{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T03:19:41Z","timestamp":1768879181229,"version":"3.49.0"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T00:00:00Z","timestamp":1743638400000},"content-version":"vor","delay-in-days":7,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Czech Science Agency","award":["23-05609S"],"award-info":[{"award-number":["23-05609S"]}]},{"name":"National Institute for Cancer Research"},{"name":"NICR","award":["LX22NPO5102"],"award-info":[{"award-number":["LX22NPO5102"]}]},{"name":"European Union\u2014Next Generation EU"},{"name":"SALVAGE","award":["CZ.02.01.01\/00\/22_008\/000464"],"award-info":[{"award-number":["CZ.02.01.01\/00\/22_008\/000464"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Thyroid cancer (TC) is the most common endocrine malignancy, with 90%-95% of the cases representing non\u2013medullary thyroid cancer (NMTC). Familial cases account only for a few of all cases and the underlying genetic causes are still poorly understood.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We whole-genome sequenced affected and unaffected members of an Italian NMTC family and applied our in-house developed Familial Cancer Variant Prioritization Pipeline (FCVPPv2) which prioritized 12 coding variants. We refined this selection using the VarSome American College of Medical Genetics and Genomics (ACMG) implementation, SNAP2 predictions and further in silico scores.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We prioritized 4 possibly pathogenic variants in 4 genes including Ret proto-oncogene (RET), polypeptide N-acetylgalactosaminyltransferase 10 (GALNT10), ubinuclein-1 (UBN1), and prostaglandin I2 receptor (PTGIR). The role of RET point mutations in medullary thyroid carcinoma is well established. Similarly, somatic rearrangements of RET are known in papillary TC, a specific histotype of NMTC. In contrast to RET, no germline variants in PTGIR, GALNT10, or UBN1 have been linked to the development of TC to date. However, alterations in these genes have been shown to affect pathways related to cell proliferation, apoptosis, growth, and differentiation, as well as posttranslational modification and gene regulation. A thorough review of the available literature together with computational evidence supported the interpretation of the 4 shortlisted variants as possibly disease-causing in this family.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Our results implicate the first germline variant in RET in a family with NMTC as well as the first germline variants in PTGIR, GALNT10, and UBN1 in TC.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejendo\/lvaf045","type":"journal-article","created":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T11:44:26Z","timestamp":1743507866000},"page":"398-407","source":"Crossref","is-referenced-by-count":2,"title":["Prioritization of predisposition genes for familial non-medullary thyroid cancer by whole-genome sequencing"],"prefix":"10.1093","volume":"192","author":[{"given":"Aayushi","family":"Srivastava","sequence":"first","affiliation":[{"name":"Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ) , Heidelberg 69120 ,","place":["Germany"]},{"name":"Heidelberg University, Medical Faculty , Heidelberg 69120 ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diamanto","family":"Skopelitou","sequence":"additional","affiliation":[{"name":"Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ) , Heidelberg 69120 ,","place":["Germany"]},{"name":"Heidelberg University, Medical Faculty , Heidelberg 69120 ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beiping","family":"Miao","sequence":"additional","affiliation":[{"name":"Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ) , Heidelberg 69120 ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Giagiobbe","sequence":"additional","affiliation":[{"name":"Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ) , Heidelberg 69120 ,","place":["Germany"]},{"name":"Department of Medicine I and Clinical Chemistry, University Hospital of Heidelberg , Heidelberg 69120 ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nagarajan","family":"Paramasivam","sequence":"additional","affiliation":[{"name":"Computational Oncology, Molecular Diagnostics Program, National Center for Tumor Diseases (NCT) , Heidelberg 69120 ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abhishek","family":"Kumar","sequence":"additional","affiliation":[{"name":"Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ) , Heidelberg 69120 ,","place":["Germany"]},{"name":"Clinical Cooperation Unit Molecular Hematology-Oncology, German Cancer Research Center (DKFZ) , Heidelberg 69120 ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Diquigiovanni","sequence":"additional","affiliation":[{"name":"Unit of Medical Genetics, Department of Medical and Surgical Sciences, University of Bologna , Bologna 40126 ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Bonora","sequence":"additional","affiliation":[{"name":"Unit of Medical Genetics, Department of Medical and Surgical Sciences, University of Bologna , Bologna 40126 ,","place":["Italy"]},{"name":"IRCCS Azienda Ospedaliero-Universitaria di Bologna , Bologna 40126 ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Obul Reddy","family":"Bandapalli","sequence":"additional","affiliation":[{"name":"Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ) , Heidelberg 69120 ,","place":["Germany"]},{"name":"Heidelberg University, Medical Faculty , Heidelberg 69120 ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9857-4728","authenticated-orcid":false,"given":"Asta","family":"F\u00f6rsti","sequence":"additional","affiliation":[{"name":"Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ) , Heidelberg 69120 ,","place":["Germany"]},{"name":"Hopp Children's Cancer Center (KiTZ) , Heidelberg 69120 ,","place":["Germany"]},{"name":"Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK) , Heidelberg 69120 ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2769-3316","authenticated-orcid":false,"given":"Kari","family":"Hemminki","sequence":"additional","affiliation":[{"name":"Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ) , Heidelberg 69120 ,","place":["Germany"]},{"name":"Biomedical Center, Faculty of Medicine in Pilsen, Charles University in Prague , Pilsen 32300 ,","place":["Czech Republic"]},{"name":"Division of Cancer Epidemiology, German Cancer Research Center (DKFZ) , Heidelberg 69120 ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,4,3]]},"reference":[{"issue":"3","key":"2025040309092685300_lvaf045-B1","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J Clin"},{"key":"2025040309092685300_lvaf045-B2","doi-asserted-by":"publisher","first-page":"385206","DOI":"10.1155\/2010\/385206","article-title":"Genetic predisposition to familial nonmedullary thyroid cancer: an update of molecular findings and state-of-the-art studies","volume":"2010","author":"Bonora","year":"2010","journal-title":"J Oncol"},{"issue":"9","key":"2025040309092685300_lvaf045-B3","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1089\/thy.2013.0079","article-title":"Familial nonmedullary thyroid carcinoma","volume":"23","author":"Mazeh","year":"2013","journal-title":"Thyroid"},{"issue":"17","key":"2025040309092685300_lvaf045-B4","doi-asserted-by":"publisher","first-page":"4385","DOI":"10.3390\/cancers13174385","article-title":"Familial risks and proportions describing population landscape of familial cancer","volume":"13","author":"Hemminki","year":"2021","journal-title":"Cancers (Basel)"},{"issue":"6","key":"2025040309092685300_lvaf045-B5","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1136\/jmedgenet-2012-101412","article-title":"Risk of thyroid cancer in first-degree relatives of patients with non-medullary thyroid cancer by histology type and age at diagnosis: a joint study from five nordic countries","volume":"50","author":"Fallah","year":"2013","journal-title":"J Med Genet"},{"issue":"7","key":"2025040309092685300_lvaf045-B6","doi-asserted-by":"publisher","first-page":"482","DOI":"10.3390\/genes10070482","article-title":"Current knowledge of germline genetic risk factors for the development of non-medullary thyroid cancer","volume":"10","author":"Hincza","year":"2019","journal-title":"Genes (Basel)"},{"issue":"5","key":"2025040309092685300_lvaf045-B7","doi-asserted-by":"publisher","first-page":"e220058","DOI":"10.1530\/etj-22-0058","article-title":"Genetic signature of differentiated thyroid carcinoma susceptibility: a machine learning approach","volume":"11","author":"Brigante","year":"2022","journal-title":"Eur Thyroid J"},{"issue":"10","key":"2025040309092685300_lvaf045-B8","doi-asserted-by":"publisher","first-page":"E1674","DOI":"10.1210\/jc.2013-1941","article-title":"Genome-wide association study on differentiated thyroid cancer","volume":"98","author":"K\u00f6hler","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"issue":"12","key":"2025040309092685300_lvaf045-B9","doi-asserted-by":"publisher","first-page":"2935","DOI":"10.1002\/ijc.33488","article-title":"Multiethnic genome-wide association study of differentiated thyroid cancer in the EPITHYR consortium","volume":"148","author":"Truong","year":"2021","journal-title":"Int J Cancer"},{"issue":"6","key":"2025040309092685300_lvaf045-B10","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.3390\/cancers12061441","article-title":"A germline mutation in the POT1 gene is a candidate for familial non-medullary thyroid cancer","volume":"12","author":"Srivastava","year":"2020","journal-title":"Cancers (Basel)"},{"key":"2025040309092685300_lvaf045-B11","doi-asserted-by":"publisher","first-page":"600682","DOI":"10.3389\/fendo.2021.600682","article-title":"Whole genome sequencing prioritizes CHEK2, EWSR1, and TIAM1 as possible predisposition genes for familial non-medullary thyroid cancer","volume":"12","author":"Srivastava","year":"2021","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"1","key":"2025040309092685300_lvaf045-B12","doi-asserted-by":"publisher","first-page":"11635","DOI":"10.1038\/s41598-018-29952-z","article-title":"Familial cancer variant prioritization pipeline version 2 (FCVPPv2) applied to a papillary thyroid cancer family","volume":"8","author":"Kumar","year":"2018","journal-title":"Sci Rep"},{"issue":"6","key":"2025040309092685300_lvaf045-B13","doi-asserted-by":"publisher","first-page":"2157","DOI":"10.1210\/jcem.84.6.5798","article-title":"Genetic heterogeneity in familial nonmedullary thyroid carcinoma: exclusion of linkage to RET, MNG1, and TCO in 56 families. NMTC Cconsortium","volume":"84","author":"Lesueur","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"issue":"14","key":"2025040309092685300_lvaf045-B14","doi-asserted-by":"publisher","first-page":"1754","DOI":"10.1093\/bioinformatics\/btp324","article-title":"Fast and accurate short read alignment with Burrows-Wheeler transform","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"issue":"8","key":"2025040309092685300_lvaf045-B15","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1038\/ng.3036","article-title":"Integrating mapping-, assembly- and haplotype-based approaches for calling variants in clinical sequencing applications","volume":"46","author":"Rimmer","year":"2014","journal-title":"Nat Genet"},{"issue":"7571","key":"2025040309092685300_lvaf045-B16","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1038\/nature15393","article-title":"A global reference for human genetic variation","volume":"526","author":"Auton","year":"2015","journal-title":"Nature"},{"issue":"7616","key":"2025040309092685300_lvaf045-B17","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1038\/nature19057","article-title":"Analysis of protein-coding genetic variation in 60,706 humans","volume":"536","author":"Lek","year":"2016","journal-title":"Nature"},{"issue":"1","key":"2025040309092685300_lvaf045-B18","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1093\/nar\/28.1.352","article-title":"dbSNP: a database of single nucleotide polymorphisms","volume":"28","author":"Smigielski","year":"2000","journal-title":"Nucleic Acids Res"},{"issue":"16","key":"2025040309092685300_lvaf045-B19","doi-asserted-by":"publisher","first-page":"e164","DOI":"10.1093\/nar\/gkq603","article-title":"ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data","volume":"38","author":"Wang","year":"2010","journal-title":"Nucleic Acids Res"},{"issue":"10","key":"2025040309092685300_lvaf045-B20","doi-asserted-by":"publisher","first-page":"605","DOI":"10.3390\/biom9100605","article-title":"Whole genome sequencing of familial non-medullary thyroid cancer identifies germline alterations in MAPK\/ERK and PI3K\/AKT signaling pathways","volume":"9","author":"Srivastava","year":"2019","journal-title":"Biomolecules"},{"issue":"3","key":"2025040309092685300_lvaf045-B21","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1038\/ng.2892","article-title":"A general framework for estimating the relative pathogenicity of human genetic variants","volume":"46","author":"Kircher","year":"2014","journal-title":"Nat Genet"},{"issue":"3","key":"2025040309092685300_lvaf045-B22","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1002\/humu.22932","article-title":"dbNSFP v3.0: a one-stop database of functional predictions and annotations for human nonsynonymous and splice-site SNVs","volume":"37","author":"Liu","year":"2016","journal-title":"Hum Mutat"},{"issue":"7","key":"2025040309092685300_lvaf045-B23","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1101\/gr.3577405","article-title":"Distribution and intensity of constraint in mammalian genomic sequence","volume":"15","author":"Cooper","year":"2005","journal-title":"Genome Res"},{"issue":"1","key":"2025040309092685300_lvaf045-B24","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1101\/gr.097857.109","article-title":"Detection of nonneutral substitution rates on mammalian phylogenies","volume":"20","author":"Pollard","year":"2010","journal-title":"Genome Res"},{"issue":"8","key":"2025040309092685300_lvaf045-B25","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1101\/gr.3715005","article-title":"Evolutionarily conserved elements in vertebrate, insect, worm, and yeast genomes","volume":"15","author":"Siepel","year":"2005","journal-title":"Genome Res"},{"issue":"8","key":"2025040309092685300_lvaf045-B26","doi-asserted-by":"publisher","first-page":"e1003709","DOI":"10.1371\/journal.pgen.1003709","article-title":"Genic intolerance to functional variation and the interpretation of personal genomes","volume":"9","author":"Petrovski","year":"2013","journal-title":"PLoS Genet"},{"issue":"11","key":"2025040309092685300_lvaf045-B27","doi-asserted-by":"publisher","first-page":"1978","DOI":"10.1093\/bioinformatics\/bty897","article-title":"VarSome: the human genomic variant search engine","volume":"35","author":"Kopanos","year":"2019","journal-title":"Bioinformatics"},{"key":"2025040309092685300_lvaf045-B28","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1200\/cci.19.00132","article-title":"Integrated informatics analysis of cancer-related variants","volume":"4","author":"Pagel","year":"2020","journal-title":"JCO Clin Cancer Inform"},{"issue":"5","key":"2025040309092685300_lvaf045-B29","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1093\/bioinformatics\/btu703","article-title":"DANN: a deep learning approach for annotating the pathogenicity of genetic variants","volume":"31","author":"Quang","year":"2015","journal-title":"Bioinformatics (Oxford, England)"},{"issue":"4","key":"2025040309092685300_lvaf045-B30","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1016\/j.ajhg.2016.08.016","article-title":"REVEL: an ensemble method for predicting the pathogenicity of rare missense variants","volume":"99","author":"Ioannidis","year":"2016","journal-title":"Am J Hum Genet."},{"issue":"S8","key":"2025040309092685300_lvaf045-B31","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1186\/1471-2164-16-S8-S1","article-title":"Better prediction of functional effects for sequence variants","volume":"16","author":"Hecht","year":"2015","journal-title":"BMC Genomics"},{"issue":"9","key":"2025040309092685300_lvaf045-B32","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1093\/bioinformatics\/btm076","article-title":"COBALT: constraint-based alignment tool for multiple protein sequences","volume":"23","author":"Papadopoulos","year":"2007","journal-title":"Bioinformatics"},{"issue":"3","key":"2025040309092685300_lvaf045-B33","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1093\/bioinformatics\/btt691","article-title":"mCSM: predicting the effects of mutations in proteins using graph-based signatures","volume":"30","author":"Pires","year":"2014","journal-title":"Bioinformatics (Oxford, England)"},{"issue":"Database","key":"2025040309092685300_lvaf045-B34","doi-asserted-by":"publisher","first-page":"D402","DOI":"10.1093\/nar\/gkq985","article-title":"PDBe: Protein Data Bank in Europe","volume":"39","author":"Velankar","year":"2011","journal-title":"Nucleic Acids Res"},{"issue":"21","key":"2025040309092685300_lvaf045-B35","doi-asserted-by":"publisher","first-page":"e31","DOI":"10.1158\/0008-5472.CAN-17-0337","article-title":"Variant review with the integrative genomics viewer","volume":"77","author":"Robinson","year":"2017","journal-title":"Cancer Res"},{"issue":"3","key":"2025040309092685300_lvaf045-B36","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/j.str.2020.11.007","article-title":"Cryo-EM structure of the prostaglandin E receptor EP4 coupled to G protein","volume":"29","author":"Nojima","year":"2021","journal-title":"Structure"},{"issue":"4","key":"2025040309092685300_lvaf045-B37","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1038\/nrendo.2016.11","article-title":"A comprehensive overview of the role of the RET proto-oncogene in thyroid carcinoma","volume":"12","author":"Romei","year":"2016","journal-title":"Nat Rev Endocrinol"},{"issue":"12","key":"2025040309092685300_lvaf045-B38","doi-asserted-by":"publisher","first-page":"1780","DOI":"10.1002\/humu.24486","article-title":"Multiple endocrine neoplasia type 2 (MEN2) and RET specific modifications of the ACMG\/AMP variant classification guidelines and impact on the MEN2 RET database","volume":"43","author":"Margraf","year":"2022","journal-title":"Hum Mutat"},{"key":"2025040309092685300_lvaf045-B39","doi-asserted-by":"publisher","first-page":"924","DOI":"10.3389\/fgene.2019.00924","article-title":"Functional studies on novel RET mutations and their implications for genetic counseling for Hirschsprung disease","volume":"10","author":"Wang","year":"2019","journal-title":"Front Genet"},{"issue":"D1","key":"2025040309092685300_lvaf045-B40","doi-asserted-by":"publisher","first-page":"D480","DOI":"10.1093\/nar\/gkaa1100","article-title":"UniProt: the universal protein knowledgebase in 2021","volume":"49","author":"Consortium","year":"2020","journal-title":"Nucleic Acids Res"},{"issue":"11","key":"2025040309092685300_lvaf045-B41","doi-asserted-by":"publisher","first-page":"a011254","DOI":"10.1101\/cshperspect.a011254","article-title":"MAP kinase pathways","volume":"4","author":"Morrison","year":"2012","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"9","key":"2025040309092685300_lvaf045-B42","doi-asserted-by":"publisher","first-page":"a011189","DOI":"10.1101\/cshperspect.a011189","article-title":"PI3K-PKB\/Akt pathway","volume":"4","author":"Hemmings","year":"2012","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"2","key":"2025040309092685300_lvaf045-B43","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1016\/s0006-3495(98)77551-4","article-title":"A proposed structure for transmembrane segment 7 of G protein-coupled receptors incorporating an asn-Pro\/Asp-Pro motif","volume":"75","author":"Konvicka","year":"1998","journal-title":"Biophys J"},{"issue":"2","key":"2025040309092685300_lvaf045-B44","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.canlet.2016.03.031","article-title":"G protein-coupled receptors as promising cancer targets","volume":"376","author":"Liu","year":"2016","journal-title":"Cancer Lett"},{"issue":"6","key":"2025040309092685300_lvaf045-B45","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1046\/j.1365-2796.1998.00332.x","article-title":"Association of multiple endocrine neoplasia type 2 and Hirschsprung disease","volume":"243","author":"Romeo","year":"1998","journal-title":"J Intern Med"},{"issue":"33","key":"2025040309092685300_lvaf045-B46","doi-asserted-by":"publisher","first-page":"54067","DOI":"10.18632\/oncotarget.10042","article-title":"N-acetylgalactosaminyltransferases in cancer","volume":"7","author":"Hussain","year":"2016","journal-title":"Oncotarget"},{"issue":"1","key":"2025040309092685300_lvaf045-B47","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1038\/nrc1251","article-title":"Mucins in cancer: protection and control of the cell surface","volume":"4","author":"Hollingsworth","year":"2004","journal-title":"Nat Rev Cancer"},{"issue":"24","key":"2025040309092685300_lvaf045-B48","doi-asserted-by":"publisher","first-page":"2712","DOI":"10.1101\/gad.247528.114","article-title":"HIRA orchestrates a dynamic chromatin landscape in senescence and is required for suppression of neoplasia","volume":"28","author":"Rai","year":"2014","journal-title":"Genes Dev"},{"issue":"1","key":"2025040309092685300_lvaf045-B49","doi-asserted-by":"publisher","first-page":"7711","DOI":"10.1038\/ncomms8711","article-title":"Ubinuclein-1 confers histone H3.3-specific-binding by the HIRA histone chaperone complex","volume":"6","author":"Daniel Ricketts","year":"2015","journal-title":"Nat Commun."},{"issue":"5","key":"2025040309092685300_lvaf045-B50","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1016\/j.cell.2010.01.003","article-title":"Distinct factors control histone variant H3.3 localization at specific genomic regions","volume":"140","author":"Goldberg","year":"2010","journal-title":"Cell"},{"issue":"4","key":"2025040309092685300_lvaf045-B51","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1016\/j.celrep.2013.03.026","article-title":"Placing the HIRA histone chaperone complex in the chromatin landscape","volume":"3","author":"Pchelintsev","year":"2013","journal-title":"Cell Rep"},{"issue":"23","key":"2025040309092685300_lvaf045-B52","doi-asserted-by":"publisher","first-page":"9239","DOI":"10.1074\/jbc.RA119.007480","article-title":"The HIRA histone chaperone complex subunit UBN1 harbors H3\/H4- and DNA-binding activity","volume":"294","author":"Ricketts","year":"2019","journal-title":"J Biol Chem"},{"issue":"7384","key":"2025040309092685300_lvaf045-B53","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1038\/nature10833","article-title":"Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma","volume":"482","author":"Schwartzentruber","year":"2012","journal-title":"Nature"},{"issue":"2","key":"2025040309092685300_lvaf045-B54","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1093\/hmg\/6.2.237","article-title":"Cloning and developmental expression analysis of chick Hira (Chira), a candidate gene for DiGeorge syndrome","volume":"6","author":"Roberts","year":"1997","journal-title":"Hum Mol Genet"}],"container-title":["European Journal of Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ejendo\/article-pdf\/192\/4\/398\/62848359\/lvaf045.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ejendo\/article-pdf\/192\/4\/398\/62848359\/lvaf045.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T09:57:59Z","timestamp":1743674279000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/192\/4\/398\/8104769"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,27]]},"references-count":54,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,3,27]]}},"URL":"https:\/\/doi.org\/10.1093\/ejendo\/lvaf045","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,4]]},"published":{"date-parts":[[2025,3,27]]}}}