{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T02:10:03Z","timestamp":1793326203960,"version":"4.5.0"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","award":["56569607"],"award-info":[{"award-number":["56569607"]}],"id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014382","name":"Ipsen","doi-asserted-by":"publisher","award":["GLB-SOP-006"],"award-info":[{"award-number":["GLB-SOP-006"]}],"id":[{"id":"10.13039\/501100014382","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Acromegaly is associated with multiple musculoskeletal complications that affect the quality of life and work ability. We aimed to examine the risk of osteoarthritis, musculoskeletal surgery (including joint replacement), osteoporosis, fractures, and analgesic consumption in Danish acromegaly patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>National, registry-based cohort study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>All validated incidents and prevalent cases of acromegaly in the period 1977-2021 (n = 844) were included and matched 1:100 with healthy controls. Outcomes were identified using diagnosis, surgical procedure, and medication codes and analyzed using Cox regression and Kaplan-Meier plots.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Patients were at significantly increased risk of osteoarthritis of the shoulder [hazard ratio (HR): 5.25 (3.05; 9.06)], hip [HR: 3.15 (2.57; 3.87)], and knee [HR: 2.25 (1.85; 2.72)], and medically treated osteoporosis [HR: 2.13 (1.64; 2.78)] even before acromegaly diagnosis. The risk of joint replacement surgery of the shoulder [HR: 4.60 (2.57; 8.25)], hip [HR: 3.32 (2.67; 4.12)], and knee [HR: 2.52 (1.89; 3.36)] was increased in acromegaly patients, as was the risk of being prescribed weak analgesics [HR: 1.22 (1.04; 1.44)] or opioids [HR: 1.58 (1.38; 1.82)]. Surgical complications [HR: 2.19 (1.59; 3.03)] and repeat hip surgery [HR: 3.64 (2.09; 6.34)] also exhibited increased risk in patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>In acromegaly, severe osteoarthritis involving multiple joints develops even before acromegaly diagnosis and continues to progress over time after acromegaly treatment. Furthermore, acromegaly imposes an increased risk of medically treated osteoporosis, musculoskeletal surgery\u2014particularly joint replacement surgery\u2014, surgical complications, and the necessity of analgesic medication. Our findings warrant further research into the management of musculoskeletal disease in acromegaly.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejendo\/lvaf047","type":"journal-article","created":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T10:43:36Z","timestamp":1741862616000},"page":"308-317","source":"Crossref","is-referenced-by-count":16,"title":["Musculoskeletal disease in acromegaly\u2014a population-based registry study"],"prefix":"10.1093","volume":"192","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1333-4387","authenticated-orcid":false,"given":"Christian","family":"Rosendal","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Aalborg University Hospital , 9000 Aalborg ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai Christiansen","family":"Arlien-S\u00f8borg","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Internal Medicine, Aarhus University Hospital , 8200 Aarhus ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eigil Husted","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Aalborg University Hospital , 9000 Aalborg ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus Larsen","family":"Feltoft","sequence":"additional","affiliation":[{"name":"Department of Medicine, Copenhagen University Hospital\u2014Herlev and Gentofte Hospital , 2730 Herlev ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c5se Krogh","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Endocrinology, Copenhagen University Hospital\u2014Rigshospitalet , 2100 Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne Skovsager","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Odense University Hospital , 5000 Odense ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens Otto Lunde","family":"J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Internal Medicine, Aarhus University Hospital , 8200 Aarhus ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakob","family":"Dal","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Aalborg University Hospital, Steno Diabetes Center North Jutland , 9260 Aalborg ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,3,13]]},"reference":[{"key":"2025032511124602600_lvaf047-B1","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1007\/s11154-024-09875-z","article-title":"The changing landscape of acromegaly\u2014an epidemiological perspective","volume":"25","author":"Rosendal","year":"2024","journal-title":"Rev Endocr Metab Disord."},{"issue":"1","key":"2025032511124602600_lvaf047-B2","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/J.ECL.2007.10.002","article-title":"Acromegaly","volume":"37","author":"Ben-Shlomo","year":"2008","journal-title":"Endocrinol Metab Clin North Am."},{"issue":"4","key":"2025032511124602600_lvaf047-B3","doi-asserted-by":"publisher","first-page":"E937","DOI":"10.1210\/CLINEM\/DGZ096","article-title":"A consensus on the diagnosis and treatment of acromegaly comorbidities: an update","volume":"105","author":"Giustina","year":"2020","journal-title":"J Clin Endocrinol Metab."},{"issue":"1","key":"2025032511124602600_lvaf047-B4","doi-asserted-by":"publisher","first-page":"37","DOI":"10.3897\/FOLMED.65.E68278","article-title":"Association between pain, arthropathy and health-related quality of life in patients suffering from acromegaly. 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