{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:18:37Z","timestamp":1787008717802,"version":"build-2736575974"},"reference-count":57,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:00:00Z","timestamp":1756425600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The indication for laparoscopic partial adrenalectomy (LPA) in patients with primary aldosteronism due to aldosterone-producing adenoma (APA) remains controversial. This study aimed to determine the functional and surgical outcomes of LPA in this context.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a systematic review and meta-analysis. MEDLINE and Embase were searched until May 2024. Biochemical and clinical outcomes were defined according to the PASO criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 3515 articles were initially identified, and eventually 20 studies (8 comparative and 12 single-arm) were included. The pooled biochemical success and clinical response rates (hypertension improvement) were estimated to be 100% (95% CI 99-100) and 91% (95% CI 48-99), respectively. The postoperative complication risk was very low (1%, 95% CI 0-4). The pooled recurrence risk was 0% (95% CI 0-1) over a mean follow-up of 25.9 months (range: 12-39 months). Eight comparative studies were combined in quantitative analyses. The biochemical success (OR 0.80, 95% CI 0.38-1.72), clinical cure (OR 1.07, 95% CI 0.77-1.50), recurrence (OR 1.57, 95% CI 0.25-9.77), and need for steroid supplementation (odds ratio [OR] 0.96, 95% CI 0.27-3.44) rates were similar between LPA and total adrenalectomy groups. Notwithstanding, LPA had a lower postoperative complication risk than total adrenalectomy (OR 0.51, 95% CI 0.31-0.82).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our systematic review underscores that LPA for treating APA has similar functional outcomes in terms of biochemical success and clinical response compared with total adrenalectomy, with fewer complications. However, given the observational nature of the currently available studies and the heterogeneity among them in the study population and surgical outcomes definitions, a clinical trial should be conducted to confirm these results.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ejendo\/lvaf180","type":"journal-article","created":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T11:26:12Z","timestamp":1756725972000},"page":"S36-S52","source":"Crossref","is-referenced-by-count":2,"title":["The role of adrenal-sparing surgery in the management of aldosterone-producing adenoma: a systematic review and meta-analysis"],"prefix":"10.1093","volume":"193","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0930-0344","authenticated-orcid":false,"given":"Alberto","family":"Artiles Medina","sequence":"first","affiliation":[{"name":"Urology Department, Hospital Universitario Ram\u00f3n y Cajal , Madrid 28034 ,","place":["Spain"]},{"name":"Instituto de Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria (IRYCIS), University of Alcal\u00e1 , Madrid 28034 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"G\u00f3mez Dos Santos","sequence":"additional","affiliation":[{"name":"Urology Department, Hospital Universitario Ram\u00f3n y Cajal , Madrid 28034 ,","place":["Spain"]},{"name":"Instituto de Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria (IRYCIS), University of Alcal\u00e1 , Madrid 28034 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9sar","family":"M\u00ednguez Ojeda","sequence":"additional","affiliation":[{"name":"Urology Department, Hospital Universitario Ram\u00f3n y Cajal , Madrid 28034 ,","place":["Spain"]},{"name":"Instituto de Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria (IRYCIS), University of Alcal\u00e1 , Madrid 28034 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Sanjuanbenito","sequence":"additional","affiliation":[{"name":"Instituto de Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria (IRYCIS), University of Alcal\u00e1 , Madrid 28034 ,","place":["Spain"]},{"name":"General Surgery Department, Hospital Universitario Ram\u00f3n y Cajal , Madrid 28034 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaqu\u00edn","family":"G\u00f3mez-Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Endocrine Surgery Unit. General Surgery Department, Hospital Universitario La Paz & Instituto de Investigac\u00f3n Hospital Universitario La Paz (IdiPAZ) , Madrid 28046 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Mercader","sequence":"additional","affiliation":[{"name":"General Surgery Department, Hospital Universitario Gregorio Mara\u00f1\u00f3n , Madrid 28007 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2399-4023","authenticated-orcid":false,"given":"Felicia A","family":"Hanzu","sequence":"additional","affiliation":[{"name":"Endocrinology and Nutrition Department, Hospital Clinic, University of Barcelona, IDIPAS , Barcelona 08036 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leire","family":"Zarain","sequence":"additional","affiliation":[{"name":"General Surgery Department, Hospital Universitario Gregorio Mara\u00f1\u00f3n , Madrid 28007 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d3scar","family":"Vidal","sequence":"additional","affiliation":[{"name":"General & Digestive Surgery Department, Hospital Clinic Barcelona, University of Barcelona, IDIBAPS , Barcelona 08036 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Muriel","sequence":"additional","affiliation":[{"name":"Clinical Biostatistics Unit, Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria (IRYCIS), CIBERESP, University of Alcal\u00e1 , Madrid 28034 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0519-0072","authenticated-orcid":false,"given":"Marta","family":"Araujo-Castro","sequence":"additional","affiliation":[{"name":"Instituto de Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria (IRYCIS), University of Alcal\u00e1 , Madrid 28034 ,","place":["Spain"]},{"name":"Endocrinology and Nutrition Department, Hospital Universitario Ram\u00f3n y Cajal , Madrid 28034 ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,9,8]]},"reference":[{"issue":"1","key":"2025092410363246500_lvaf180-B1","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1007\/S12020-024-03751-1","article-title":"Screening and diagnosis of primary aldosteronism. 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