{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,10]],"date-time":"2025-05-10T04:02:28Z","timestamp":1746849748670,"version":"3.40.5"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T00:00:00Z","timestamp":1746748800000},"content-version":"vor","delay-in-days":9,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Although GH and IGF-1 have long been proposed to play a role in immune-modulation, the circulating immune cell phenotype in acromegaly (ACRO) is poorly understood.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>This observational, prospective, single-site clinical trial (NCT05069324) analyzed peripheral blood mononuclear cell (PBMC) subpopulations in ACRO, investigating the role of disease control, pharmacological treatments, and metabolic profile.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Sixty consecutive patients with ACRO (34 males, mean age 54.7 \u00b1 15) attending an outpatient visit between July 2020 and December 2024 were enrolled. Patients were compared with two populations: 40 healthy controls (CTRL) and 40 patients with type 2 diabetes (T2DM), with no significant differences in age or sex. An 8-week follow-up evaluation was performed and compared among patients according to the introduction or changes in their pharmacological treatment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Compared with CTRL, ACRO patients had lower total monocytes with a decreased percentage of classical and an increased proportion of non-classical subsets. There were fewer NK cells, with higher CD56dim and lower CD56bright subpopulations, and similar T and B lymphocytes. Compared with T2DM, ACRO showed lower total monocytes, with higher classical and lower non-classical subsets, as well as lower NK cells and B lymphocytes. In the short-term, treatment appeared unable to restore immune cell profile but partially affected the distributions of innate immune cells subpopulations.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This is the first evidence of a distinct immunological pattern in ACRO that is independent of glucose metabolism. The immune signature may contribute to the persistence of cardio-metabolic and oncological risk observed in ACRO, even when the disease is adequately controlled by medical treatment.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejendo\/lvaf085","type":"journal-article","created":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T08:13:36Z","timestamp":1746778416000},"page":"577-589","source":"Crossref","is-referenced-by-count":0,"title":["Circulating immune cell profile in patients with acromegaly: results from the PROMISE, a prospective clinical trial"],"prefix":"10.1093","volume":"192","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1066-0064","authenticated-orcid":false,"given":"Tiziana","family":"Feola","sequence":"first","affiliation":[{"name":"Department of Experimental Medicine, Sapienza University of Rome , Rome 00161 ,","place":["Italy"]},{"name":"Neuroendocrinology, Neuromed Institute, IRCCS , Pozzilli 86077 ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5242-1761","authenticated-orcid":false,"given":"Dario","family":"De Alcubierre","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, Sapienza University of Rome , Rome 00161 ,","place":["Italy"]},{"name":"Neuroendocrinology, Neuromed Institute, IRCCS , Pozzilli 86077 ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2899-9146","authenticated-orcid":false,"given":"Giulia","family":"Puliani","sequence":"additional","affiliation":[{"name":"Oncological Endocrinology Unit, IRCCS Regina Elena National Cancer Institute , Rome 00144 ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessia","family":"Cozzolino","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, Sapienza University of Rome , Rome 00161 ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Sciarra","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, Sapienza University of Rome , Rome 00161 ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ludovica","family":"Vincenzi","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, Sapienza University of Rome , Rome 00161 ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4301-6662","authenticated-orcid":false,"given":"Valeria","family":"Hasenmajer","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, Sapienza University of Rome , Rome 00161 ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9904-4462","authenticated-orcid":false,"given":"Valentina","family":"Sada","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, Sapienza University of Rome , Rome 00161 ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marialuisa","family":"Appetecchia","sequence":"additional","affiliation":[{"name":"Oncological Endocrinology Unit, IRCCS Regina Elena National Cancer Institute , Rome 00144 ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3614-6151","authenticated-orcid":false,"given":"Elisa","family":"Giannetta","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, Sapienza University of Rome , Rome 00161 ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2220-9783","authenticated-orcid":false,"given":"Emilia","family":"Sbardella","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, Sapienza University of Rome , Rome 00161 ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5916-8997","authenticated-orcid":false,"given":"Marie-Lise","family":"Jaffrain-Rea","sequence":"additional","affiliation":[{"name":"Neuroendocrinology, Neuromed Institute, IRCCS , Pozzilli 86077 ,","place":["Italy"]},{"name":"Department of Biotechnological and Applied Clinical Sciences, University of L\u2019Aquila , L\u2019Aquila 67100 ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0687-8135","authenticated-orcid":false,"given":"Mary Anna","family":"Venneri","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, Sapienza University of Rome , Rome 00161 ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9037-5417","authenticated-orcid":false,"given":"Andrea M","family":"Isidori","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, Sapienza University of Rome , Rome 00161 ,","place":["Italy"]},{"name":"Policlinico Umberto I, Centre for Rare Diseases (Endo-ERN Accredited) , Rome 00161 ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,5,9]]},"reference":[{"issue":"1","key":"2025050904133177500_lvaf085-B1","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1038\/s41572-019-0071-6","article-title":"Acromegaly","volume":"5","author":"Colao","year":"2019","journal-title":"Nat Rev Dis Primers"},{"issue":"4","key":"2025050904133177500_lvaf085-B2","doi-asserted-by":"publisher","first-page":"e937","DOI":"10.1210\/clinem\/dgz096","article-title":"A consensus on the diagnosis and treatment of acromegaly comorbidities: an update","volume":"105","author":"Giustina","year":"2020","journal-title":"J Clin Endocrinol Metab"},{"issue":"11","key":"2025050904133177500_lvaf085-B3","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1016\/S2213-8587(22)00244-3","article-title":"Acromegaly: pathogenesis, diagnosis, and management","volume":"10","author":"Fleseriu","year":"2022","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"11","key":"2025050904133177500_lvaf085-B4","doi-asserted-by":"publisher","first-page":"1813","DOI":"10.1002\/pmic.201400242","article-title":"Synergistic effect of DHT and IGF-1 hyperstimulation in human peripheral blood lymphocytes","volume":"15","author":"Imperlini","year":"2015","journal-title":"Proteomics"},{"issue":"11","key":"2025050904133177500_lvaf085-B5","doi-asserted-by":"publisher","first-page":"4611","DOI":"10.1210\/endo.137.11.8895324","article-title":"Direct stimulatory effect of insulin-like growth factor-I on monocyte and macrophage tumor necrosis factor-alpha production","volume":"137","author":"Renier","year":"1996","journal-title":"Endocrinology"},{"key":"2025050904133177500_lvaf085-B6","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1159\/000360571","article-title":"Interaction between insulin-like growth factor-1 and atherosclerosis and vascular aging","volume":"43","author":"Higashi","year":"2014","journal-title":"Front Horm Res"},{"issue":"2","key":"2025050904133177500_lvaf085-B7","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.celrep.2017.03.046","article-title":"IGF1 shapes macrophage activation in response to immunometabolic challenge","volume":"19","author":"Spadaro","year":"2017","journal-title":"Cell Rep"},{"issue":"1","key":"2025050904133177500_lvaf085-B8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/2050-7771-2-1","article-title":"Monocyte and macrophage differentiation: circulation inflammatory monocyte as biomarker for inflammatory diseases","volume":"2","author":"Yang","year":"2014","journal-title":"Biomark Res"},{"issue":"1","key":"2025050904133177500_lvaf085-B9","doi-asserted-by":"publisher","first-page":"e12883","DOI":"10.1111\/sji.12883","article-title":"Pattern of human monocyte subpopulations in health and disease","volume":"92","author":"Ozanska","year":"2020","journal-title":"Scand J Immunol"},{"key":"2025050904133177500_lvaf085-B10","doi-asserted-by":"publisher","first-page":"2035","DOI":"10.3389\/fimmu.2019.02035","article-title":"Human monocyte subsets and phenotypes in Major chronic inflammatory diseases","volume":"10","author":"Kapellos","year":"2019","journal-title":"Front Immunol"},{"issue":"2","key":"2025050904133177500_lvaf085-B11","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1002\/JLB.4RI0818-311R","article-title":"Monocyte heterogeneity and functions in cancer","volume":"106","author":"Olingy","year":"2019","journal-title":"J Leukoc Biol"},{"issue":"11","key":"2025050904133177500_lvaf085-B12","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1016\/S1471-4906(01)02060-9","article-title":"The biology of human natural killer-cell subsets","volume":"22","author":"Cooper","year":"2001","journal-title":"Trends Immunol"},{"issue":"14","key":"2025050904133177500_lvaf085-B13","doi-asserted-by":"publisher","first-page":"3592","DOI":"10.3390\/cancers15143592","article-title":"Circulating natural killer cells as prognostic value for non-small-cell lung cancer patients treated with immune checkpoint inhibitors: correlation with sarcopenia","volume":"15","author":"Tenuta","year":"2023","journal-title":"Cancers (Basel)"},{"issue":"2","key":"2025050904133177500_lvaf085-B14","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1530\/JME-17-0062","article-title":"IGF1 potentiates the pro-inflammatory response in human peripheral blood mononuclear cells via MAPK","volume":"59","author":"Wolters","year":"2017","journal-title":"J Mol Endocrinol"},{"key":"2025050904133177500_lvaf085-B15","doi-asserted-by":"publisher","first-page":"101391","DOI":"10.1016\/j.ghir.2021.101391","article-title":"The association between treatment and systemic inflammation in acromegaly","volume":"57-58","author":"Wolters","year":"2021","journal-title":"Growth Horm IGF Res"},{"issue":"4","key":"2025050904133177500_lvaf085-B16","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1210\/jcem-60-4-740","article-title":"Specific growth hormone receptors on human peripheral mononuclear cells: reexpression, identification, and characterization","volume":"60","author":"Kiess","year":"1985","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"2025050904133177500_lvaf085-B17","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.cyto.2007.11.007","article-title":"Prolactin and growth hormone induce differential cytokine and chemokine profile in murine peritoneal macrophages in vitro: involvement of p-38 MAP kinase, STAT3 and NF-kappaB","volume":"41","author":"Sodhi","year":"2008","journal-title":"Cytokine"},{"issue":"2","key":"2025050904133177500_lvaf085-B18","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1182\/blood.V58.2.337.337","article-title":"Growth hormone stimulation of normal and leukemic human T-lymphocyte proliferation in vitro","volume":"58","author":"Mercola","year":"1981","journal-title":"Blood"},{"issue":"5","key":"2025050904133177500_lvaf085-B19","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1016\/0006-2952(89)90222-0","article-title":"Growth hormone, lymphocytes and macrophages","volume":"38","author":"Kelley","year":"1989","journal-title":"Biochem Pharmacol"},{"issue":"11","key":"2025050904133177500_lvaf085-B20","doi-asserted-by":"publisher","first-page":"5383","DOI":"10.1210\/jcem.86.11.8009","article-title":"GH strongly affects serum concentrations of mannan-binding lectin: evidence for a new IGF-I independent immunomodulatory effect of GH","volume":"86","author":"Hansen","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"2025050904133177500_lvaf085-B21","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1159\/000126805","article-title":"Effect of elevated growth hormone concentrations on the phenotype and functions of human lymphocytes and natural killer cells","volume":"60","author":"Kotzmann","year":"1994","journal-title":"Neuroendocrinology"},{"issue":"2","key":"2025050904133177500_lvaf085-B22","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1007\/BF03343975","article-title":"Lymphocyte subset pattern in acromegaly","volume":"25","author":"Colao","year":"2002","journal-title":"J Endocrinol Invest"},{"issue":"12","key":"2025050904133177500_lvaf085-B23","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.1530\/EC-19-0430","article-title":"Persistent inflammation and endothelial dysfunction in patients with treated acromegaly","volume":"8","author":"Wolters","year":"2019","journal-title":"Endocr Connect"},{"issue":"6","key":"2025050904133177500_lvaf085-B24","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1530\/EJE-20-0497","article-title":"Metabolic complications in acromegaly after neurosurgery: a meta-analysis","volume":"183","author":"Cozzolino","year":"2020","journal-title":"Eur J Endocrinol"},{"issue":"6):","key":"2025050904133177500_lvaf085-B25","doi-asserted-by":"publisher","first-page":"2089","DOI":"10.1210\/jc.2017-02566","article-title":"Somatostatin analogs and glucose metabolism in acromegaly: a meta-analysis of prospective interventional studies","volume":"103","author":"Cozzolino","year":"2018","journal-title":"J Clin Endocrinol Metab"},{"issue":"7","key":"2025050904133177500_lvaf085-B26","doi-asserted-by":"publisher","first-page":"2892","DOI":"10.1210\/jc.2018-02281","article-title":"Pegvisomant improves glucose metabolism in acromegaly: a meta-analysis of prospective interventional studies","volume":"104","author":"Feola","year":"2019","journal-title":"J Clin Endocrinol Metab"},{"issue":"9","key":"2025050904133177500_lvaf085-B27","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1038\/s41574-018-0058-5","article-title":"A consensus statement on acromegaly therapeutic outcomes","volume":"14","author":"Melmed","year":"2018","journal-title":"Nat Rev Endocrinol"},{"issue":"11","key":"2025050904133177500_lvaf085-B28","doi-asserted-by":"publisher","first-page":"3933","DOI":"10.1210\/jc.2014-2700","article-title":"Acromegaly: an endocrine society clinical practice guideline","volume":"99","author":"Katznelson","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"issue":"649","key":"2025050904133177500_lvaf085-B29","doi-asserted-by":"publisher","first-page":"eabl8503","DOI":"10.1126\/scitranslmed.abl8503","article-title":"Sex-specific effects of daily tadalafil on diabetic heart kinetics in RECOGITO, a randomized, double-blind, placebo-controlled trial","volume":"14","author":"Pofi","year":"2022","journal-title":"Sci Transl Med"},{"issue":"3","key":"2025050904133177500_lvaf085-B30","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/S2213-8587(17)30398-4","article-title":"Effect of once-daily, modified-release hydrocortisone versus standard glucocorticoid therapy on metabolism and innate immunity in patients with adrenal insufficiency (DREAM): a single-blind, randomised controlled trial","volume":"6","author":"Isidori","year":"2018","journal-title":"Lancet Diabetes Endocrinol"},{"key":"2025050904133177500_lvaf085-B31","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.clinbiochem.2023.02.008","article-title":"The impact of different calibration matrices on the determination of insulin-like growth factor 1 by high-resolution-LC-MS in acromegalic and growth hormone deficient patients","volume":"114","author":"Simstich","year":"2023","journal-title":"Clin Biochem"},{"issue":"7","key":"2025050904133177500_lvaf085-B32","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man","volume":"28","author":"Matthews","year":"1985","journal-title":"Diabetologia"},{"issue":"16","key":"2025050904133177500_lvaf085-B33","doi-asserted-by":"publisher","first-page":"e74","DOI":"10.1182\/blood-2010-02-258558","article-title":"Nomenclature of monocytes and dendritic cells in blood","volume":"116","author":"Ziegler-Heitbrock","year":"2010","journal-title":"Blood"},{"issue":"5","key":"2025050904133177500_lvaf085-B34","doi-asserted-by":"publisher","first-page":"e2215","DOI":"10.1210\/clinem\/dgab038","article-title":"Impaired immune function in patients with chronic postsurgical hypoparathyroidism: results of the EMPATHY study","volume":"106","author":"Puliani","year":"2021","journal-title":"J Clin Endocrinol Metab"},{"key":"2025050904133177500_lvaf085-B35","doi-asserted-by":"publisher","first-page":"105462","DOI":"10.1016\/j.ebiom.2024.105462","article-title":"Circadian clock disruption impairs immune oscillation in chronic endogenous hypercortisolism: a multi-level analysis from a multicentre clinical trial","volume":"110","author":"Hasenmajer","year":"2024","journal-title":"EBioMedicine"},{"issue":"2","key":"2025050904133177500_lvaf085-B36","doi-asserted-by":"publisher","first-page":"E344","DOI":"10.1152\/ajpendo.00048.2003","article-title":"Expression of somatostatin, cortistatin, and somatostatin receptors in human monocytes, macrophages, and dendritic cells","volume":"285","author":"Dalm","year":"2003","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"4","key":"2025050904133177500_lvaf085-B37","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1530\/eje.0.1500565","article-title":"Differential expression of somatostatin receptor subtypes in human peripheral blood mononuclear cell subsets","volume":"150","author":"Lichtenauer-Kaligis","year":"2004","journal-title":"Eur J Endocrinol"},{"issue":"2","key":"2025050904133177500_lvaf085-B38","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/S0301-472X(01)00772-X","article-title":"Somatostatin is a selective chemoattractant for primitive (CD34(+)) hematopoietic progenitor cells","volume":"30","author":"Oomen","year":"2002","journal-title":"Exp Hematol"},{"issue":"1):","key":"2025050904133177500_lvaf085-B39","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1007\/s12020-022-03257-8","article-title":"Characterization of circulating immune cells and correlation with tie2\/angiopoietins level in well differentiated neuroendocrine gastroenteropancreatic tumors: a cross-sectional analysis","volume":"80","author":"Sesti","year":"2022","journal-title":"Endocrine"},{"issue":"6","key":"2025050904133177500_lvaf085-B40","doi-asserted-by":"publisher","first-page":"2334","DOI":"10.1210\/jc.2007-2780","article-title":"Lower visceral and subcutaneous but higher intermuscular adipose tissue depots in patients with growth hormone and insulin-like growth factor I excess due to acromegaly","volume":"93","author":"Freda","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"2025050904133177500_lvaf085-B41","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1530\/EJE-13-0523","article-title":"Inflammatory adipokines contribute to insulin resistance in active acromegaly and respond differently to different treatment modalities","volume":"170","author":"Olarescu","year":"2014","journal-title":"Eur J Endocrinol"},{"issue":"17","key":"2025050904133177500_lvaf085-B42","doi-asserted-by":"publisher","first-page":"3997","DOI":"10.3390\/jcm10173997","article-title":"Neutrophil-to-lymphocyte, platelet-to-lymphocyte ratios, and systemic immune-inflammation Index as potential biomarkers of chronic inflammation in patients with newly diagnosed acromegaly: a single-centre study","volume":"10","author":"Szydelko","year":"2021","journal-title":"J Clin Med"},{"issue":"6","key":"2025050904133177500_lvaf085-B43","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1177\/0960327115597313","article-title":"Evaluation of blood neutrophil to lymphocyte and platelet to lymphocyte ratios according to plasma glucose status and serum insulin-like growth factor 1 levels in patients with acromegaly","volume":"35","author":"Ucler","year":"2016","journal-title":"Hum Exp Toxicol"},{"issue":"10","key":"2025050904133177500_lvaf085-B44","doi-asserted-by":"publisher","first-page":"e3796","DOI":"10.1210\/clinem\/dgab238","article-title":"Serum inflammation-based scores in endocrine tumors","volume":"106","author":"Marques","year":"2021","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"2025050904133177500_lvaf085-B45","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1007\/s11102-020-01112-5","article-title":"Pre-operative serum inflammation-based scores in patients with pituitary adenomas","volume":"24","author":"Marques","year":"2021","journal-title":"Pituitary"},{"issue":"7","key":"2025050904133177500_lvaf085-B46","doi-asserted-by":"publisher","first-page":"1571","DOI":"10.1016\/j.celrep.2016.01.044","article-title":"Growth hormone receptor deficiency protects against age-related NLRP3 inflammasome activation and immune senescence","volume":"14","author":"Spadaro","year":"2016","journal-title":"Cell Rep"},{"issue":"1","key":"2025050904133177500_lvaf085-B47","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1186\/s12943-020-01238-x","article-title":"Natural killer cells in cancer biology and therapy","volume":"19","author":"Wu","year":"2020","journal-title":"Mol Cancer"},{"issue":"6","key":"2025050904133177500_lvaf085-B48","doi-asserted-by":"publisher","first-page":"2182","DOI":"10.1210\/jc.2017-02457","article-title":"Cancer incidence in patients with acromegaly: a cohort study and meta-analysis of the literature","volume":"103","author":"Dal","year":"2018","journal-title":"J Clin Endocrinol Metab"},{"issue":"9","key":"2025050904133177500_lvaf085-B49","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1530\/ERC-16-0553","article-title":"Acromegaly is associated with increased cancer risk: a survey in Italy","volume":"24","author":"Terzolo","year":"2017","journal-title":"Endocr Relat Cancer"},{"issue":"5","key":"2025050904133177500_lvaf085-B50","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.1210\/clinem\/dgae469","article-title":"Prospective, longitudinal study of cancer predictors and rates in a New York city cohort of 598 patients with acromegaly","volume":"110","author":"Freda","year":"2025","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"2025050904133177500_lvaf085-B51","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1007\/s11102-024-01403-1","article-title":"The spectrum of cardiac abnormalities in patients with acromegaly: results from a case-control cardiac magnetic resonance study","volume":"27","author":"De Alcubierre","year":"2024","journal-title":"Pituitary"},{"issue":"1","key":"2025050904133177500_lvaf085-B52","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1038\/s41568-023-00639-6","article-title":"The dynamic role of platelets in cancer progression and their therapeutic implications","volume":"24","author":"Li","year":"2024","journal-title":"Nat Rev Cancer"},{"issue":"1","key":"2025050904133177500_lvaf085-B53","doi-asserted-by":"publisher","first-page":"25","DOI":"10.3390\/jcm12010025","article-title":"Resistance to somatostatin analogs in Italian acromegaly patients: the MISS study","volume":"12","author":"Berton","year":"2022","journal-title":"J Clin Med"},{"issue":"2","key":"2025050904133177500_lvaf085-B54","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1210\/er.2010-0002","article-title":"Resistance to somatostatin analogs in acromegaly","volume":"32","author":"Colao","year":"2011","journal-title":"Endocr Rev"}],"container-title":["European Journal of Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ejendo\/article-pdf\/192\/5\/577\/63133090\/lvaf085.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ejendo\/article-pdf\/192\/5\/577\/63133090\/lvaf085.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T08:13:37Z","timestamp":1746778417000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/192\/5\/577\/8127656"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,30]]},"references-count":54,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,4,30]]}},"URL":"https:\/\/doi.org\/10.1093\/ejendo\/lvaf085","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,5]]},"published":{"date-parts":[[2025,4,30]]}}}