; n = 38, 62.3%), occult residual (n = 14, 23.0%), (radio-)surgical planning (n = 6, 9.8%), and occult de novo tumor (n = 3, 4.9%).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 33\/61 patients (54.1%) underwent PET-guided surgery. Twenty-four of 33 patients (72.7%) achieved complete biochemical remission following (re-)surgery. Insulin-like growth factor 1 levels were reduced to &amp;lt;2 \u00d7 upper limit of normal (ULN) in 6 of the remaining 9 cases, 3 of whom achieved levels of &amp;lt;1.1 \u00d7 ULN compared with mean preoperative levels of 2.4 \u00d7 ULN (SD 0.8) for n = 9. Only 3 patients developed single new hormonal deficits (gonadotropic\/thyrotropic insufficiency). There were no neurovascular complications after surgery.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>In patients with persistent\/recurrent acromegaly or occult tumors, Met-PET can facilitate further targeted intervention (surgery\/radiosurgery). This led to complete remission in most cases (24\/33) or significant improvement with comparatively low risk of complications. L-[methyl-11C]-methionine-positron emission tomography should therefore be considered in all patients who are potential candidates for further surgical intervention but present no clear target on MRI.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejendo\/lvae028","type":"journal-article","created":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T23:04:13Z","timestamp":1710371053000},"page":"307-313","source":"Crossref","is-referenced-by-count":14,"title":["Real-world experience with 11C-methionine positron emission tomography in the management of acromegaly"],"prefix":"10.1093","volume":"190","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4464-0427","authenticated-orcid":false,"given":"Linus","family":"Haberbosch","sequence":"first","affiliation":[{"name":"Cambridge Endocrine Molecular Imaging Group, Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge , Cambridge CB2 0QQ , United Kingdom"},{"name":"National Institute for Health Research Cambridge Biomedical Research Centre, Addenbrooke\u2019s Hospital , Cambridge CB2 0QQ , United Kingdom"},{"name":"Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, Department of Endocrinology and Metabolism, European Reference Network on Rare Endocrine Conditions (Endo-ERN) , Berlin 10117 , Germany"},{"name":"Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, BIH Biomedical Innovation Academy, BIH Charit\u00e9 Junior Digital Clinician Scientist Program, Berlin Institute of Health , Berlin 10117 , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"MacFarlane","sequence":"additional","affiliation":[{"name":"Cambridge Endocrine Molecular Imaging Group, Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge , Cambridge CB2 0QQ , United Kingdom"},{"name":"National Institute for Health Research Cambridge Biomedical Research Centre, Addenbrooke\u2019s Hospital , Cambridge CB2 0QQ , United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olympia","family":"Koulouri","sequence":"additional","affiliation":[{"name":"Cambridge Endocrine Molecular Imaging Group, Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge , Cambridge CB2 0QQ , United Kingdom"},{"name":"National Institute for Health Research Cambridge Biomedical Research Centre, Addenbrooke\u2019s Hospital , Cambridge CB2 0QQ , United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Gillett","sequence":"additional","affiliation":[{"name":"Cambridge Endocrine Molecular Imaging Group, Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge , Cambridge CB2 0QQ , United Kingdom"},{"name":"National Institute for Health Research Cambridge Biomedical Research Centre, Addenbrooke\u2019s Hospital , Cambridge CB2 0QQ , United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew S","family":"Powlson","sequence":"additional","affiliation":[{"name":"Cambridge Endocrine Molecular Imaging Group, Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge , Cambridge CB2 0QQ , United Kingdom"},{"name":"National Institute for Health Research Cambridge Biomedical Research Centre, Addenbrooke\u2019s Hospital , Cambridge CB2 0QQ , United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sue","family":"Oddy","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Addenbrooke's Hospital, Cambridge Biomedical Campus , Cambridge CB2 0QQ , United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J","family":"Halsall","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Addenbrooke's Hospital, Cambridge Biomedical Campus , Cambridge CB2 0QQ , United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin A","family":"Huynh","sequence":"additional","affiliation":[{"name":"Cambridge Endocrine Molecular Imaging Group, Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge , Cambridge CB2 0QQ , United Kingdom"},{"name":"National Institute for Health Research Cambridge Biomedical Research Centre, Addenbrooke\u2019s Hospital , Cambridge CB2 0QQ , United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Radiology, Addenbrooke's Hospital, Cambridge Biomedical Campus , Cambridge CB2 0QQ , United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heok K","family":"Cheow","sequence":"additional","affiliation":[{"name":"Department of Radiology, Addenbrooke's Hospital, Cambridge Biomedical Campus , Cambridge CB2 0QQ , United Kingdom"},{"name":"Department of Nuclear Medicine, Addenbrooke's Hospital, Cambridge Biomedical Campus , Cambridge CB2 0QQ , United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Spranger","sequence":"additional","affiliation":[{"name":"Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, Department of Endocrinology and Metabolism, European Reference Network on Rare Endocrine Conditions (Endo-ERN) , Berlin 10117 , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0126-3155","authenticated-orcid":false,"given":"Knut","family":"Mai","sequence":"additional","affiliation":[{"name":"Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, Department of Endocrinology and Metabolism, European Reference Network on Rare Endocrine Conditions (Endo-ERN) , Berlin 10117 , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian J","family":"Strasburger","sequence":"additional","affiliation":[{"name":"Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, Department of Endocrinology and Metabolism, European Reference Network on Rare Endocrine Conditions (Endo-ERN) , Berlin 10117 , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J","family":"Mannion","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Addenbrooke's Hospital, Cambridge Biomedical Campus , Cambridge CB2 0QQ , United 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