{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T13:28:12Z","timestamp":1768829292854,"version":"3.49.0"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,8,21]],"date-time":"2024-08-21T00:00:00Z","timestamp":1724198400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Previous studies indicate a possible bidirectional stimulatory relationship between parathyroid hormone (PTH) and adrenocortical hormones, but the pattern of adrenocortical secretion in hypoparathyroidism is unknown. We aimed to characterize the adrenocortical secretion in patients with postsurgical hypoparathyroidism, and whether continuous subcutaneous PTH (1-34) infusion alters secretion patterns.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>Crossover interventional study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We recruited 10 patients with postsurgical hypoparathyroidism with very low PTH levels on stable treatment with active vitamin D and calcium. Cortisol, cortisone, and aldosterone levels were measured in microdialysate from subcutaneous tissue over 24\u2005h, before and during continuous subcutaneous PTH (1-34) infusion. Cortisol was also assayed in serum, saliva, and urine, and aldosterone and ACTH in serum and plasma, respectively. Ten patients with primary hyperparathyroidism and 10 healthy volunteers matched for sex and age served as controls.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Hypoparathyroid patients displayed both ultradian and circadian rhythmicity for tissue cortisol, cortisone, and aldosterone. Tissue aldosterone and cortisone levels were significantly lower in hypoparathyroid patients than in healthy controls, with no difference in tissue cortisol, but a higher cortisol to cortisone ratio. Treatment with PTH (1-34) increased tissue levels of aldosterone, cortisol, and cortisone and reduced the ratio of cortisol to cortisone.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Adrenocortical hormone levels are reduced in postsurgical hypoparathyroidism, and partly restored by short-term continuous subcutaneous PTH (1-34) therapy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Clinical trial registration number<\/jats:title>\n                  <jats:p>NCT02986607<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejendo\/lvae102","type":"journal-article","created":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T14:51:58Z","timestamp":1724079118000},"page":"271-278","source":"Crossref","is-referenced-by-count":2,"title":["Corticosteroid rhythms in hypoparathyroid patients"],"prefix":"10.1093","volume":"191","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6129-9806","authenticated-orcid":false,"given":"Marianne C","family":"Astor","sequence":"first","affiliation":[{"name":"Department of Clinical Medicine and KG Jebsen-Center for Autoimmune Diseases, University of Bergen , 5020 Bergen ,","place":["Norway"]},{"name":"Department of Medicine, Haukeland University Hospital , 5021 Bergen ,","place":["Norway"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristian","family":"L\u00f8v\u00e5s","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine and KG Jebsen-Center for Autoimmune Diseases, University of Bergen , 5020 Bergen ,","place":["Norway"]},{"name":"Department of Medicine, Haukeland University Hospital , 5021 Bergen ,","place":["Norway"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paal","family":"Methlie","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine and KG Jebsen-Center for Autoimmune Diseases, University of Bergen , 5020 Bergen ,","place":["Norway"]},{"name":"Department of Medicine, Haukeland University Hospital , 5021 Bergen ,","place":["Norway"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katerina","family":"Simunkova","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine and KG Jebsen-Center for Autoimmune Diseases, University of Bergen , 5020 Bergen ,","place":["Norway"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f6rg","family":"Assmus","sequence":"additional","affiliation":[{"name":"Centre for Clinical Research, Haukeland University Hospital , 5021 Bergen ,","place":["Norway"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eystein S","family":"Husebye","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine and KG Jebsen-Center for Autoimmune Diseases, University of Bergen , 5020 Bergen ,","place":["Norway"]},{"name":"Department of Medicine, Haukeland University Hospital , 5021 Bergen ,","place":["Norway"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,8,21]]},"reference":[{"issue":"8","key":"2024093003555296600_lvae102-B1","doi-asserted-by":"crossref","first-page":"3045","DOI":"10.1210\/jc.2016-1477","article-title":"Epidemiology and health-related quality of life in hypoparathyroidism in Norway","volume":"101","author":"Astor","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"2024093003555296600_lvae102-B2","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1530\/eje.0.1460215","article-title":"Well-being, mood and calcium homeostasis in patients with hypoparathyroidism receiving standard treatment with calcium and vitamin D","volume":"146","author":"Arlt","year":"2002","journal-title":"Eur J 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