{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T12:43:41Z","timestamp":1740141821793,"version":"3.37.3"},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T00:00:00Z","timestamp":1724284800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273639","82103856"],"award-info":[{"award-number":["82273639","82103856"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Anhui Institute of translational medicine","award":["ZHYX2020A001"],"award-info":[{"award-number":["ZHYX2020A001"]}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program","doi-asserted-by":"publisher","award":["2022YFC2702901"],"award-info":[{"award-number":["2022YFC2702901"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002947","name":"Anhui Medical University","doi-asserted-by":"publisher","award":["2023xkjT005"],"award-info":[{"award-number":["2023xkjT005"]}],"id":[{"id":"10.13039\/501100002947","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Scientific Research Platform Base Construction Foundation","award":["2023xkjT053","2022-ZQKY-82"],"award-info":[{"award-number":["2023xkjT053","2022-ZQKY-82"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To explore the association between maternal thyroid peroxidase antibody (TPOAb) exposure and 5- to 6-year-old children's cardiometabolic risk (CMR).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A total of 2129 mother\u2013child pairs were recruited from the Ma'anshan Birth Cohort (MABC) study. Serum TPOAb was retrospectively measured in pregnant women using an electrochemiluminescence immunoassay. CMR score was evaluated by the serum glycolipids, blood pressure, and waist circumference for children aged 5-6 years. Growth mixture modelling was used to fit trajectories of TPOAb levels throughout pregnancy. Multiple linear regression models and logistic regression models were used for statistical analyses.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Two thousand one hundred twenty-nine mother\u2013child pairs (mean [SD] age, 26.6 [3.6] years) were enrolled for the final study. Maternal TPOAb exposure in the first trimester increased children's overall CMR, glucose level, HOMA-IR, triglyceride level, boys\u2019 overall CMR, boys\u2019 glucose level, and girls\u2019 glucose level. TPOAb exposure in the first trimester was also associated with lower boys\u2019 high-density lipoprotein cholesterol (HDL-C) level. In the second trimester, maternal TPOAb exposure was positively associated with children's triglyceride level. Compared with low TPOAb trajectory, children with high maternal TPOAb trajectory had an increased risk of developing high CMR (OR = 3.40; 95% CI, 1.30-8.90), hyperglycemia (OR = 5.20; 95% CI, 2.20-12.28), insulin-resistance (adjusted OR = 2.12; 95% CI, 1.10-4.07), and hypertriglyceridemia (OR = 2.55; 95% CI, 1.06-6.14).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The first trimester of pregnancy is a critical period for maternal TPOAb exposure to affect CMR in children, with some sex specificity, mainly to the detriment of boys.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejendo\/lvae105","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T23:15:27Z","timestamp":1724368527000},"page":"323-333","source":"Crossref","is-referenced-by-count":0,"title":["Sex-specific effect of maternal thyroid peroxidase antibody exposure during pregnancy on 5- to 6-year-old children's cardiometabolic risk score: the Ma'anshan birth cohort study"],"prefix":"10.1093","volume":"191","author":[{"given":"Yuzhu","family":"Teng","sequence":"first","affiliation":[{"name":"Department of Maternal, Child & Adolescent Health, School of Public Health, Anhui Medical University , No 81 Meishan Road, Hefei 230032, Anhui ,","place":["China"]},{"name":"Key Laboratory of Population Health Across Life Cycle, Anhui Medical University, Ministry of Education of the People's Republic of China , No 81 Meishan Road, Hefei 230032, Anhui ,","place":["China"]},{"name":"NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract , No 81 Meishan Road, Hefei 230032, Anhui ,","place":["China"]},{"name":"Anhui Provincial Key Laboratory of Environment and Population Health Across the Life Courset , No 81 Meishan Road, Hefei 230032, Anhui ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jixing","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Maternal, Child & Adolescent Health, School of Public Health, Anhui Medical University , No 81 Meishan Road, Hefei 230032, Anhui ,","place":["China"]},{"name":"Key Laboratory of Population Health Across Life Cycle, Anhui Medical University, Ministry of Education of the People's Republic of China , No 81 Meishan Road, Hefei 230032, Anhui ,","place":["China"]},{"name":"NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract , No 81 Meishan Road, Hefei 230032, Anhui ,","place":["China"]},{"name":"Anhui Provincial Key Laboratory of Environment and Population Health Across the Life Courset , No 81 Meishan Road, Hefei 230032, Anhui ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Maternal, 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Environment and Population Health Across the Life Courset , No 81 Meishan Road, Hefei 230032, Anhui ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Tong","sequence":"additional","affiliation":[{"name":"Department of Maternal, Child & Adolescent Health, School of Public Health, Anhui Medical University , No 81 Meishan Road, Hefei 230032, Anhui ,","place":["China"]},{"name":"Key Laboratory of Population Health Across Life Cycle, Anhui Medical University, Ministry of Education of the People's Republic of China , No 81 Meishan Road, Hefei 230032, Anhui ,","place":["China"]},{"name":"NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract , No 81 Meishan Road, Hefei 230032, Anhui ,","place":["China"]},{"name":"Anhui Provincial Key Laboratory of Environment and Population Health Across the Life Courset , No 81 Meishan Road, Hefei 230032, Anhui 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