{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:17:51Z","timestamp":1792793871924,"version":"4.5.0"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T00:00:00Z","timestamp":1716249600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Sociedad Espa\u00f1ola de Endocrinolog\u00eda y Nutrici\u00f3n","id":[{"id":"https:\/\/ror.org\/01tk4y529","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim of this study is to compare the response to first-line medical treatment in treatment-naive acromegaly patients with pure growth hormone (GH)-secreting pituitary adenoma (GH-PA) and those with GH and prolactin cosecreting PA (GH&amp;PRL-PA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>This is a retrospective multicentric study of acromegaly patients followed from 2003 to 2023 in 33 tertiary Spanish hospitals with at least 6 months of first-line medical treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Baseline characteristics, first-line medical treatment strategies, and outcomes were analyzed. We employed a multiple logistic regression full model to estimate the impact of some baseline characteristics on disease control after each treatment modality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 144 patients included, 72.9% had a GH-PA, and 27.1% had a GH&amp;PRL-PA. Patients with GH&amp;PRL-PA were younger (43.9 \u00b1 15.0 vs 51.9 \u00b1 12.7 years, P &amp;lt; .01) and harboring more frequently macroadenomas (89.7% vs 72.1%, P = .03). First-generation somatostatin receptor ligand (fgSRL) as monotherapy was given to 106 (73.6%) and a combination treatment with fgSRL and cabergoline in the remaining 38 (26.4%). Patients with GH&amp;PRL-PA received more frequently a combination therapy (56.4% vs 15.2%, P &amp;lt; .01). After 6 months of treatment, in the group of patients under fgSRL as monotherapy, those patients with GH&amp;PRL-PA had worse control compared to GH-PAs (29.4% vs 55.1%, P = .04). However, these differences in the rate of disease control between both groups disappeared when both received combination treatment with fgSRL and cabergoline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In GH&amp;PRL-PA, the biochemical control achieved with fgSRL as monotherapy is substantially worse than in patients harboring GH-PA, supporting the inclusion of cabergoline as first-line medical treatment in combination with fgSRLs in these subgroups of patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ejendo\/lvae053","type":"journal-article","created":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T12:35:59Z","timestamp":1716294959000},"page":"458-466","source":"Crossref","is-referenced-by-count":17,"title":["Effectiveness of combined first-line medical treatment in acromegaly with prolactin cosecretion"],"prefix":"10.1093","volume":"190","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8837-4343","authenticated-orcid":false,"given":"Betina","family":"Biagetti","sequence":"first","affiliation":[{"name":"Endocrinology & Nutrition Department, Hospital Universitario Vall de Hebr\u00f3n, CIBERER U747 (ISCIII), ENDO-ERN , Barcelona, PC 08032 , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0519-0072","authenticated-orcid":false,"given":"Marta","family":"Araujo-Castro","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Nutrition, Hospital Universitario Ram\u00f3n y Cajal, Instituto de Investigaci\u00f3n Biom\u00e9dica Ram\u00f3n y Cajal (IRYCIS) , Madrid, PC 28034 , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edelmiro Men\u00e9ndez","family":"Torre","sequence":"additional","affiliation":[{"name":"Endocrinology & Nutrition Department, Hospital Universitario Central de Asturias & Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA) , Asturias, PC 33011 , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ir\u00eda","family":"Novoa-Testa","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Nutrition, Hospital Universitario de A Coru\u00f1a , PC 15706, A Coru\u00f1a , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Cordido","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Nutrition, Hospital Universitario de A Coru\u00f1a , PC 15706, A Coru\u00f1a , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2378-2335","authenticated-orcid":false,"given":"Eider Pascual","family":"Corrales","sequence":"additional","affiliation":[{"name":"Endocrinology & Nutrition Department, Hospital Universitario Vall de Hebr\u00f3n, CIBERER U747 (ISCIII), ENDO-ERN , Barcelona, PC 08032 , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00edctor Rodr\u00edguez","family":"Berrocal","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Hospital Universitario Ram\u00f3n y Cajal , Madrid, PC 28034 , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Guerrero-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Endocrinology & Nutrition Department, Hospital Universitario de Bellvitge, Catalu\u00f1a L'Hospitalet de Llobregat , Barcelona, PC 08907 , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Almudena","family":"Vicente","sequence":"additional","affiliation":[{"name":"Endocrinology & Nutrition Department, Hospital Universitario de Toledo , PC 45007, Toledo , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos","family":"Percovich","sequence":"additional","affiliation":[{"name":"Endocrinology & Nutrition Department, Hospital Universitario Gregorio Mara\u00f1\u00f3n , PC 28007, Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rogelio Garc\u00eda","family":"Centeno","sequence":"additional","affiliation":[{"name":"Endocrinology & Nutrition Department, Hospital Universitario Gregorio Mara\u00f1\u00f3n , PC 28007, Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Endocrinology & Nutrition Department, Hospital Universitario Gregorio Mara\u00f1\u00f3n , PC 28007, Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Dolores Ollero","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Endocrinology & Nutrition Department, Hospital Universitario Navarra , PC 31008, Pamplona , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Irigaray","family":"Echarri","sequence":"additional","affiliation":[{"name":"Endocrinology & Nutrition Department, Hospital Universitario Navarra , PC 31008, Pamplona , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Dolores Moure","family":"Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Endocrinology & Nutrition Department, Hospital Universitario de Cruces , PC 48903, Bilbao , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Novo-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Endocrinology & Nutrition Department, Hospital Universitario Virgen de las Nieves , Granada, PC 18016 , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Calatayud","sequence":"additional","affiliation":[{"name":"Endocrinology & Nutrition Department, Hospital Universitario Doce de Octubre , Madrid, PC 28041 , 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Gonz\u00e1lez","family":"Molero","sequence":"additional","affiliation":[{"name":"Endocrinology & Nutrition Department, Hospital Regional Universitario de M\u00e1laga Ibima, plataforma BIONAND , PC 29010, M\u00e1laga , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Iglesias","sequence":"additional","affiliation":[{"name":"Endocrinology & Nutrition Department, Hospital Universitario Puerta de Hierro , Majadahonda, PC 28220, Majadahonda, Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Concepci\u00f3n","family":"Blanco","sequence":"additional","affiliation":[{"name":"Endocrinology & Nutrition Department, Hospital Universitario Pr\u00edncipe de Asturias , PC 28805, Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando Vidal-Ostos","family":"De Lara","sequence":"additional","affiliation":[{"name":"Endocrinology & Nutrition Department, Hospital Universitario Pr\u00edncipe de Asturias , PC 28805, Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paz","family":"de Miguel","sequence":"additional","affiliation":[{"name":"Endocrinology & Nutrition Department, Hospital Cl\u00ednico San Carlos , PC 28040, Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena L\u00f3pez","family":"Mezquita","sequence":"additional","affiliation":[{"name":"Endocrinology & Nutrition Department, Hospital Universitario Cl\u00ednico San Cecilio , PC 18016, Granada , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2399-4023","authenticated-orcid":false,"given":"Felicia","family":"Hanzu","sequence":"additional","affiliation":[{"name":"Endocrinology & Nutrition Department, Hospital Clinic de Barcelona , PC 08036, Barcelona , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iban","family":"Aldecoa","sequence":"additional","affiliation":[{"name":"Pathology Department, Biomedical Diagnostic Center, Hospital Clinic\u2014University of Barcelona, Neurological Tissue Bank of the Biobank, FCRB-IDIBAPS-Hospital Clinic Barcelona , PC 08026, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Aznar","sequence":"additional","affiliation":[{"name":"Endocrinology & Nutrition Department, Hospital Universitario De Albacete , PC 02006, Albacete , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4622-9508","authenticated-orcid":false,"given":"Cristina","family":"Lamas","sequence":"additional","affiliation":[{"name":"Endocrinology & Nutrition Department, Hospital Universitario De Albacete , PC 02006, Albacete , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Aulinas","sequence":"additional","affiliation":[{"name":"Endocrinology & Nutrition Department, Hospital de la Santa Creu i Sant Pau, IR-SANT PAU, CIBERER U747 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Recio","family":"C\u00f3rdova","sequence":"additional","affiliation":[{"name":"Endocrinology & Nutrition Department, Hospital Universitario de Salamanca , PC 37007, Salamanca , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariola","family":"Aviles","sequence":"additional","affiliation":[{"name":"Endocrinology & Nutrition Department, Hospital Universitario Cl\u00ednico San Cecilio , PC 18016, Granada , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Asensio-Wandosel","sequence":"additional","affiliation":[{"name":"Endocrinology & Nutrition Department, Hospital Universitario Germans Trias i Pujol , Badalona PC 08916, Catalonia , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Sampedro","sequence":"additional","affiliation":[{"name":"Endocrinology & Nutrition Department, Hospital Universitario La Princesa. Salamanca, PC 28006, Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"C\u00e1mara","sequence":"additional","affiliation":[{"name":"Endocrinology & Nutrition Department, Hospital Universitario y Polit\u00e9cnico La Fe , PC 46026, Valencia , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Paja","sequence":"additional","affiliation":[{"name":"Endocrinology & Nutrition Department, OSI Bilbao-Basurto, Hospital Universitario de Basurto, University of the Basque Country UPV\/EHU , CP 48013, Bilbao , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Ruz-Caracuel","sequence":"additional","affiliation":[{"name":"Pathology Department, Hospital Universitario Ram\u00f3n y Cajal, IRYCIS, CIBER C\u00e1ncer (CIBERONC) , PC 28034, Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Fajardo-Monta\u00f1ana","sequence":"additional","affiliation":[{"name":"Endocrinology & Nutrition Department, Hospital Universitario La Ribera , PC 46600, Valencia , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esteban Cordero","family":"Asanza","sequence":"additional","affiliation":[{"name":"Neurosurgery Department, Vall d'Hebron University Hospital , PC 08032, Barcelona , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Martinez-Saez","sequence":"additional","affiliation":[{"name":"Pathology Department, Vall d'Hebron University Hospital , PC 08032, Barcelona , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f3nica","family":"Marazuela","sequence":"additional","affiliation":[{"name":"Endocrinology & Nutrition Department, Hospital Universitario La Princesa. Salamanca, PC 28006, Madrid , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manel","family":"Puig-Domingo","sequence":"additional","affiliation":[{"name":"Endocrinology & Nutrition Department, Hospital Universitario Germans Trias i Pujol , Badalona PC 08916, Catalonia , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,5,21]]},"reference":[{"issue":"1","key":"2024062815223425800_lvae053-B1","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/s41572-019-0071-6","article-title":"Acromegaly","volume":"5","author":"Colao","year":"2019","journal-title":"Nat Rev Dis Primers"},{"issue":"6","key":"2024062815223425800_lvae053-B2","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1530\/EJE-20-0019","article-title":"Prolonged diagnostic delay in acromegaly is associated with increased morbidity and mortality","volume":"182","author":"Esposito","year":"2020","journal-title":"Eur J Endocrinol."},{"issue":"1","key":"2024062815223425800_lvae053-B3","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s11102-022-01285-1","article-title":"A systematic literature review to evaluate extended dosing intervals in the pharmacological management of acromegaly","volume":"26","author":"Fleseriu","year":"2023","journal-title":"Pituitary"},{"issue":"2","key":"2024062815223425800_lvae053-B4","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1007\/s11102-021-01193-w","article-title":"Evaluation of acromegaly treatment direct costs with respect to biochemical control and follow-up length","volume":"25","author":"Cocchiara","year":"2022","journal-title":"Pituitary"},{"issue":"1","key":"2024062815223425800_lvae053-B5","doi-asserted-by":"crossref","first-page":"R13","DOI":"10.1530\/EJE-17-0041","article-title":"Management of endocrine disease: quality of life tools for the management of pituitary disease","volume":"177","author":"Webb","year":"2017","journal-title":"Eur J Endocrinol."},{"issue":"4","key":"2024062815223425800_lvae053-B6","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.ecl.2022.04.004","article-title":"Evaluating the impact of acromegaly on quality of life","volume":"51","author":"Coopmans","year":"2022","journal-title":"Endocrinol Metab Clin North Am."},{"issue":"3","key":"2024062815223425800_lvae053-B7","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s11102-015-0700-3","article-title":"The role of cumulative growth hormone exposure in determining mortality and morbidity in acromegaly: a single centre study","volume":"19","author":"Varadhan","year":"2016","journal-title":"Pituitary"},{"issue":"1","key":"2024062815223425800_lvae053-B8","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1530\/EJE-18-0255","article-title":"Mortality in acromegaly decreased in the last decade: a systematic review and meta-analysis","volume":"179","author":"Bolfi","year":"2018","journal-title":"Eur J Endocrinol."},{"issue":"11","key":"2024062815223425800_lvae053-B9","doi-asserted-by":"crossref","first-page":"E1962","DOI":"10.3390\/jcm8111962","article-title":"The clinicopathological spectrum of acromegaly","volume":"8","author":"Akirov","year":"2019","journal-title":"J Clin Med."},{"key":"2024062815223425800_lvae053-B10","doi-asserted-by":"crossref","first-page":"dgae126","DOI":"10.1210\/clinem\/dgae126","article-title":"Differences between GH and PRL co-secreting and GH-secreting pituitary adenomas. 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acromegaly","volume":"12","author":"Puig-Domingo","year":"2021","journal-title":"Front Endocrinol (Lausanne)."},{"issue":"3","key":"2024062815223425800_lvae053-B17","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.eprac.2021.12.017","article-title":"Personalized medical treatment of patients with acromegaly: a review","volume":"28","author":"Lim","year":"2022","journal-title":"Endocr Pract"},{"key":"2024062815223425800_lvae053-B18","doi-asserted-by":"crossref","first-page":"807054","DOI":"10.3389\/fendo.2021.807054","article-title":"Hyperprolactinemia and hypopituitarism in acromegaly and effect of pituitary surgery: long-term follow-up on 529 patients","volume":"12","author":"Guo","year":"2022","journal-title":"Front Endocrinol (Lausanne)."},{"issue":"5","key":"2024062815223425800_lvae053-B19","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1530\/EJE-11-1119","article-title":"The characteristics of acromegalic patients with hyperprolactinemia and the 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