{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T22:38:29Z","timestamp":1779921509963,"version":"3.53.1"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T00:00:00Z","timestamp":1722297600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008730","name":"Norwegian Cancer Society","doi-asserted-by":"publisher","award":["182360-2016"],"award-info":[{"award-number":["182360-2016"]}],"id":[{"id":"10.13039\/100008730","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005036","name":"University of Bergen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005036","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Little is known about thyroid cancer survivors' risk of chronic conditions. We, therefore, investigated the prevalence of drugs used for chronic conditions among thyroid cancer patients using population-wide register data.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We linked data from the Cancer Registry of Norway to the Norwegian Prescription Database and other databases for a study population of 3.52 million individuals, including 3486 individuals with thyroid cancer diagnosed during 2005-2019. Prevalence ratios (PRs) with 95% CIs of reimbursed prescribed drugs in thyroid cancer patients up to 15 years after thyroid cancer diagnosis were estimated by log-binomial regression, with the cancer-free population as reference.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Individuals (both males and females) with thyroid cancer had higher use of drugs for several chronic conditions in the years after diagnosis; eg, 5 years after thyroid cancer diagnosis, there was elevated use of drugs for hypoparathyroidism (PRmales = 35.4, 95% CI, 25.2-49.7; PRfemales = 42.8, 95% CI, 34.2-53.6), hypertension (PRfemales = 1.20, 95% CI, 1.12-1.28), anxiety and tension (PRmales = 4.01, 95% CI, 1.80-8.92; PRfemales = 2.01, 95% CI, 1.15-3.52), gastric acid disorders (PRmales = 1.52, 95% CI, 1.22-1.91; PRfemales = 1.45, 95% CI, 1.27-1.66), and pain (PRmales = 1.48, 95% CI, 1.11-1.97; PRfemales = 1.24, 95% CI, 1.08-1.42) as compared with the cancer-free population. In addition, males with thyroid cancer had long-term elevated use of drugs for depression (eg, year 10+, PRmales = 1.66, 95% CI, 1.06-2.59). Individuals with thyroid cancer also had higher use of drugs for several conditions prior to the thyroid cancer diagnosis, eg, hypertension, gastric acid disorders, and pain.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Individuals diagnosed with thyroid cancer had elevated long-term use of drugs for several chronic conditions, as compared with the cancer-free population.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejendo\/lvae092","type":"journal-article","created":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T19:45:07Z","timestamp":1722368707000},"page":"166-174","source":"Crossref","is-referenced-by-count":2,"title":["Prevalence of drugs used for chronic conditions after diagnosis of thyroid cancer: a register-based cohort study"],"prefix":"10.1093","volume":"191","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8045-6643","authenticated-orcid":false,"given":"Tor-Arne","family":"Hegvik","sequence":"first","affiliation":[{"name":"Department of Global Public Health and Primary Care, University of Bergen , Bergen 5020 , Norway"},{"name":"Clinic of Surgery, St. Olav's University Hospital , Trondheim 7006 , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YanYan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Global Public Health and Primary Care, University of Bergen , Bergen 5020 , Norway"},{"name":"Department of Statistics and Biostatistics, Cal State East Bay , Hayward, CA 94542 , United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin","family":"Brauckhoff","sequence":"additional","affiliation":[{"name":"Department of Breast and Endocrine Surgery, Haukeland University Hospital , Bergen 5021 , Norway"},{"name":"Department of Clinical Sciences, University of Bergen , Bergen 5020 , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2245-0179","authenticated-orcid":false,"given":"Kari","family":"Furu","sequence":"additional","affiliation":[{"name":"Department of Chronic Diseases, Norwegian Institute of Public Health , Oslo 0473 , Norway"},{"name":"Centre for Fertility and Health, Norwegian Institute of Public Health , Oslo 0473 , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2379-9906","authenticated-orcid":false,"given":"Vidar","family":"Hjellvik","sequence":"additional","affiliation":[{"name":"Department of Chronic Diseases, Norwegian Institute of Public Health , Oslo 0473 , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9096-5257","authenticated-orcid":false,"given":"Tone","family":"Bj\u00f8rge","sequence":"additional","affiliation":[{"name":"Department of Global Public Health and Primary Care, University of Bergen , Bergen 5020 , Norway"},{"name":"Cancer Registry of Norway, Norwegian Institute of Public Health , Oslo 0379 , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5620-9207","authenticated-orcid":false,"given":"Anders","family":"Engeland","sequence":"additional","affiliation":[{"name":"Department of Global Public Health and Primary Care, University of Bergen , Bergen 5020 , Norway"},{"name":"Department of Chronic Diseases, Norwegian Institute of Public Health , Oslo 0473 , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,7,30]]},"reference":[{"issue":"3","key":"2024082910343624100_lvae092-B1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J Clin"},{"key":"2024082910343624100_lvae092-B2","author":"Cancer Registry of Norway"},{"issue":"7","key":"2024082910343624100_lvae092-B3","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1158\/1055-9965.EPI-21-1440","article-title":"Epidemiology of thyroid cancer","volume":"31","author":"Kitahara","year":"2022","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"1","key":"2024082910343624100_lvae092-B4","doi-asserted-by":"crossref","first-page":"15077","DOI":"10.1038\/nrdp.2015.77","article-title":"Follicular cell-derived thyroid cancer","volume":"1","author":"Dralle","year":"2015","journal-title":"Nat Rev Dis Primers"},{"issue":"6","key":"2024082910343624100_lvae092-B5","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/S2213-8587(20)30115-7","article-title":"Global trends in thyroid cancer incidence and the impact of overdiagnosis","volume":"8","author":"Li","year":"2020","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"5","key":"2024082910343624100_lvae092-B6","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1002\/ijc.33690","article-title":"Thyroid cancer, recent advances in diagnosis and therapy","volume":"149","author":"Nabhan","year":"2021","journal-title":"Int J Cancer"},{"issue":"1","key":"2024082910343624100_lvae092-B7","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1210\/jc.2007-1203","article-title":"Quality of life in cured patients with differentiated thyroid carcinoma","volume":"93","author":"Hoftijzer","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"2024082910343624100_lvae092-B8","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1001\/jamaoto.2018.3870","article-title":"Health-related quality of life after diagnosis and treatment of differentiated thyroid cancer and association with type of surgical treatment","volume":"145","author":"Nickel","year":"2019","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"issue":"2","key":"2024082910343624100_lvae092-B9","doi-asserted-by":"crossref","first-page":"249","DOI":"10.3109\/0284186X.2012.741326","article-title":"Health-related quality of life and disease specific symptoms in long-term thyroid cancer survivors: a study from the population-based PROFILES registry","volume":"52","author":"Husson","year":"2013","journal-title":"Acta Oncol"},{"issue":"6","key":"2024082910343624100_lvae092-B10","doi-asserted-by":"crossref","first-page":"e1144","DOI":"10.1097\/SLA.0000000000003777","article-title":"Use and misuse of opioids after endocrine surgery operations","volume":"274","author":"Kuo","year":"2021","journal-title":"Ann Surg"},{"issue":"10","key":"2024082910343624100_lvae092-B11","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1007\/s00268-022-06643-5","article-title":"Long-term health-related quality of life outcomes following thyroid surgery for malignant or benign disease: deficits persist in cancer survivors beyond five years","volume":"46","author":"Blefari","year":"2022","journal-title":"World J Surg"},{"issue":"1","key":"2024082910343624100_lvae092-B12","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1186\/s12885-020-07401-3","article-title":"Long-term all-cause mortality and its association with cardiovascular risk factors in thyroid cancer survivors: an Israeli population-based study","volume":"20","author":"Izkhakov","year":"2020","journal-title":"BMC Cancer"},{"issue":"6","key":"2024082910343624100_lvae092-B13","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1530\/EJE-19-0550","article-title":"Longitudinal analysis of quality of life in patients treated for differentiated thyroid cancer","volume":"181","author":"van Velsen","year":"2019","journal-title":"Eur J Endocrinol"},{"issue":"8","key":"2024082910343624100_lvae092-B14","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1002\/pds.5243","article-title":"Prescribed drugs in 27 000 individuals after diagnosis of colorectal cancer: a population-based cohort study","volume":"30","author":"Engeland","year":"2021","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"2024082910343624100_lvae092-B15","first-page":"2550","article-title":"Det sentrale folkeregister i medisinsk forskning [The central population registry in medical research]","volume":"122","author":"Hammer","year":"2002","journal-title":"Tidsskr Nor Laegeforen"},{"issue":"7","key":"2024082910343624100_lvae092-B16","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1016\/j.ejca.2008.10.037","article-title":"Data quality at the Cancer Registry of Norway: an overview of comparability, completeness, validity and timeliness","volume":"45","author":"Larsen","year":"2009","journal-title":"Eur J Cancer"},{"issue":"2","key":"2024082910343624100_lvae092-B17","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1111\/j.1742-7843.2009.00494.x","article-title":"The Nordic countries as a cohort for pharmacoepidemiological research","volume":"106","author":"Furu","year":"2010","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"2024082910343624100_lvae092-B18","author":"Statistics Norway"},{"key":"2024082910343624100_lvae092-B19","article-title":"Sykehjem og hjemmetjenesten i Norge [Nursing homes and home services in Norway]","author":"Statistics Norway","year":"2023"},{"issue":"1","key":"2024082910343624100_lvae092-B20","first-page":"37","article-title":"Coding and classification in drug statistics\u2014from national to global application","volume":"11","author":"R\u00f8nning","year":"2001","journal-title":"Norwegian J Epidemiol"},{"issue":"7","key":"2024082910343624100_lvae092-B21","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1097\/MLR.0000000000000149","article-title":"Development of a pharmacy-based comorbidity index for patients with cancer","volume":"52","author":"Sarfati","year":"2014","journal-title":"Med Care"},{"key":"2024082910343624100_lvae092-B22","article-title":"PPRI Pharma Profile Norway. Ed TNM Agency: the Pharmaceutical Pricing and Reimbursement Information (PPRI) networks","author":"Weise","year":"2018"},{"key":"2024082910343624100_lvae092-B23","volume-title":"Age Standardization of Rates: A New WHO Standard. Ed GDP Series","author":"Ahmad","year":"2001"},{"issue":"9","key":"2024082910343624100_lvae092-B24","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1136\/jech.2005.041319","article-title":"Education, income, and occupational class cannot be used interchangeably in social epidemiology. Empirical evidence against a common practice","volume":"60","author":"Geyer","year":"2006","journal-title":"J Epidemiol Community Health"},{"key":"2024082910343624100_lvae092-B25","author":"The Norwegian Directorate of Health","year":"2017"},{"issue":"3","key":"2024082910343624100_lvae092-B26","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.surg.2019.03.002","article-title":"The 2015 American Thyroid Association guidelines are associated with an increasing rate of hemithyroidectomy for thyroid cancer","volume":"166","author":"Ullmann","year":"2019","journal-title":"Surgery"},{"issue":"6","key":"2024082910343624100_lvae092-B27","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1002\/bjs.12028","article-title":"Central lymph node dissection and permanent hypoparathyroidism after total thyroidectomy for papillary thyroid cancer: population-based study","volume":"108","author":"Salem","year":"2021","journal-title":"Br J Surg"},{"issue":"3","key":"2024082910343624100_lvae092-B28","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/sj.bjc.6603249","article-title":"Body size and thyroid cancer in two million Norwegian men and women","volume":"95","author":"Engeland","year":"2006","journal-title":"Br J Cancer"},{"issue":"1","key":"2024082910343624100_lvae092-B29","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1038\/s41598-018-38203-0","article-title":"Weight change is significantly associated with risk of thyroid cancer: a nationwide population-based cohort study","volume":"9","author":"Kwon","year":"2019","journal-title":"Sci Rep"},{"issue":"4","key":"2024082910343624100_lvae092-B30","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1007\/s11136-005-3689-7","article-title":"Health-related quality of life, depression and anxiety in thyroid cancer patients","volume":"15","author":"Tagay","year":"2006","journal-title":"Qual Life Res"},{"issue":"9","key":"2024082910343624100_lvae092-B31","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1089\/thy.2022.0067","article-title":"Predictors of anxiety and depression in differentiated thyroid cancer survivors: results of a cross-sectional study","volume":"32","author":"Noto","year":"2022","journal-title":"Thyroid"},{"issue":"3","key":"2024082910343624100_lvae092-B32","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s12020-021-02786-y","article-title":"Distress, anxiety, depression and unmet needs in thyroid cancer survivors: a longitudinal study","volume":"74","author":"Dionisi-Vici","year":"2021","journal-title":"Endocrine"},{"issue":"7","key":"2024082910343624100_lvae092-B33","doi-asserted-by":"crossref","first-page":"4386","DOI":"10.3390\/curroncol29070350","article-title":"Health-related quality of life following total thyroidectomy and lobectomy for differentiated thyroid carcinoma: a systematic review","volume":"29","author":"Landry","year":"2022","journal-title":"Curr Oncol"},{"issue":"1","key":"2024082910343624100_lvae092-B34","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1002\/lio2.1009","article-title":"Post-thyroidectomy voice and swallowing disorders and association with laryngopharyngeal reflux: a scopin review","volume":"8","author":"Rodriguez","year":"2023","journal-title":"Laryngoscope Investig Otolaryngol"},{"issue":"7","key":"2024082910343624100_lvae092-B35","doi-asserted-by":"crossref","first-page":"e0254235","DOI":"10.1371\/journal.pone.0254235","article-title":"Aggravation of reflux finding score (RFS) after thyroidectomy","volume":"16","author":"Yoon","year":"2021","journal-title":"PLoS One"},{"issue":"3","key":"2024082910343624100_lvae092-B36","doi-asserted-by":"crossref","first-page":"365","DOI":"10.3109\/0284186X.2015.1102965","article-title":"Determinants of long-term quality of life in patients with differentiated thyroid carcinoma\u2014a population-based cohort study in Sweden","volume":"55","author":"Hedman","year":"2016","journal-title":"Acta Oncol"},{"issue":"7","key":"2024082910343624100_lvae092-B37","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1111\/1471-0528.17410","article-title":"Incidence and prevalence of drugs used for chronic diseases in survivors of adult-onset gynaecological cancer\u2014a nationwide cohort study","volume":"130","author":"Bj\u00f8rge","year":"2023","journal-title":"BJOG"},{"issue":"8","key":"2024082910343624100_lvae092-B38","first-page":"1","article-title":"Norway: health system review","volume":"15","author":"Ringard","year":"2013","journal-title":"Health Syst Transit"},{"issue":"9859","key":"2024082910343624100_lvae092-B39","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1016\/S0140-6736(12)61899-6","article-title":"GBD 2010: design, definitions, and metrics","volume":"380","author":"Murray","year":"2012","journal-title":"Lancet"}],"container-title":["European Journal of Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ejendo\/advance-article-pdf\/doi\/10.1093\/ejendo\/lvae092\/58683531\/lvae092.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ejendo\/article-pdf\/191\/2\/166\/58814793\/lvae092.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ejendo\/article-pdf\/191\/2\/166\/58814793\/lvae092.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T12:29:02Z","timestamp":1724934542000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/191\/2\/166\/7723725"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,30]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,8,5]]}},"URL":"https:\/\/doi.org\/10.1093\/ejendo\/lvae092","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,8]]},"published":{"date-parts":[[2024,7,30]]}}}