{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T19:45:09Z","timestamp":1790279109304,"version":"4.1.0"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>X-linked hypophosphatemia (XLH) is characterized by increased concentrations of circulating fibroblast growth factor 23 (FGF-23) resulting in phosphate wasting, hypophosphatemia, atypical growth plate and bone matrix mineralization. Epidemiologic studies suggest a relationship between FGF-23, obesity, and metabolic dysfunction. The prevalence of overweight and obesity is high in children with XLH. We aimed to evaluate the prevalence of obesity and metabolic complications in adults with XLH.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We conducted a prospective cohort study in adult XLH patients from a single tertiary referral center. The proportion of patients with a BMI &amp;gt;25 kg\/m2 was the main outcome measure. Body fat mass percentage (FM%) and adipose tissue surfaces were secondary outcome measures. Glucose homeostasis (plasma glucose and insulin concentrations after fasting and 2 hours after an oral glucose tolerance test) was explored in a subgroup of patients and compared with age-, sex-, and BMI-matched healthy controls.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Among 113 evaluated patients, 85 (75%) were female and 110 (97%) carried a PHEX mutation. Sixty-three (56%) patients were overweight or obese, with a median BMI of 25.3 [IQR, 22.7; 29.2] kg\/m2. BMI was correlated with FM%, abdominal and thigh subcutaneous and intra-abdominal adipose tissue surfaces. The prevalence of impaired fasting glucose, impaired glucose tolerance, and diabetes was not different between XLH patients and matched controls.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The prevalence of overweight and obesity is high among XLH patients and is associated with excess fat mass. However, the prevalence of glucose homeostasis abnormalities is not increased in patients compared to healthy controls, suggesting that metabolically healthy overweight or obesity predominates.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejendo\/lvae089","type":"journal-article","created":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T08:09:19Z","timestamp":1723104559000},"page":"156-165","source":"Crossref","is-referenced-by-count":7,"title":["Metabolically healthy obesity in adults with X-linked hypophosphatemia"],"prefix":"10.1093","volume":"191","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8630-961X","authenticated-orcid":false,"given":"Anne-Lise","family":"Lecoq","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris-Saclay, Inserm, Physiologie et Physiopathologie Endocriniennes, AP-HP, H\u00f4pital Bic\u00eatre, Service d\u2019Endocrinologie et des Maladies de la Reproduction, Centre de R\u00e9f\u00e9rence des Maladies Rares du M\u00e9tabolisme du Calcium et du Phosphate , 94 276 Le Kremlin Bic\u00eatre Cedex , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8667-0296","authenticated-orcid":false,"given":"Katharina","family":"Schilbach","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik IV, Klinikum der Universit\u00e4t M\u00fcnchen , 80336 Munich , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Rocher","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris-Saclay, BIOMAPS, UMR1281, AP-HP, H\u00f4pital Antoine B\u00e9cl\u00e8re, Service de Radiologie , 92140 Clamart , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9verine","family":"Trabado","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris-Saclay, Inserm, Physiologie et Physiopathologie Endocriniennes, AP-HP, H\u00f4pital Bic\u00eatre, Laboratoire de G\u00e9n\u00e9tique Mol\u00e9culaire, Pharmacog\u00e9n\u00e9tique et Hormonologie , 94275 Le Kremlin Bic\u00eatre Cedex , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6238-2601","authenticated-orcid":false,"given":"Karine","family":"Briot","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, AP-HP, H\u00f4pital Cochin, Service de Rhumatologie, Centre de R\u00e9f\u00e9rence des Maladies Rares du M\u00e9tabolisme du Calcium et du Phosphate Fili\u00e8re OSCAR , 75014 Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7618-9503","authenticated-orcid":false,"given":"Julia","family":"Herrou","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, AP-HP, H\u00f4pital Cochin, Service de Rhumatologie, Centre de R\u00e9f\u00e9rence des Maladies Rares du M\u00e9tabolisme du Calcium et du Phosphate Fili\u00e8re OSCAR , 75014 Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lie","family":"Forbes","sequence":"additional","affiliation":[{"name":"AP-HP, H\u00f4pital Bic\u00eatre, Service de Biophysique et M\u00e9decine Nucl\u00e9aire , 94275 Le Kremlin Bic\u00eatre Cedex , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Garnier","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris-Saclay, Inserm, Physiologie et Physiopathologie Endocriniennes, AP-HP, H\u00f4pital Bic\u00eatre, Laboratoire de G\u00e9n\u00e9tique Mol\u00e9culaire, Pharmacog\u00e9n\u00e9tique et Hormonologie , 94275 Le Kremlin Bic\u00eatre Cedex , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9410-4796","authenticated-orcid":false,"given":"Marie","family":"Piketty","sequence":"additional","affiliation":[{"name":"AP-HP, H\u00f4pital Necker, Service d\u2019Explorations fonctionnelles Physiologie et Neurophysiologie , 75015 Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4681-6668","authenticated-orcid":false,"given":"Martin","family":"Bidlingmaier","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik IV, Klinikum der Universit\u00e4t M\u00fcnchen , 80336 Munich , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anya","family":"Rothenbuhler","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris-Saclay, Inserm, Physiologie et Physiopathologie Endocriniennes, AP-HP, H\u00f4pital Bic\u00eatre, Service d\u2019Endocrinologie et Diab\u00e9tologie de l\u2019Enfant, Centre de R\u00e9f\u00e9rence des Maladies Rares du M\u00e9tabolisme du Calcium et du Phosphate, Plateforme d\u2019Expertise Paris Saclay Maladies Rares et Fili\u00e8re OSCAR , 94275 Le Kremlin Bic\u00eatre Cedex , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3455-002X","authenticated-orcid":false,"given":"Agn\u00e8s","family":"Linglart","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris-Saclay, Inserm, Physiologie et Physiopathologie Endocriniennes, AP-HP, H\u00f4pital Bic\u00eatre, Service d\u2019Endocrinologie et Diab\u00e9tologie de l\u2019Enfant, Centre de R\u00e9f\u00e9rence des Maladies Rares du M\u00e9tabolisme du Calcium et du Phosphate, Plateforme d\u2019Expertise Paris Saclay Maladies Rares et Fili\u00e8re OSCAR , 94275 Le Kremlin Bic\u00eatre Cedex , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Carette","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris-Cit\u00e9, AP-HP, H\u00f4pital Europ\u00e9en Georges Pompidou, Service de Nutrition, Centre Sp\u00e9cialis\u00e9 Ob\u00e9sit\u00e9 , 75015 Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Chaumet-Riffaud","sequence":"additional","affiliation":[{"name":"IHU FOReSIGHT, INSERM-DHOS CIC 1423, H\u00f4pital National de la Vision des Quinze-Vingts , 75012 Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1994-4226","authenticated-orcid":false,"given":"Peter","family":"Kamenick\u00fd","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris-Saclay, Inserm, Physiologie et Physiopathologie Endocriniennes, AP-HP, H\u00f4pital Bic\u00eatre, Service d\u2019Endocrinologie et des Maladies de la Reproduction, Centre de R\u00e9f\u00e9rence des Maladies Rares du M\u00e9tabolisme du Calcium et du Phosphate , 94 276 Le Kremlin Bic\u00eatre Cedex , 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