{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:42:06Z","timestamp":1790804526558,"version":"4.1.0"},"reference-count":64,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T00:00:00Z","timestamp":1751846400000},"content-version":"vor","delay-in-days":7,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>This study aimed to investigate the long-term growth responses to recombinant human growth hormone (rhGH) in children with idiopathic short stature (ISS), decreased insulin-like growth factor I (IGF-1) levels, and a normal stimulated GH peak, after assessing their growth hormone (GH) sensitivity using the IGF-1 generation test (IGFGT)<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>This was a retrospective descriptive case series.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>One hundred and twenty-nine children with height &amp;lt; -2.5 standard deviation score (SDS), IGF-1 &amp;lt; \u22122.0 SDS on 2 occasions, and peak GH &amp;gt;10\u2005\u00b5g\/L underwent an IGFGT to be categorized into normal (neurosecretory dysfunction), intermediate, or low GH sensitivity. The first group was treated with an rhGH substitution dose (0.025\u20130.035\u2005mg\/kg) and the others with a higher dose (0.035\u20130.050\u2005mg\/kg). Patients were followed for at least 1 year, with 58 patients reaching near-adult height (NAH). Prepubertal and pubertal patients were analysed separately.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>During the first year of treatment in prepubertal patients, height increased by 0.8 \u00b1 0.4 SDS, height velocity by 4.0 \u00b1 2.1\u2005cm\/year, and predicted adult height (PAH) by 0.6 \u00b1 0.7 SDS. At NAH, average height was \u22121.0 \u00b1 1.0 SDS, which is 2.1 \u00b1 0.8 SDS higher than height at start, 1.5 \u00b1 0.8 SDS higher than PAH at start, and 0.3 \u00b1 0.9 SDS below target height. No group differences were observed. Using the rhGH treatment prediction models from the KIGS database, patients performed better than expected for ISS and similar to patients with idiopathic isolated GH deficiency.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Children with ISS, decreased IGF-1 levels, and a normal stimulated GH peak show a good response to rhGH treatment. The IGFGT is a useful tool for selecting this subgroup from ISS patients and optimizing rhGH dose.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ejendo\/lvaf137","type":"journal-article","created":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T05:03:37Z","timestamp":1751864617000},"page":"156-166","source":"Crossref","is-referenced-by-count":4,"title":["Growth hormone treatment adjusted for growth hormone sensitivity in idiopathic short stature"],"prefix":"10.1093","volume":"193","author":[{"given":"Anne R","family":"Kruijsen","sequence":"first","affiliation":[{"name":"Division of Paediatric Endocrinology, Department of Paediatrics, Willem-Alexander Children's Hospital, Leiden University Medical Centre , PO Box 9600, Leiden 2300RC ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan M","family":"Wit","sequence":"additional","affiliation":[{"name":"Division of Paediatric Endocrinology, Department of Paediatrics, Willem-Alexander Children's Hospital, Leiden University Medical Centre , PO Box 9600, Leiden 2300RC ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten","family":"de Groote","sequence":"additional","affiliation":[{"name":"Division of Paediatric Endocrinology, Department of Paediatrics, Willem-Alexander Children's Hospital, Leiden University Medical Centre , PO Box 9600, Leiden 2300RC ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren D","family":"Punt","sequence":"additional","affiliation":[{"name":"Division of Paediatric Endocrinology, Department of Paediatrics, Willem-Alexander Children's Hospital, Leiden University Medical Centre , PO Box 9600, Leiden 2300RC ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A S Paul","family":"van Trotsenburg","sequence":"additional","affiliation":[{"name":"Department of Paediatric Endocrinology, Emma Children's Hospital, Amsterdam University Medical Centres, University of Amsterdam , Amsterdam 1105AZ ,","place":["The Netherlands"]},{"name":"Department of Endocrinology and Metabolism, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam University Medical Centers, University of Amsterdam , Amsterdam 1105AZ ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karijn J","family":"Pijnenburg-Kleizen","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Canisius Wilhelmina Hospital , Nijmegen 6532SZ ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2665-8738","authenticated-orcid":false,"given":"Gianni","family":"Bocca","sequence":"additional","affiliation":[{"name":"Division of Paediatric Endocrinology, Department of Paediatrics, Beatrix Children's Hospital, University Medical Centre Groningen , Groningen 9713GZ ,","place":["The 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Children's Hospital, Radboud University Medical Centre , Nijmegen 6525GA ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6408-1717","authenticated-orcid":false,"given":"Dani\u00eblle C M","family":"van der Kaay","sequence":"additional","affiliation":[{"name":"Division of Paediatric Endocrinology, Department of Paediatrics, Erasmus University Medical Centre, Sophia Children's Hospital , Rotterdam 3015GD ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Schott","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Zuyderland Hospital , Heerlen 6419PC ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera","family":"van Tellingen","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Catharina Hospital , Eindhoven 5623ED ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgar G A H","family":"van Mil","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Jeroen Bosch Hospital , \u2018s-Hertogenbosch 5223GZ ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josine C","family":"van der Heyden","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Franciscus Gasthuis , Rotterdam 3045PM ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annelies E","family":"Brandsma","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Maasstad Hospital , Rotterdam 3079DZ ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne","family":"Hendriks","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics, Leiden University Medical Centre , Leiden 2300RC ,","place":["The 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