{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T06:03:12Z","timestamp":1778220192842,"version":"3.51.4"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T00:00:00Z","timestamp":1749600000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["32473B162608"],"award-info":[{"award-number":["32473B162608"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Clinical Research grant from the Swiss Academy"},{"name":"Medical Sciences and G.& J. Bangerter-Rhyner Foundation"},{"name":"Hemmi-Foundation"},{"DOI":"10.13039\/100008375","name":"University of Basel","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008375","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023287","name":"Swiss Society for Endocrinology and Diabetology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100023287","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018956","name":"NIHR Cambridge Biomedical Research Centre","doi-asserted-by":"publisher","award":["NIHR203312"],"award-info":[{"award-number":["NIHR203312"]}],"id":[{"id":"10.13039\/501100018956","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018956","name":"NIHR Cambridge Biomedical Research Centre","doi-asserted-by":"publisher","award":["FAPEMIG-APQ-01521-21"],"award-info":[{"award-number":["FAPEMIG-APQ-01521-21"]}],"id":[{"id":"10.13039\/501100018956","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Minas Gerais Research Support Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Arginine vasopressin (AVP), synthesized in the hypothalamus and stored in the posterior pituitary, regulates osmotic balance and stress responses. During stress, AVP enhances corticotropin-releasing hormone-stimulated adrenocorticotropic hormone (ACTH) secretion, with cortisol and AVP providing negative feedback regulation. Disruption in AVP production might impair this feedback, leading to sustained cortisol elevations. The current analysis aims to investigate the effect of hypertonic saline (osmotic stress) and arginine infusion (non-osmotic stress) on the hypothalamic-pituitary-adrenal (HPA) axis response between patients with AVP-Deficiency and primary polydipsia (PP).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>Secondary sub-analysis of a prospective diagnostic study conducted at seven tertiary centers that utilized hypertonic saline and arginine infusion for diagnostic evaluation of patients with hypotonic polyuria-polydipsia syndrome.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>ACTH and cortisol levels were measured at baseline and the expected peak for both stimulation tests and groups. A pooled linear mixed-effects model (without stimulation type as a variable) was used to compare hormone responses between groups, followed by stimulation test-specific linear regression models to assess differences between both tests.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Twenty patients with AVP-Deficiency and 10 patients with PP were included. In the pooled analysis, patients with AVP-Deficiency showed a significantly greater increase in plasma ACTH [7.0\u2005ng\/L (95% CI, 0.8-13.3), P = .04] and plasma cortisol [106\u2005nmol\/L (95% CI, 24-188), P = .02] compared to patients with PP. Upon hypertonic saline, the changes in plasma ACTH [0.3\u2005ng\/L (95% CI, \u221210.0 to 11.0)] and plasma cortisol [78\u2005nmol\/L (95% CI, \u221232 to 188)] were similar. However, upon arginine infusion, plasma ACTH [9.2\u2005ng\/L (95% CI, 1.8-17)] and plasma cortisol [141\u2005nmol\/L (95% CI, 40-242)] increases were significantly greater in patients with AVP-Deficiency.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>An altered ACTH and cortisol response pattern to stress in patients with AVP-Deficiency was observed, indicating impaired regulation of the HPA axis. This alteration was primarily driven by differences observed for non-osmotic stress.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejendo\/lvaf119","type":"journal-article","created":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T18:20:21Z","timestamp":1749666021000},"page":"1-9","source":"Crossref","is-referenced-by-count":4,"title":["Disrupted ACTH and cortisol response to osmotic and non-osmotic stress in patients with arginine vasopressin deficiency"],"prefix":"10.1093","volume":"193","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-2294-9262","authenticated-orcid":false,"given":"Andi","family":"Nikaj","sequence":"first","affiliation":[{"name":"Departments of Endocrinology, Diabetology and Metabolism University Hospital Basel , 4031 Basel ,","place":["Switzerland"]},{"name":"Department of Clinical Research, University Hospital Basel, University of Basel , 4031 Basel ,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5442-7304","authenticated-orcid":false,"given":"Cihan","family":"Atila","sequence":"additional","affiliation":[{"name":"Departments of Endocrinology, Diabetology and Metabolism University Hospital Basel , 4031 Basel ,","place":["Switzerland"]},{"name":"Department of Clinical Research, University Hospital Basel, University of Basel , 4031 Basel ,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6741-2689","authenticated-orcid":false,"given":"Irina","family":"Chifu","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetes, Department of Internal Medicine I, University Hospital, University of Wuerzburg , 97080 Wuerzburg ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0556-7650","authenticated-orcid":false,"given":"Emanuele","family":"Ferrante","sequence":"additional","affiliation":[{"name":"Endocrinology Unit, Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico , 20122 Milan ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zoran","family":"Erlic","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetology, and Clinical Nutrition, University Hospital Zurich (USZ) and University of Zurich (UZH) , 8091 Z\u00fcrich ,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana B","family":"Drummond","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Medical School of the Federal University of Minas Gerais , 30130-100 Belo Horizonte, MG ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5642-0563","authenticated-orcid":false,"given":"Rita","family":"Indirli","sequence":"additional","affiliation":[{"name":"Endocrinology Unit, Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico , 20122 Milan ,","place":["Italy"]},{"name":"Department of Clinical Sciences and Community Health, University of Milan , 20122 Milan ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roosmarijn","family":"Drexhage","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Section of Endocrinology, Erasmus Medical Center , 3015 Rotterdam ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew S","family":"Powlson","sequence":"additional","affiliation":[{"name":"Wellcome-MRC Institute of Metabolic Science, University of Cambridge & Addenbrooke's Hospital , Cambridge Biomedical Campus, CB2 0QQ Cambridge ,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5745-6832","authenticated-orcid":false,"given":"Mark","family":"Gurnell","sequence":"additional","affiliation":[{"name":"Wellcome-MRC Institute of Metabolic Science, University of Cambridge & Addenbrooke's Hospital , Cambridge Biomedical Campus, CB2 0QQ Cambridge ,","place":["United Kingdom"]},{"name":"Cambridge NIHR Biomedical Research Centre, Cambridge University Hospitals , CB2 0QQ Cambridge ,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriz S","family":"Soares","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Medical School of the Federal University of Minas Gerais , 30130-100 Belo Horizonte, MG ,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0679-6209","authenticated-orcid":false,"given":"Johannes","family":"Hofland","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Section of Endocrinology, Erasmus Medical Center , 3015 Rotterdam ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7826-3984","authenticated-orcid":false,"given":"Felix","family":"Beuschlein","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetology, and Clinical Nutrition, University Hospital Zurich (USZ) and University of Zurich (UZH) , 8091 Z\u00fcrich ,","place":["Switzerland"]},{"name":"Medizinische Klinik und Poliklinik IV, Klinikum der Universit\u00e4t, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen , 81377 Munich ,","place":["Germany"]},{"name":"The LOOP Zurich\u2014Medical Research Center , 8044 Zurich ,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6170-6398","authenticated-orcid":false,"given":"Martin","family":"Fassnacht","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetes, Department of Internal Medicine I, University Hospital, University of Wuerzburg , 97080 Wuerzburg ,","place":["Germany"]},{"name":"Central Laboratory, University Hospital Wuerzburg , 97080 Wuerzburg ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8305-2700","authenticated-orcid":false,"given":"Bettina","family":"Winzeler","sequence":"additional","affiliation":[{"name":"Departments of Endocrinology, Diabetology and Metabolism University Hospital Basel , 4031 Basel ,","place":["Switzerland"]},{"name":"Department of Clinical Research, University Hospital Basel, University of Basel , 4031 Basel ,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Refardt","sequence":"additional","affiliation":[{"name":"Departments of Endocrinology, Diabetology and Metabolism University Hospital Basel , 4031 Basel ,","place":["Switzerland"]},{"name":"Department of Clinical Research, University Hospital Basel, University of Basel , 4031 Basel ,","place":["Switzerland"]},{"name":"Department of Internal Medicine, Section of Endocrinology, Erasmus Medical Center , 3015 Rotterdam ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6336-0965","authenticated-orcid":false,"given":"Mirjam","family":"Christ-Crain","sequence":"additional","affiliation":[{"name":"Departments of Endocrinology, Diabetology and Metabolism University Hospital Basel , 4031 Basel ,","place":["Switzerland"]},{"name":"Department of Clinical Research, University Hospital Basel, University of Basel , 4031 Basel ,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,6,11]]},"reference":[{"issue":"4","key":"2025070706063962000_lvaf119-B1","doi-asserted-by":"publisher","first-page":"1701","DOI":"10.1002\/cphy.c150053","article-title":"Magnocellular neurons and posterior pituitary function","volume":"6","author":"Brown","year":"2016","journal-title":"Compr Physiol"},{"issue":"6","key":"2025070706063962000_lvaf119-B2","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1159\/000124040","article-title":"Differential responses to osmotic stress of vasopressin-neurophysin mRNA in hypothalamic nuclei","volume":"39","author":"Burbach","year":"1984","journal-title":"Neuroendocrinology"},{"issue":"6","key":"2025070706063962000_lvaf119-B3","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1002\/ana.21783","article-title":"Copeptin: a novel, independent prognostic marker in patients with ischemic stroke","volume":"66","author":"Katan","year":"2009","journal-title":"Ann Neurol"},{"key":"2025070706063962000_lvaf119-B4","doi-asserted-by":"publisher","first-page":"w13101","DOI":"10.4414\/smw.2010.13101","article-title":"The stress hormone copeptin: a new prognostic biomarker in acute illness","volume":"140","author":"Katan","year":"2010","journal-title":"Swiss Med Wkly"},{"issue":"1","key":"2025070706063962000_lvaf119-B5","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.jacc.2009.01.076","article-title":"Incremental value of copeptin for rapid rule out of acute myocardial infarction","volume":"54","author":"Reichlin","year":"2009","journal-title":"J Am Coll Cardiol"},{"issue":"10","key":"2025070706063962000_lvaf119-B6","doi-asserted-by":"publisher","first-page":"3973","DOI":"10.1210\/jc.2007-0232","article-title":"Changes in plasma copeptin, the c-terminal portion of arginine vasopressin during water deprivation and excess in healthy subjects","volume":"92","author":"Szinnai","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"issue":"1-2","key":"2025070706063962000_lvaf119-B7","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/s0167-0115(00)00196-8","article-title":"Vasopressinergic regulation of the hypothalamic-pituitary-adrenal axis: implications for stress adaptation","volume":"96","author":"Aguilera","year":"2000","journal-title":"Regul Pept"},{"issue":"2","key":"2025070706063962000_lvaf119-B8","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1006\/frne.1993.1004","article-title":"Vasopressinergic control of pituitary adrenocorticotropin secretion comes of age","volume":"14","author":"Antoni","year":"1993","journal-title":"Front Neuroendocrinol"},{"issue":"5881","key":"2025070706063962000_lvaf119-B9","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1038\/299355a0","article-title":"Corticotropin releasing activity of the new CRF is potentiated several times by vasopressin","volume":"299","author":"Gillies","year":"1982","journal-title":"Nature"},{"issue":"5932","key":"2025070706063962000_lvaf119-B10","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1038\/305325a0","article-title":"Modulation of stress-induced ACTH release by corticotropin-releasing factor, catecholamines and vasopressin","volume":"305","author":"Rivier","year":"1983","journal-title":"Nature"},{"issue":"4","key":"2025070706063962000_lvaf119-B11","doi-asserted-by":"publisher","first-page":"383","DOI":"10.31887\/DCNS.2006.8.4\/ssmith","article-title":"The role of the hypothalamic-pituitary-adrenal axis in neuroendocrine responses to stress","volume":"8","author":"Smith","year":"2006","journal-title":"Dialogues Clin Neurosci"},{"issue":"23","key":"2025070706063962000_lvaf119-B12","doi-asserted-by":"publisher","first-page":"7725","DOI":"10.1523\/JNEUROSCI.16-23-07725.1996","article-title":"Release of vasopressin within the rat paraventricular nucleus in response to emotional stress: a novel mechanism of regulating adrenocorticotropic hormone secretion?","volume":"16","author":"Wotjak","year":"1996","journal-title":"J Neurosci"},{"issue":"1","key":"2025070706063962000_lvaf119-B13","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1002\/da.20220","article-title":"HPA axis activity in patients with panic disorder: review and synthesis of four studies","volume":"24","author":"Abelson","year":"2007","journal-title":"Depress Anxiety"},{"issue":"1","key":"2025070706063962000_lvaf119-B14","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1038\/s41572-019-0103-2","article-title":"Diabetes insipidus","volume":"5","author":"Christ-Crain","year":"2019","journal-title":"Nat Rev Dis Primers"},{"issue":"10","key":"2025070706063962000_lvaf119-B15","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1016\/S2213-8587(22)00219-4","article-title":"Central diabetes insipidus from a patient's perspective: management, psychological co-morbidities, and renaming of the condition: results from an international web-based survey","volume":"10","author":"Atila","year":"2022","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"12","key":"2025070706063962000_lvaf119-B16","doi-asserted-by":"publisher","first-page":"5749","DOI":"10.1210\/jcem.86.12.8073","article-title":"Increases in plasma ACTH and cortisol after hypertonic saline infusion in patients with central diabetes insipidus","volume":"86","author":"Itagaki","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"issue":"7","key":"2025070706063962000_lvaf119-B17","doi-asserted-by":"publisher","first-page":"dgaa157","DOI":"10.1210\/clinem\/dgaa157","article-title":"Effect of arginine on the hypothalamic-pituitary-adrenal axis in individuals with and without vasopressin deficiency","volume":"105","author":"Bologna","year":"2020","journal-title":"J Clin Endocrinol Metab"},{"issue":"20","key":"2025070706063962000_lvaf119-B18","doi-asserted-by":"publisher","first-page":"1877","DOI":"10.1056\/NEJMoa2306263","article-title":"Arginine or hypertonic saline-stimulated copeptin to diagnose AVP deficiency","volume":"389","author":"Refardt","year":"2023","journal-title":"N Engl J Med"},{"issue":"6","key":"2025070706063962000_lvaf119-B19","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1111\/cen.14835","article-title":"Hypothalamic-pituitary-adrenal axis activity in patients with primary polydipsia compared to healthy controls","volume":"99","author":"Sailer","year":"2023","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"1","key":"2025070706063962000_lvaf119-B20","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1210\/endo-125-1-554","article-title":"Characterization of anterior pituitary target cells for arginine vasopressin: including cells that store adrenocorticotropin, thyrotropin-beta, and both hormones","volume":"125","author":"Childs","year":"1989","journal-title":"Endocrinology"},{"issue":"5","key":"2025070706063962000_lvaf119-B21","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1113\/jphysiol.2015.284471","article-title":"Large conductance Ca(2)(+)-activated K(+) (BK) channels promote secretagogue-induced transition from spiking to bursting in murine anterior pituitary corticotrophs","volume":"593","author":"Duncan","year":"2015","journal-title":"J Physiol"},{"issue":"8","key":"2025070706063962000_lvaf119-B22","doi-asserted-by":"publisher","first-page":"3108","DOI":"10.1210\/en.2016-1115","article-title":"Glucocorticoids inhibit CRH\/AVP-evoked bursting activity of male murine anterior pituitary corticotrophs","volume":"157","author":"Duncan","year":"2016","journal-title":"Endocrinology"},{"issue":"3","key":"2025070706063962000_lvaf119-B23","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1007\/s12020-017-1366-6","article-title":"Copeptin as a marker of an altered CRH axis in pituitary disease","volume":"57","author":"Lewandowski","year":"2017","journal-title":"Endocrine"},{"issue":"6","key":"2025070706063962000_lvaf119-B24","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1210\/jcem-66-6-1132","article-title":"Role of endogenous arginine vasopressin in potentiating corticotropin-releasing hormone-stimulated corticotropin secretion in man","volume":"66","author":"Watabe","year":"1988","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"2025070706063962000_lvaf119-B25","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1530\/eje.0.1300121","article-title":"Enhanced adrenocorticotrophic hormone and cortisol responses to corticotrophin-releasing hormone in central idiopathic diabetes insipidus","volume":"130","author":"Mazza","year":"1994","journal-title":"Eur J Endocrinol"},{"issue":"11","key":"2025070706063962000_lvaf119-B26","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1007\/BF03344064","article-title":"Hypothalamus-pituitary-adrenal axis in central diabetes insipidus: ACTH and cortisol responsiveness to CRH administration","volume":"25","author":"Pivonello","year":"2002","journal-title":"J Endocrinol Invest"},{"issue":"1","key":"2025070706063962000_lvaf119-B27","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1111\/j.1442-200X.2007.02320.x","article-title":"Corticotropin and cortisol response to maximal exercise testing in central diabetes insipidus","volume":"49","author":"Bas","year":"2007","journal-title":"Pediatr Int"},{"issue":"6","key":"2025070706063962000_lvaf119-B28","doi-asserted-by":"publisher","first-page":"1186","DOI":"10.1210\/jcem-67-6-1186","article-title":"Arginine stimulates growth hormone secretion by suppressing endogenous somatostatin secretion","volume":"67","author":"Alba-Roth","year":"1988","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"2025070706063962000_lvaf119-B29","doi-asserted-by":"publisher","first-page":"1546","DOI":"10.1210\/endo-114-5-1546","article-title":"Central nervous system regulation of adrenocorticotropin secretion: role of somatostatins","volume":"114","author":"Brown","year":"1984","journal-title":"Endocrinology"},{"issue":"4","key":"2025070706063962000_lvaf119-B30","doi-asserted-by":"publisher","first-page":"104093","DOI":"10.1016\/j.lpm.2021.104093","article-title":"Diabetes insipidus","volume":"50","author":"Christ-Crain","year":"2021","journal-title":"Presse Med"},{"issue":"7","key":"2025070706063962000_lvaf119-B31","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1016\/S2213-8587(23)00120-1","article-title":"Oxytocin in response to MDMA provocation test in patients with arginine vasopressin deficiency (central diabetes insipidus): a single-centre, case-control study with nested, randomised, double-blind, placebo-controlled crossover trial","volume":"11","author":"Atila","year":"2023","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"8","key":"2025070706063962000_lvaf119-B32","doi-asserted-by":"publisher","first-page":"3181","DOI":"10.1210\/jc.2018-02608","article-title":"Low plasma oxytocin levels and increased psychopathology in hypopituitary men with diabetes insipidus","volume":"104","author":"Aulinas","year":"2019","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"2025070706063962000_lvaf119-B33","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1007\/s12020-017-1332-3","article-title":"Hypopituitarism is associated with lower oxytocin concentrations and reduced empathic ability","volume":"57","author":"Daughters","year":"2017","journal-title":"Endocrine"},{"key":"2025070706063962000_lvaf119-B34","doi-asserted-by":"publisher","first-page":"dgaf201","DOI":"10.1210\/clinem\/dgaf201","article-title":"Melatonin as a possible stimulus to unmask an oxytocin deficient state in hypopituitarism and hypothalamic damage","author":"Asla","year":"2025","journal-title":"J Clin Endocrinol Metab"},{"issue":"12","key":"2025070706063962000_lvaf119-B35","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.1016\/s0006-3223(03)00465-7","article-title":"Social support and oxytocin interact to suppress cortisol and subjective responses to psychosocial stress","volume":"54","author":"Heinrichs","year":"2003","journal-title":"Biol Psychiatry"},{"issue":"9","key":"2025070706063962000_lvaf119-B36","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1016\/j.biopsych.2008.10.011","article-title":"Intranasal oxytocin increases positive communication and reduces cortisol levels during couple conflict","volume":"65","author":"Ditzen","year":"2009","journal-title":"Biol Psychiatry"},{"key":"2025070706063962000_lvaf119-B37","doi-asserted-by":"publisher","first-page":"43","DOI":"10.3389\/fnagi.2019.00043","article-title":"High cortisol and the risk of dementia and Alzheimer's disease: a review of the literature","volume":"11","author":"Ouanes","year":"2019","journal-title":"Front Aging Neurosci"}],"container-title":["European Journal of Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ejendo\/advance-article-pdf\/doi\/10.1093\/ejendo\/lvaf119\/63472705\/lvaf119.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ejendo\/article-pdf\/193\/1\/1\/63472705\/lvaf119.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ejendo\/article-pdf\/193\/1\/1\/63472705\/lvaf119.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T10:06:47Z","timestamp":1751882807000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/193\/1\/1\/8160588"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,11]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,6,30]]}},"URL":"https:\/\/doi.org\/10.1093\/ejendo\/lvaf119","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,7]]},"published":{"date-parts":[[2025,6,11]]}}}