{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T12:43:48Z","timestamp":1740141828346,"version":"3.37.3"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"French Ministry of Health through Assistance Publique"},{"name":"H\u00f4pitaux de Marseille"},{"name":"National Research Agency","award":["ANR-11-INBS-0002"],"award-info":[{"award-number":["ANR-11-INBS-0002"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Pituitary stalk interruption syndrome (PSIS) is a rare cause of congenital hypopituitarism. Limited data exist on the gonadotropic status and fertility of adult women with PSIS. Our study aims to describe pubertal development and the evolution of gonadotropic function and fertility in adult women with PSIS.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>A retrospective multicentric French study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We described gonadotropic function in 56 adult women with PSIS from puberty onward. We compared live birth rates per woman with PSIS with age-matched controls from the large French epidemiological cohort (CONSTANCES). Additionally, we assessed height, body mass index (BMI), blood pressure, other metabolic parameters, and socioeconomic status.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results and Conclusions<\/jats:title>\n                  <jats:p>Among 56 women with PSIS, 36 did not experience spontaneous puberty. Of these, 13 underwent ovarian stimulation, resulting in 7 women having a total of 11 children. In the subgroup with spontaneous puberty (n = 20), 4 had a total of 8 pregnancies, while 6 developed secondary gonadotropic deficiency. Women with PSIS had fewer children than controls (0.33 vs 0.63, P = .04). Median height was also lower (160.5 vs 165.0\u2005cm, P &amp;lt; .0001). Although mean blood pressure was lower in women with PSIS compared with controls (111.3\/65.9 \u00b1 11.2\/8.1 vs 118.7\/72.1 \u00b1 10.1\/7.7\u2005mmHg, P &amp;lt; .001), there were no significant differences in other metabolic parameters, notably BMI and lipid profile. Employment\/academic status was not different in the 2 groups, but fewer women with PSIS were in relationships (42% vs 57.6% in controls, P = .02). The fertility prognosis in patients with PSIS needs optimization. Patients should be informed about the likelihood of declining gonadotropic function over time.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejendo\/lvae064","type":"journal-article","created":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T17:53:39Z","timestamp":1718042019000},"page":"501-508","source":"Crossref","is-referenced-by-count":0,"title":["Gonadotropic status in adult women with pituitary stalk interruption syndrome"],"prefix":"10.1093","volume":"190","author":[{"given":"Agla\u00e9","family":"Terray","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Diabetology and Nutrition, Ambroise Par\u00e9 University Hospital, Assistance Publique-H\u00f4pitaux de Paris , F-92100 Boulogne Billancourt , France"},{"name":"EA4340, Universit\u00e9 de Versailles Saint-Quentin-en-Yvelines, UFR des Sciences de la Sant\u00e9 Simone Veil , F-78423 Montigny-le-Bretonneux , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0735-8278","authenticated-orcid":false,"given":"Bertrand","family":"Baussart","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Assistance Publique-H\u00f4pitaux de Paris, La Piti\u00e9-Salp\u00eatri\u00e8re University Hospital , F-75013 Paris , France"},{"name":"Universit\u00e9 Paris Cit\u00e9, CNRS, INSERM, Institut Cochin , F-75014 Paris , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4540-4282","authenticated-orcid":false,"given":"Marie","family":"Zins","sequence":"additional","affiliation":[{"name":"UMS 011, Population-based Cohorts Unit, Universit\u00e9 Paris Cit\u00e9, Paris Saclay University, Universit\u00e9 de Versailles Saint-Quentin-en-Yvelines, INSERM , F-94800 Villejuif , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6161-5880","authenticated-orcid":false,"given":"Marcel","family":"Goldberg","sequence":"additional","affiliation":[{"name":"UMS 011, Population-based Cohorts Unit, Universit\u00e9 Paris Cit\u00e9, Paris Saclay University, Universit\u00e9 de Versailles Saint-Quentin-en-Yvelines, INSERM , F-94800 Villejuif , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6041-9602","authenticated-orcid":false,"given":"Sofiane","family":"Kab","sequence":"additional","affiliation":[{"name":"UMS 011, Population-based Cohorts Unit, Universit\u00e9 Paris Cit\u00e9, Paris Saclay University, Universit\u00e9 de Versailles Saint-Quentin-en-Yvelines, INSERM , F-94800 Villejuif , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laure","family":"Cazabat","sequence":"additional","affiliation":[{"name":"UMR 1198 BREED, \u00e9quipe RHuMA, UFR Simone Veil Sant\u00e9, Universit\u00e9 Versailles Saint Quentin en Yvelines , F-78423 Montigny-le-Bretonneux , France"},{"name":"Service de Neurochirurgie, H\u00f4pital Foch , F-92150 Suresnes , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathilde","family":"Bri\u00e8re","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetology and Nutrition, Ambroise Par\u00e9 University Hospital, Assistance Publique-H\u00f4pitaux de Paris , F-92100 Boulogne Billancourt , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8482-6691","authenticated-orcid":false,"given":"Thierry","family":"Brue","sequence":"additional","affiliation":[{"name":"Aix Marseille Universit\u00e9, APHM, INSERM, MMG, MarMaRa , F-13305 Marseille , France"},{"name":"Department of Endocrinology, Reference Center for Rare Pituitary Diseases HYPO, La Conception University Hospital, AP-HM , F-13305 Marseille , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Barraud","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Diabetes Nutrition, University of Reims Champagne-Ardenne, Reims University Hospital, CRESTIC , F-51092 Reims , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yves","family":"Reznik","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, C\u00f4te de Nacre University Hospital , F 14033 Caen , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6057-6840","authenticated-orcid":false,"given":"Sophie","family":"Christin-Maitre","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Saint-Antoine Hospital, Centre de R\u00e9f\u00e9rence des Maladies Endocriniennes Rares de la Croissance, Assistance Publique-H\u00f4pitaux de Paris, ER9 University Pierre et Marie Curie , F-75005 Paris , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Illouz","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Reference Center for Rare Pituitary Diseases HYPO, Angers University Hospital , F-49000 Angers , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9517-338X","authenticated-orcid":false,"given":"G\u00e9rald","family":"Raverot","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, \u201cGroupement Hospitalier Est\u201d Hospices Civils de Lyon, Reference Center for Rare Pituitary Diseases HYPO , F-69500 Bron , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacques","family":"Young","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Bic\u00eatre Hospital, Assistance Publique-H\u00f4pitaux de Paris, Reference Center for Rare Pituitary Diseases HYPO , F-94270 Le Kremlin-Bic\u00eatre , France"},{"name":"Universit\u00e9 Paris-Saclay, Inserm, Physiologie et Physiopathologie Endocriniennes , F-94270 Le Kremlin-Bic\u00eatre , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-Laure","family":"Raffin-Sanson","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetology and Nutrition, Ambroise Par\u00e9 University Hospital, Assistance Publique-H\u00f4pitaux de Paris , F-92100 Boulogne Billancourt , France"},{"name":"EA4340, Universit\u00e9 de Versailles Saint-Quentin-en-Yvelines, UFR des Sciences de la Sant\u00e9 Simone Veil , F-78423 Montigny-le-Bretonneux , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7458-7102","authenticated-orcid":false,"given":"Mirella","family":"Hage","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetology and Nutrition, Ambroise Par\u00e9 University Hospital, Assistance Publique-H\u00f4pitaux de Paris , F-92100 Boulogne Billancourt , France"},{"name":"EA4340, Universit\u00e9 de Versailles Saint-Quentin-en-Yvelines, UFR des Sciences de la Sant\u00e9 Simone Veil , F-78423 Montigny-le-Bretonneux , France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,6,10]]},"reference":[{"issue":"1","key":"2024062610005767200_lvae064-B1","doi-asserted-by":"crossref","first-page":"e53189","DOI":"10.1371\/journal.pone.0053189","article-title":"Pituitary stalk interruption syndrome in 53 postpubertal patients: factors influencing the heterogeneity of its presentation","volume":"8","author":"Pham","year":"2013","journal-title":"PLoS One"},{"issue":"4","key":"2024062610005767200_lvae064-B2","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1530\/EJE-10-0892","article-title":"Pituitary stalk interruption syndrome in 83 patients: novel HESX1 mutation and severe hormonal prognosis in malformative 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