{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T01:42:00Z","timestamp":1791423720141,"version":"4.3.3"},"reference-count":59,"publisher":"Oxford University Press (OUP)","issue":"Supplement_2","license":[{"start":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:00:00Z","timestamp":1760659200000},"content-version":"vor","delay-in-days":16,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Endocrine science remains underrepresented in European Union research programs despite the fundamental role of hormone health in human wellbeing. Analysis of the CORDIS database reveals a persistent gap between the societal impact of endocrine disorders and their research prioritization. At the national funding level, endocrine societies report limited or little attention of national research funding toward endocrinology. The EndoCompass project\u2014a joint initiative between the European Society of Endocrinology and the European Society of Pediatric Endocrinology, aimed to identify and promote strategic research priorities in endocrine science to address critical hormone-related health challenges.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Research priorities were established through comprehensive analysis of the EU CORDIS database covering the Horizon 2020 framework period (2014-2020). Expert consultation in growth disorders was conducted to identify key research priorities, followed by broader stakeholder engagement, including society members and patient advocacy groups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Research priorities encompass genetic diagnosis of growth disorders; growth plate-targeted therapies; molecular mechanisms of Silver-Russell syndrome and imprinting disorders; hypothalamic dysfunction in Prader-Willi syndrome; and characterization of Noonan syndrome and tall stature conditions. Emphasis is placed on creating disease registries to facilitate outcome studies and developing precision therapeutics based on growth regulation pathways.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This component of the EndoCompass project provides an evidence-based roadmap for strategic research investment. This framework identifies crucial investigation areas into growth disorder pathophysiology, prevention, and treatment strategies, ultimately aimed at reducing the burden of these disorders on individuals and society. The findings support the broader EndoCompass objective of aligning research funding with areas of highest potential impact in endocrine health.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejendo\/lvaf070","type":"journal-article","created":{"date-parts":[[2025,4,12]],"date-time":"2025-04-12T16:52:08Z","timestamp":1744476728000},"page":"ii72-ii83","source":"Crossref","is-referenced-by-count":1,"title":["EndoCompass project: research roadmap for growth disorders"],"prefix":"10.1093","volume":"193","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4397-4126","authenticated-orcid":false,"given":"Evelien F","family":"Gevers","sequence":"first","affiliation":[{"name":"Centre for Endocrinology, William Harvey Research Institute, Barts and The London Medical School, Queen Mary University of London , London EC1M 6BQ ,","place":["United Kingdom"]},{"name":"Department of Paediatric Endocrinology, Royal London Children's Hospital, Barts Health NHS Trust , London E1 1FR ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita C","family":"Hokken-Koelega","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Erasmus University Medical Centre Rotterdam, Sophia Children's Hospital , 3015 CN Rotterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maithe","family":"Tauber","sequence":"additional","affiliation":[{"name":"Centre de R\u00e9f\u00e9rence Maladies Rares PRADORT (syndrome de Prader-Willi et autres Ob\u00e9sit\u00e9s Rares avec Troubles du comportement alimentaire), H\u00f4pital des Enfants, CHU Toulouse, Universit\u00e9 Toulouse III , 31300 Toulouse ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7988-3587","authenticated-orcid":false,"given":"Gerhard","family":"Binder","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology, University Children's 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,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Assumpta","family":"Caix\u00e0s","sequence":"additional","affiliation":[{"name":"Endocrinology and Nutrition Department, Parc Taul\u00ed Hospital Universitari, Institut d\u2019Investigaci\u00f3, Innovaci\u00f3 Parc Taul\u00ed (I3PT-CERCA), 08208 Sabadell ,","place":["Spain"]},{"name":"Medicine Department, Universitat Aut\u00f2noma de Barcelona , 08208 Sabadell ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin H","family":"Davies","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Southampton, Southampton SO16 6YD ,","place":["United Kingdom"]},{"name":"Regional Centre for Paediatric Endocrinology, Southampton Children's Hospital , Southampton SO16 6YD ,","place":["United 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