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After removal of duplicates, 11 868 titles and abstracts and 445 full texts were assessed. Of these, 24 articles reporting on 23 studies from five world regions were included. In meta-analysis of 20 studies (n = 14 010 adolescents), global prevalence was 9.8% (95% CI 7.2, 12.3) according to original Rotterdam criteria, and 6.3% (95% CI 3.9, 8.8) according to International Evidence-based Guideline criteria. Global PCOS prevalence based on self-report was 9.8% (95% CI 5.5, 14.1). Grouped by WHO region, prevalence ranged from 2.9% (95% CI 2.0, 3.9) in the Western Pacific region to 11.4% (95% CI 7.1, 15.7) in the South-East Asia region according to guideline criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This paramount global meta-analysis on adolescent PCOS diagnosis directly informed the 2023 International PCOS Guideline. Guideline criteria generated a global PCOS prevalence of 6.3%, compared with 9.8% on Rotterdam criteria (including PCOM). Excluding PCOM, which overlaps with normal pubertal transition, is expected to deter over-diagnosis. To avoid under-diagnosis, the Guideline recommends identifying those with either irregular cycles or hyperandrogenism as being \u201cat risk\u201d; this group should undergo longitudinal serial evaluations until adulthood.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ejendo\/lvae125","type":"journal-article","created":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T07:18:20Z","timestamp":1727421500000},"page":"S15-S27","source":"Crossref","is-referenced-by-count":65,"title":["Prevalence and accurate diagnosis of polycystic ovary syndrome in adolescents across world regions: a systematic review and meta-analysis"],"prefix":"10.1093","volume":"191","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3480-4245","authenticated-orcid":false,"given":"Adriana C H","family":"Neven","sequence":"first","affiliation":[{"name":"Monash Centre for Health Research and Implementation, Faculty of Medicine, Nursing and Health Sciences, Monash University , Level 1, 43-51 Kanooka Grove, 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Level 1, 43-51 Kanooka Grove, Clayton, VIC 3168 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7356-4523","authenticated-orcid":false,"given":"Aya","family":"Mousa","sequence":"additional","affiliation":[{"name":"Monash Centre for Health Research and Implementation, Faculty of Medicine, Nursing and Health Sciences, Monash University , Level 1, 43-51 Kanooka Grove, Clayton, VIC 3168 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6228-2654","authenticated-orcid":false,"given":"Chau Thien","family":"Tay","sequence":"additional","affiliation":[{"name":"Monash Centre for Health Research and Implementation, Faculty of Medicine, Nursing and Health Sciences, Monash University , Level 1, 43-51 Kanooka Grove, Clayton, VIC 3168 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6834-4876","authenticated-orcid":false,"given":"Alexia","family":"Pe\u00f1a","sequence":"additional","affiliation":[{"name":"Discipline of Paediatrics, The University of Adelaide Robinson Research Institute and Endocrine Department, Women's and Children's Hospital , 72 King William Road, North Adelaide, SA 5006 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9652-1107","authenticated-orcid":false,"given":"Sharon","family":"Oberfield","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology, Columbia University Irving Medical Center, Morgan Stanley Children's Hospital , New York, NY 10032 ,","place":["United 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