{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:21:57Z","timestamp":1790695317518,"version":"4.1.0"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T00:00:00Z","timestamp":1714003200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Adamantinomatous craniopharyngioma mainly affects children. Excessive weight gain is a major long-term complication. The primary objective of this study was to assess long-term weight changes in children treated for craniopharyngioma. The secondary objectives were to identify risk factors for excessive weight gain and to look for associations with hypothalamic damage by the tumour or treatment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>Single-centre retrospective cohort study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Method<\/jats:title>\n                  <jats:p>Children managed for craniopharyngioma at our centre between 1990 and 2019 were included. The body mass index (BMI) standard deviation scores (SDS) at baseline and at last follow-up were compared. Univariate and multivariate analyses were performed in order to identify variables associated with the long-term BMI-SDS variation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The 108 patients had a mean follow-up of 10.4 years. The mean BMI-SDS increase over time was 2.11 (P &amp;lt; .001) overall, 1.21 (P &amp;lt; .001) in the group without hypothalamic involvement by the tumour, and 1.95 (P &amp;lt; .001) in the group managed using intended hypothalamus-sparing surgery. The absence of hypothalamic involvement by the tumour or treatment was significantly associated with less weight gain (P = .046 and P &amp;lt; .01, respectively). After adjustment, factors associated with a BMI-SDS change greater than 2 were female sex (P = .023), tumour involving the hypothalamus (P = .04), and higher baseline BMI (P &amp;lt; .001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Clinically significant weight gain occurred in nearly all children treated for craniopharyngioma, including those whose hypothalamus was spared by the tumour and intentionally by treatment. However, hypothalamus integrity was associated with less weight gain. Despite hypothalamus-sparing strategies, hypothalamic obesity remains a major concern, indicating a need for novel treatment approaches.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejendo\/lvae044","type":"journal-article","created":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T17:33:38Z","timestamp":1714066418000},"page":"363-373","source":"Crossref","is-referenced-by-count":18,"title":["Long-term weight gain in children with craniopharyngioma"],"prefix":"10.1093","volume":"190","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-1595-0007","authenticated-orcid":false,"given":"Sibylle","family":"Rovani","sequence":"first","affiliation":[{"name":"Paediatric Endocrinology, Diabetology, Gynaecology Department, Necker-Enfants Malades University Hospital, AP-HP Centre , Paris 75015 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Butler","sequence":"additional","affiliation":[{"name":"Department of Neonatal Medicine of Port Royal, Cochin Hospital, FHU PREMA, AP-HP Centre\u2014Universit\u00e9 Paris Cit\u00e9 , Paris 75014 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1135-933X","authenticated-orcid":false,"given":"Dinane","family":"Samara-Boustani","sequence":"additional","affiliation":[{"name":"Paediatric Endocrinology, Diabetology, Gynaecology Department, Necker-Enfants Malades University Hospital, AP-HP Centre , Paris 75015 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5237-0631","authenticated-orcid":false,"given":"Graziella","family":"Pinto","sequence":"additional","affiliation":[{"name":"Paediatric Endocrinology, Diabetology, Gynaecology Department, Necker-Enfants Malades University Hospital, AP-HP Centre , Paris 75015 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Gonzalez-Briceno","sequence":"additional","affiliation":[{"name":"Paediatric Endocrinology, Diabetology, Gynaecology Department, Necker-Enfants Malades University Hospital, AP-HP Centre , Paris 75015 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrien","family":"Nguyen Quoc","sequence":"additional","affiliation":[{"name":"Paediatric Endocrinology, Diabetology, Gynaecology Department, Necker-Enfants Malades University Hospital, AP-HP Centre , Paris 75015 ,","place":["France"]},{"name":"Faculty of Medicine, Universit\u00e9 Paris Cit\u00e9 , Paris 75006 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ga\u00eblle","family":"Vermillac","sequence":"additional","affiliation":[{"name":"Paediatric Endocrinology, Diabetology, Gynaecology Department, Necker-Enfants Malades University Hospital, AP-HP Centre , Paris 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,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9286-4831","authenticated-orcid":false,"given":"Fran\u00e7ois","family":"Doz","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Universit\u00e9 Paris Cit\u00e9 , Paris 75006 ,","place":["France"]},{"name":"Radiation Department, Proton Center , Orsay 94800 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4773-3001","authenticated-orcid":false,"given":"Jacques","family":"Grill","sequence":"additional","affiliation":[{"name":"Child and Adolescent Cancer Department, Gustave Roussy Institute , Villejuif 94800 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5993-8077","authenticated-orcid":false,"given":"Christelle","family":"Dufour","sequence":"additional","affiliation":[{"name":"Child and Adolescent Cancer Department, 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