{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T22:20:33Z","timestamp":1785450033651,"version":"3.56.0"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T00:00:00Z","timestamp":1731888000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"German Ministry of Research and Education"},{"name":"Comprehensive Heart Failure Centre W\u00fcrzburg","award":["01EO1004"],"award-info":[{"award-number":["01EO1004"]}]},{"name":"Comprehensive Heart Failure Centre W\u00fcrzburg","award":["01EO1504"],"award-info":[{"award-number":["01EO1504"]}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["314061271"],"award-info":[{"award-number":["314061271"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Clinician Scientist Programme on Rare Important Syndromes in Endocrinology"},{"name":"Else Kr\u00f6ner-Fresenius-Stiftung & Eva Luise und Horst K\u00f6hler Stiftung"},{"name":"Interdisciplinary Center for Clinical Research"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Cushing's syndrome (CS) results in increased cardiovascular (CV) morbidity and mortality. Subtype-specific differences and possible reversibility after biochemical cure are not well investigated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>Prospective cohort study evaluating the CV status in different forms of endogenous cortisol excess.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Patients with overt CS (n = 40, 47 \u00b1 13 years, 75% women; 18 pituitary, 13 adrenal, and 9 ectopic), biochemically cured CS (n = 56, 53 \u00b1 12 years, 79% women; 30 pituitary, 21 adrenal, and 5 ectopic), and adrenal incidentalomas with mild autonomous cortisol secretion (MACS) (n = 18, 62 \u00b1 11 years, 56% women) underwent comprehensive biochemical, metabolic, and CV assessment. Results were compared with a representative sample of the general population of W\u00fcrzburg (n = 4965, 55 \u00b1 12 years, 52% women).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Overt CS was associated with left ventricular (LV) remodeling along with hypertrophy and impaired longitudinal systolic\/diastolic function at echocardiography. In 20 CS patients followed for a median of 8 (quartiles: 6, 11) months after biochemical remission, hypertension, and hyperglycemia were better controlled, while cardiac alterations only partially improved. Patients with previous CS (median time of biochemical remission: 95 [36, 201] months) had worse diastolic function than the general population (LV relaxation velocity e\u2032 0.08 [0.07, 0.10] ms\u22121 vs 0.10 [0.08, 0.12] ms\u22121, P &amp;lt; .001). In MACS, cardiac remodeling was even more pronounced than in individuals with metabolic syndrome.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>In patients with overt CS, cured CS, and MACS, we found a sizable and significant deviation from the general population mean regarding cardiac structure and function. Even mild cortisol excess is associated with glucocorticoid-induced cardiac alterations, which appear to persist despite long-term biochemical remission.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejendo\/lvae145","type":"journal-article","created":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T20:28:59Z","timestamp":1731961739000},"page":"604-613","source":"Crossref","is-referenced-by-count":10,"title":["Cardiovascular status in endogenous cortisol excess: the prospective CV-CORT-EX study"],"prefix":"10.1093","volume":"191","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0920-6094","authenticated-orcid":false,"given":"Caroline","family":"Morbach","sequence":"first","affiliation":[{"name":"Department of Clinical Research and Epidemiology, Comprehensive Heart Failure Center W\u00fcrzburg , 97078 W\u00fcrzburg ,","place":["Germany"]},{"name":"Department of Internal Medicine I, Division of Cardiology, University Hospital W\u00fcrzburg , 97080 W\u00fcrzburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1490-5575","authenticated-orcid":false,"given":"Mario","family":"Detomas","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Division of Endocrinology and Diabetes, University Hospital, University of W\u00fcrzburg , 97080 W\u00fcrzburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2033-9354","authenticated-orcid":false,"given":"Floran","family":"Sahiti","sequence":"additional","affiliation":[{"name":"Department of Clinical Research and Epidemiology, Comprehensive Heart Failure Center W\u00fcrzburg , 97078 W\u00fcrzburg ,","place":["Germany"]},{"name":"Department of Internal Medicine I, Division of Cardiology, University Hospital W\u00fcrzburg , 97080 W\u00fcrzburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Division of Endocrinology and Diabetes, University Hospital, University of W\u00fcrzburg , 97080 W\u00fcrzburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Kroiss","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Division of Endocrinology and Diabetes, University Hospital, University of W\u00fcrzburg , 97080 W\u00fcrzburg ,","place":["Germany"]},{"name":"Department of Internal Medicine IV, University Hospital Munich, Ludwig Maximilians-Universit\u00e4t M\u00fcnchen , 80336 M\u00fcnchen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f6tz","family":"Gelbrich","sequence":"additional","affiliation":[{"name":"Clinical Trial Center, University Hospital W\u00fcrzburg , 97080 W\u00fcrzburg ,","place":["Germany"]},{"name":"Institute for Clinical Epidemiology and Biometry, University of W\u00fcrzburg , 97080 W\u00fcrzburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0301-6185","authenticated-orcid":false,"given":"Stefan","family":"Frantz","sequence":"additional","affiliation":[{"name":"Department of Clinical Research and Epidemiology, Comprehensive Heart Failure Center W\u00fcrzburg , 97078 W\u00fcrzburg ,","place":["Germany"]},{"name":"Department of Internal Medicine I, Division of Cardiology, University Hospital W\u00fcrzburg , 97080 W\u00fcrzburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Hahner","sequence":"additional","affiliation":[{"name":"Department of Clinical Research and Epidemiology, Comprehensive Heart Failure Center W\u00fcrzburg , 97078 W\u00fcrzburg ,","place":["Germany"]},{"name":"Department of Internal Medicine I, Division of Endocrinology and Diabetes, University Hospital, University of W\u00fcrzburg , 97080 W\u00fcrzburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter Ulrich","family":"Heuschmann","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine IV, University Hospital Munich, Ludwig Maximilians-Universit\u00e4t M\u00fcnchen , 80336 M\u00fcnchen ,","place":["Germany"]},{"name":"Clinical Trial Center, University Hospital W\u00fcrzburg , 97080 W\u00fcrzburg ,","place":["Germany"]},{"name":"Institute for Clinical Epidemiology and Biometry, University of W\u00fcrzburg , 97080 W\u00fcrzburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6170-6398","authenticated-orcid":false,"given":"Martin","family":"Fassnacht","sequence":"additional","affiliation":[{"name":"Department of Clinical 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