{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T04:05:04Z","timestamp":1747973104953,"version":"3.41.0"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T00:00:00Z","timestamp":1747872000000},"content-version":"vor","delay-in-days":22,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016061","name":"De Drie Lichten","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016061","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014098","name":"Ren\u00e9 Vogels Stichting","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014098","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Stichting Scholten-Cordes"},{"name":"Hendrik Muller's Vaderlandsch Fonds"},{"name":"Strategic Network Development Grant"},{"name":"University Medical Center Utrecht"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>The objective of this study was to assess the prevalence of elevated insulin-like growth factor (IGF)-1 in children with suprasellar low-grade glioma (LGG) and explore the course of IGF-1 over time and its association with anthropometrics, hypothalamic syndrome, tumour characteristics, and tumour behaviour.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>This retrospective study included children from the Netherlands and the United Kingdom diagnosed with a suprasellar LGG under the age of 18 between 2003 and 2023, with a minimum 1-year follow-up. Elevated IGF-1 was defined as IGF-1 standard deviation score (SDS) &amp;gt;+2.0 for age and biological sex, without growth hormone use.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We included 235 patients with a median age at brain tumour diagnosis of 3.8 years (IQR 1.7-7.1). Elevated IGF-1 was observed in 73 patients (31.1%) at any time point. At tumour diagnosis, 15.2% of the 138 children tested showed elevated IGF-1. Elevated IGF-1 was associated with younger age at tumour diagnosis (P = .004), neurofibromatosis type 1 (NF1; P = .028), and diencephalic syndrome (P = .047). In 55 of the 73 patients with elevated IGF-1 (75.3%), IGF-1 normalized spontaneously over time. Final height SDS corrected for target height SDS was not associated with having had an elevated IGF-1 (P = .113). No difference was found in the number of tumour progressions.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Increased IGF-1 concentrations are commonly observed in children with suprasellar LGG, especially in younger children, those with an NF1 mutation, or during underweight. Elevation of IGF-1 can resolve over time, and the absence of an effect on final height or on tumour progressions seems reassuring.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejendo\/lvaf095","type":"journal-article","created":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T05:37:22Z","timestamp":1747892242000},"page":"641-650","source":"Crossref","is-referenced-by-count":0,"title":["Increased insulin-like growth factor-1 concentrations in paediatric suprasellar low-grade glioma: an international multicentre study"],"prefix":"10.1093","volume":"192","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1957-6750","authenticated-orcid":false,"given":"Ichelle M A A","family":"van Roessel","sequence":"first","affiliation":[{"name":"Department of Pediatric Neuro-oncology, Princess M\u00e1xima Center for Pediatric Onology , Heidelberglaan 25, Utrecht 3584 CS ,","place":["The Netherlands"]},{"name":"Department of Pediatric Endocrinology, Wilhelmina Children\u2019s Hospital, University Medical Center , Lundlaan 6, Utrecht 3584 EA ,","place":["The Netherlands"]},{"name":"Department of Paediatric Endocrinology, Great Ormond Street Hospital for Children NHS Foundation Trust , London WC1N 3BH ,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0229-1123","authenticated-orcid":false,"given":"Boudewijn","family":"Bakker","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology, Wilhelmina Children\u2019s Hospital, University Medical Center , Lundlaan 6, Utrecht 3584 EA ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1089-8091","authenticated-orcid":false,"given":"Antoinette Y N","family":"Schouten-van Meeteren","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neuro-oncology, Princess M\u00e1xima Center for Pediatric Onology , Heidelberglaan 25, Utrecht 3584 CS ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9101-507X","authenticated-orcid":false,"given":"Wim J E","family":"Tissing","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neuro-oncology, Princess M\u00e1xima Center for Pediatric Onology , Heidelberglaan 25, Utrecht 3584 CS ,","place":["The Netherlands"]},{"name":"Department of Pediatric Oncology and Hematology, University of Groningen, University Medical Center Groningen , Hanzeplein 1, Groningen 9713 GZ ,","place":["Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6198-0397","authenticated-orcid":false,"given":"Hoong-Wei","family":"Gan","sequence":"additional","affiliation":[{"name":"Department of Paediatric Endocrinology, Great Ormond Street Hospital for Children NHS Foundation Trust , London WC1N 3BH ,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6773-6931","authenticated-orcid":false,"given":"Hanneke M","family":"van Santen","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neuro-oncology, Princess M\u00e1xima Center for Pediatric Onology , Heidelberglaan 25, Utrecht 3584 CS ,","place":["The Netherlands"]},{"name":"Department of Pediatric Endocrinology, Wilhelmina Children\u2019s Hospital, University Medical Center , Lundlaan 6, Utrecht 3584 EA ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,5,22]]},"reference":[{"issue":"1","key":"2025052201371944800_lvaf095-B1","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/s40478-020-00902-z","article-title":"Pediatric low-grade glioma in the era of molecular diagnostics","volume":"8","author":"Ryall","year":"2020","journal-title":"Acta Neuropathol 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