{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T04:18:07Z","timestamp":1793852287395,"version":"4.6.1"},"reference-count":67,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T00:00:00Z","timestamp":1759190400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100010663","name":"European Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"name":"European Union\u2019s Horizon 2020 Framework Programme","award":["787270-Paget-Advance"],"award-info":[{"award-number":["787270-Paget-Advance"]}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["18163"],"award-info":[{"award-number":["18163"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000341","name":"Arthritis Research UK","doi-asserted-by":"publisher","award":["85281"],"award-info":[{"award-number":["85281"]}],"id":[{"id":"10.13039\/501100000341","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Paget\u2019s Association"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Paget's disease of bone is characterised by focal increases in osteoclastic bone resorption coupled to increased but disorganised bone formation. It is a relatively rare disease affecting up to 1% of individuals in the United Kingdom, but many cases are not diagnosed clinically. The most common presentation is with musculoskeletal pain which in some cases is due to increased bone turnover, but which can also be due to complications such as bone deformity, nerve compression syndromes and osteoarthritis. Predisposition to Paget's disease is regulated by pathogenic variants in or close to genes that regulate osteoclast differentiation and function. The most important of these is SQSTM1 which encodes p62\u2014a signalling protein in the NF\u03baB pathway. Environmental factors also influence susceptibility to PDB and disease severity, but the mechanisms are not well understood. Medical management is based on the use of bisphosphonates to supress the abnormal bone turnover and are indicated for the treatment of bone pain associated with the disease. Of the bisphosphonates currently available, intravenous zoledronic acid is the treatment of choice. The diagnosis can usually be made by typical features on X-ray and radionuclide bone scan. Genetic testing for pathogenic variants in the SQSTM1 gene in people with a family history of Paget's disease has been used to detect people with early asymptomatic disease, and in these individuals, prophylactic treatment with zoledronic acid favourably affects disease progression.<\/jats:p>","DOI":"10.1093\/ejendo\/lvaf202","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T11:54:21Z","timestamp":1759233261000},"page":"R43-R49","source":"Crossref","is-referenced-by-count":6,"title":["Latest developments in Paget's disease of bone"],"prefix":"10.1093","volume":"193","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2804-7586","authenticated-orcid":false,"given":"Stuart H","family":"Ralston","sequence":"first","affiliation":[{"name":"Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh , Edinburgh EH4 2XU ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,10,1]]},"reference":[{"key":"2025102906113549300_lvaf202-B1","first-page":"37","article-title":"On a form of chronic inflammation of bones (osteitis deformans)","volume":"ix","author":"Paget","year":"1876","journal-title":"Med Chir Trans"},{"issue":"5","key":"2025102906113549300_lvaf202-B2","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1007\/s00223-024-01297-y","article-title":"Influence of ethnicity and deprivation on occurrence of Paget's disease in Greater Manchester, UK","volume":"115","author":"Heald","year":"2024","journal-title":"Calcif Tissue Int"},{"key":"2025102906113549300_lvaf202-B3","doi-asserted-by":"publisher","first-page":"5668","DOI":"10.1093\/rheumatology\/keab232","article-title":"Incidence of Paget's disease of bone in the UK: evidence of a continuing decline","volume":"60","author":"Cook","year":"2021","journal-title":"Rheumatology (Oxford)"},{"issue":"7","key":"2025102906113549300_lvaf202-B4","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1056\/NEJMcp1204713","article-title":"Clinical practice. Paget's disease of bone","volume":"368","author":"Ralston","year":"2013","journal-title":"N Engl J Med"},{"issue":"4","key":"2025102906113549300_lvaf202-B5","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1093\/oxfordjournals.bmb.a072011","article-title":"The epidemiology of Paget's disease of bone","volume":"40","author":"Barker","year":"1984","journal-title":"Br Med Bull"},{"issue":"6347","key":"2025102906113549300_lvaf202-B6","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1136\/bmj.285.6347.1005","article-title":"European distribution of Paget's disease of bone","volume":"285","author":"Detheridge","year":"1982","journal-title":"Br Med J (Clin Res Ed)"},{"issue":"2","key":"2025102906113549300_lvaf202-B7","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/j.bone.2013.04.024","article-title":"Epidemiology of Paget's disease of bone: a systematic review and meta-analysis of secular changes","volume":"55","author":"Corral-Gudino","year":"2013","journal-title":"Bone"},{"issue":"3","key":"2025102906113549300_lvaf202-B8","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1359\/jbmr.2002.17.3.465","article-title":"Incidence and natural history of Paget's disease of bone in England and Wales","volume":"17","author":"van Staa","year":"2002","journal-title":"J Bone Miner Res"},{"key":"2025102906113549300_lvaf202-B9","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1007\/s00223-004-0281-z","article-title":"Paget's disease of bone in New Zealand: continued decline in disease severity","volume":"75","author":"Cundy","year":"2004","journal-title":"Calcif Tissue Int"},{"key":"2025102906113549300_lvaf202-B10","doi-asserted-by":"publisher","first-page":"1545","DOI":"10.1359\/jbmr.060704","article-title":"Epidemiology of Paget's disease in Europe: the prevalence is decreasing","volume":"21","author":"Po\u00f3r","year":"2006","journal-title":"J Bone Miner Res"},{"issue":"3","key":"2025102906113549300_lvaf202-B11","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1007\/s11914-021-00676-w","article-title":"Genetic determinants of Paget's disease of bone","volume":"19","author":"Makaram","year":"2021","journal-title":"Curr Osteoporos Rep"},{"issue":"4","key":"2025102906113549300_lvaf202-B12","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1002\/acn3.51751","article-title":"Multisystem proteinopathies (MSPs) and MSP-like disorders: clinical-pathological-molecular spectrum","volume":"10","author":"Chompoopong","year":"2023","journal-title":"Ann Clin Transl Neurol"},{"issue":"6","key":"2025102906113549300_lvaf202-B13","doi-asserted-by":"publisher","first-page":"e133113","DOI":"10.1172\/jci.insight.133113","article-title":"Osteoclast-derived IGF1 is required for pagetic lesion formation in vivo","volume":"5","author":"Miyagawa","year":"2020","journal-title":"JCI Insight"},{"issue":"1","key":"2025102906113549300_lvaf202-B14","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1172\/JCI115584","article-title":"Interleukin 6. A potential autocrine\/paracrine factor in Paget's disease of bone","volume":"89","author":"Roodman","year":"1992","journal-title":"J Clin Invest"},{"issue":"3","key":"2025102906113549300_lvaf202-B15","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1002\/art.10834","article-title":"Serum osteoprotegerin and its ligand in Paget's disease of bone: relationship to disease activity and effect of treatment with bisphosphonates","volume":"48","author":"Alvarez","year":"2003","journal-title":"Arthritis Rheum"},{"issue":"5","key":"2025102906113549300_lvaf202-B16","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1007\/s002239900254","article-title":"Cellular immunity aspects in elderly subjects with Paget's disease of bone","volume":"60","author":"Natale","year":"1997","journal-title":"Calcif. Tissue Int"},{"issue":"4","key":"2025102906113549300_lvaf202-B17","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1093\/qjmed\/95.4.233","article-title":"The influence of serum cytokines and growth factors on osteoclast formation in Paget's disease","volume":"95","author":"Neale","year":"2002","journal-title":"QJM"},{"key":"2025102906113549300_lvaf202-B18","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1007\/s00223-024-01279-0","article-title":"Causes of musculoskeletal pain in Paget's disease of bone","volume":"115","author":"Berg","year":"2024","journal-title":"Calcif Tissue Int"},{"key":"2025102906113549300_lvaf202-B19","doi-asserted-by":"publisher","first-page":"FRI-003","DOI":"10.1093\/jbmr\/zjae183","article-title":"Macrophage colony stimulating factor as an autocrine and paracrine mediator of Paget's disease of bone","volume":"39","author":"Azfer","year":"2024","journal-title":"J Bone Miner Res"},{"issue":"6","key":"2025102906113549300_lvaf202-B20","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1038\/ng.562","article-title":"Genome-wide association study identifies variants at CSF1, OPTN and TNFRSF11A as genetic risk factors for Paget's disease of bone","volume":"42","author":"Albagha","year":"2010","journal-title":"Nat Genet"},{"issue":"2","key":"2025102906113549300_lvaf202-B21","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1210\/jc.2008-1140","article-title":"Absence of somatic SQSTM1 mutations in Paget's disease of bone","volume":"94","author":"Matthews","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"2025102906113549300_lvaf202-B22","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1359\/jbmr.081105","article-title":"Somatic mutations in SQSTM1 detected in affected tissues from patients with sporadic Paget's disease of bone","volume":"24","author":"Merchant","year":"2009","journal-title":"J Bone Miner Res"},{"issue":"6168","key":"2025102906113549300_lvaf202-B23","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1136\/bmj.1.6168.931","article-title":"Billiard-player's fingers: an unusual case of Paget's disease of bone","volume":"1","author":"Solomon","year":"1979","journal-title":"Br Med J"},{"issue":"6172","key":"2025102906113549300_lvaf202-B24","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1136\/bmj.1.6172.1217-e","article-title":"Paget's disease in a treadle machine operator","volume":"1","author":"Gasper","year":"1979","journal-title":"Br Med J"},{"issue":"4","key":"2025102906113549300_lvaf202-B25","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/0049-0172(94)90037-X","article-title":"Epidemiological aspects of Paget's disease: family history and relationship to other medical conditions","volume":"23","author":"Siris","year":"1994","journal-title":"Semin Arthritis Rheum"},{"issue":"4","key":"2025102906113549300_lvaf202-B26","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1136\/jech.28.4.226","article-title":"Distribution of Paget's disease in England, Wales and Scotland and a possible relationship with vitamin D deficiency in childhood","volume":"28","author":"Barker","year":"1974","journal-title":"Br J Prev Soc Med"},{"issue":"4","key":"2025102906113549300_lvaf202-B27","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.jbspin.2011.07.005","article-title":"Epidemiogenetic study of French families with Paget's disease of bone","volume":"79","author":"Michou","year":"2012","journal-title":"Joint Bone Spine"},{"issue":"6","key":"2025102906113549300_lvaf202-B28","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1016\/j.jbspin.2016.11.010","article-title":"Environmental factors associated with familial or non-familial forms of Paget's disease of bone","volume":"84","author":"Audet","year":"2017","journal-title":"Joint Bone Spine"},{"issue":"2","key":"2025102906113549300_lvaf202-B29","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1007\/s00223-024-01241-0","article-title":"The decline of Paget's disease of bone and domestic coal use-A hypothesis","volume":"115","author":"Cundy","year":"2024","journal-title":"Calcif Tissue Int"},{"issue":"5","key":"2025102906113549300_lvaf202-B30","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1007\/s002239900552","article-title":"Is there any association between the presence of bone disease and cumulative exposure to lead?","volume":"63","author":"Adachi","year":"1998","journal-title":"Calcif Tissue Int"},{"issue":"5","key":"2025102906113549300_lvaf202-B31","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1016\/0160-4120(94)90008-6","article-title":"Occupational and environmental exposure to lead and Paget's disease of bone","volume":"20","author":"Spencer","year":"1994","journal-title":"Environ Int"},{"issue":"6222","key":"2025102906113549300_lvaf202-B32","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1136\/bmj.280.6222.1105","article-title":"Paget's disease of bone: the lancashire focus","volume":"280","author":"Barker","year":"1980","journal-title":"Br Med J"},{"issue":"9","key":"2025102906113549300_lvaf202-B33","doi-asserted-by":"publisher","first-page":"5081","DOI":"10.1093\/rheumatology\/keaf280","article-title":"Continuous decline in Paget's disease of bone: a one health perspective on 2,342 new diagnoses and their association with rural livestock","volume":"64","author":"Rebollo-Najera","year":"2025","journal-title":"Rheumatology (Oxford)"},{"issue":"8","key":"2025102906113549300_lvaf202-B34","doi-asserted-by":"publisher","first-page":"1356","DOI":"10.1359\/JBMR.050322","article-title":"Characteristics and familial aggregation of Paget's disease of bone in Italy","volume":"20","author":"Merlotti","year":"2005","journal-title":"J Bone Miner Res."},{"issue":"2","key":"2025102906113549300_lvaf202-B35","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1007\/s00223-017-0265-4","article-title":"Antibody response to paramyxoviruses in Paget's disease of bone","volume":"101","author":"Visconti","year":"2017","journal-title":"Calcif Tissue Int"},{"issue":"5","key":"2025102906113549300_lvaf202-B36","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1007\/s00223-019-00522-3","article-title":"Paget's disease of bone","volume":"104","author":"Gennari","year":"2019","journal-title":"Calcif Tissue Int"},{"issue":"4","key":"2025102906113549300_lvaf202-B37","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1359\/jbmr.070103","article-title":"Multicenter blinded analysis of RT-PCR detection methods for paramyxoviruses in relation to Paget's disease of bone","volume":"22","author":"Ralston","year":"2007","journal-title":"J Bone Miner Res"},{"issue":"S2","key":"2025102906113549300_lvaf202-B38","doi-asserted-by":"publisher","first-page":"P38","DOI":"10.1359\/jbmr.06s207","article-title":"Sequestosome 1: mutation frequencies, haplotypes, and phenotypes in familial Paget's disease of bone","volume":"21","author":"Morissette","year":"2006","journal-title":"J Bone Miner Res"},{"issue":"3","key":"2025102906113549300_lvaf202-B39","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1136\/jech.37.3.226","article-title":"A family study of Paget's disease of bone","volume":"37","author":"Sofaer","year":"1983","journal-title":"J Epidemiol Commun Health"},{"issue":"5","key":"2025102906113549300_lvaf202-B40","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1002\/jbmr.5650060511","article-title":"Familial aggregation of Paget's disease of bone","volume":"6","author":"Siris","year":"1991","journal-title":"J Bone Miner Res"},{"issue":"5","key":"2025102906113549300_lvaf202-B41","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1007\/s00223-019-00520-5","article-title":"Rare inherited forms of Paget's disease and related syndromes","volume":"104","author":"Ralston","year":"2019","journal-title":"Calcif Tissue Int"},{"issue":"6","key":"2025102906113549300_lvaf202-B42","doi-asserted-by":"publisher","first-page":"1582","DOI":"10.1086\/340731","article-title":"Recurrent mutation of the gene encoding sequestosome 1 (SQSTM1\/p62) in paget disease of bone","volume":"70","author":"Laurin","year":"2002","journal-title":"Am J Hum Genet"},{"issue":"22","key":"2025102906113549300_lvaf202-B43","doi-asserted-by":"publisher","first-page":"2735","DOI":"10.1093\/hmg\/11.22.2735","article-title":"Domain-specific mutations in sequestosome 1 (SQSTM1) cause familial and sporadic Paget's disease","volume":"11","author":"Hocking","year":"2002","journal-title":"Hum Mol Genet"},{"issue":"1","key":"2025102906113549300_lvaf202-B44","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1359\/jbmr.090709","article-title":"Randomized trial of intensive bisphosphonate treatment versus symptomatic management in Paget's disease of bone","volume":"25","author":"Langston","year":"2010","journal-title":"J Bone Miner Res"},{"issue":"8","key":"2025102906113549300_lvaf202-B45","doi-asserted-by":"publisher","first-page":"1385","DOI":"10.1002\/jbmr.4090","article-title":"A new gene for susceptibility to Paget's disease of bone and for multisystem proteinopathy","volume":"35","author":"Ralston","year":"2020","journal-title":"J Bone Miner Res"},{"key":"2025102906113549300_lvaf202-B46","doi-asserted-by":"publisher","first-page":"903612","DOI":"10.3389\/fcell.2022.903612","article-title":"Epigenetic DNA methylation signatures associated with the severity of Paget's disease of bone","volume":"10","author":"Diboun","year":"2022","journal-title":"Front Cell Dev Biol"},{"key":"2025102906113549300_lvaf202-B47","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.65715","article-title":"Epigenetic analysis of Paget's disease of bone identifies differentially methylated loci that predict disease status","volume":"10","author":"Diboun","year":"2021","journal-title":"Elife"},{"issue":"5","key":"2025102906113549300_lvaf202-B48","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1007\/s00223-014-9904-1","article-title":"Clinical presentation of Paget's disease: evaluation of a contemporary cohort and systematic review","volume":"95","author":"Tan","year":"2014","journal-title":"Calcif Tissue Int"},{"issue":"1-2","key":"2025102906113549300_lvaf202-B49","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/0378-5955(94)00196-W","article-title":"Hearing loss in Paget's disease of bone: the relationship between pure-tone thresholds and mineral density of the cochlear capsule","volume":"83","author":"Monsell","year":"1995","journal-title":"Hear Res"},{"key":"2025102906113549300_lvaf202-B50","first-page":"27","article-title":"Hearing loss in Paget's disease of bone: evidence of auditory nerve integrity","volume":"16","author":"Monsell","year":"1995","journal-title":"Am J Otol"},{"issue":"6","key":"2025102906113549300_lvaf202-B51","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1359\/jbmr.080215","article-title":"Morbidity and mortality associated with Paget's disease of bone: a population-based study","volume":"23","author":"Wermers","year":"2008","journal-title":"J Bone Miner Res"},{"issue":"4","key":"2025102906113549300_lvaf202-B52","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1111\/j.1365-2354.2005.00597.x","article-title":"Scapulo-humeral Paget's sarcoma: Scottish bone tumour registry experience","volume":"14","author":"Sharma","year":"2005","journal-title":"Eur J Cancer Care (Engl)"},{"issue":"12","key":"2025102906113549300_lvaf202-B53","doi-asserted-by":"publisher","first-page":"2327","DOI":"10.1002\/jbmr.3873","article-title":"Clinical guidelines on Paget's disease of bone","volume":"34","author":"Ralston","year":"2019","journal-title":"J Bone Miner Res"},{"key":"2025102906113549300_lvaf202-B54","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.bone.2016.01.007","article-title":"Development of a molecular test of Paget's disease of bone","volume":"84","author":"Guay-B\u00e9langer","year":"2016","journal-title":"Bone"},{"issue":"7","key":"2025102906113549300_lvaf202-B55","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1038\/ng.845","article-title":"Genome-wide association identifies three new susceptibility loci for Paget's disease of bone","volume":"43","author":"Albagha","year":"2011","journal-title":"Nat Genet"},{"issue":"11","key":"2025102906113549300_lvaf202-B56","doi-asserted-by":"publisher","first-page":"2238","DOI":"10.1002\/jbmr.1975","article-title":"Common susceptibility alleles and SQSTM1 mutations predict disease extent and severity in a multinational study of patients with Paget's disease","volume":"28","author":"Albagha","year":"2013","journal-title":"J Bone Miner Res"},{"issue":"7","key":"2025102906113549300_lvaf202-B57","doi-asserted-by":"publisher","first-page":"1246","DOI":"10.1002\/jbmr.4007","article-title":"Characteristics of early Paget's disease in SQSTM1 mutation carriers: baseline analysis of the ZiPP study cohort","volume":"35","author":"Cronin","year":"2020","journal-title":"J Bone Miner Res"},{"issue":"12","key":"2025102906113549300_lvaf202-B58","doi-asserted-by":"publisher","first-page":"CD004956","DOI":"10.1002\/14651858.CD004956.pub3","article-title":"Bisphosphonates for Paget's disease of bone in adults","volume":"12","author":"Corral-Gudino","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"2025102906113549300_lvaf202-B59","doi-asserted-by":"publisher","first-page":"115465","DOI":"10.1016\/j.bone.2020.115465","article-title":"Bisphosphonates in the management of Paget's disease","volume":"138","author":"Ralston","year":"2020","journal-title":"Bone"},{"issue":"9","key":"2025102906113549300_lvaf202-B60","doi-asserted-by":"publisher","first-page":"2261","DOI":"10.1002\/jbmr.438","article-title":"A single infusion of zoledronic acid produces sustained remissions in paget disease: data to 6.5 years","volume":"26","author":"Reid","year":"2011","journal-title":"J Bone Miner Res"},{"issue":"9","key":"2025102906113549300_lvaf202-B61","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1056\/NEJMoa044241","article-title":"Comparison of a single infusion of zoledronic acid with risedronate for Paget's disease","volume":"353","author":"Reid","year":"2005","journal-title":"N Engl J Med"},{"issue":"6","key":"2025102906113549300_lvaf202-B62","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1002\/jbmr.3066","article-title":"Long-term randomized trial of intensive versus symptomatic management in Paget's disease of bone: the PRISM-EZ study","volume":"32","author":"Tan","year":"2017","journal-title":"J Bone Miner Res"},{"issue":"5","key":"2025102906113549300_lvaf202-B63","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1002\/jbmr.4802","article-title":"Effect of a three-day course of dexamethasone on acute phase response following treatment with zoledronate: a randomized controlled trial","volume":"38","author":"Murdoch","year":"2023","journal-title":"J Bone Miner Res"},{"issue":"4","key":"2025102906113549300_lvaf202-B64","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1136\/ard-2023-224990","article-title":"Randomised trial of genetic testing and targeted intervention to prevent the development and progression of Paget's disease of bone","volume":"83","author":"Phillips","year":"2024","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"2025102906113549300_lvaf202-B65","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1111\/j.1445-5994.1979.tb04110.x","article-title":"Treatment of Paget's disease with the calcitonins","volume":"9","author":"Martin","year":"1979","journal-title":"Aust N Z J Med"},{"key":"2025102906113549300_lvaf202-B66","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1007\/s00223-016-0150-6","article-title":"Treatment of Paget's disease of bone with denosumab: case report and literature review","volume":"99","author":"Reid","year":"2016","journal-title":"Calcif Tissue Int"},{"issue":"7","key":"2025102906113549300_lvaf202-B67","doi-asserted-by":"publisher","first-page":"1400","DOI":"10.1016\/j.arth.2023.01.004","article-title":"Outcomes following total hip and knee arthroplasty in patients who have Paget's disease of bone: a systematic review","volume":"38","author":"Arif","year":"2023","journal-title":"J Arthroplasty"}],"container-title":["European Journal of Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ejendo\/advance-article-pdf\/doi\/10.1093\/ejendo\/lvaf202\/64472832\/lvaf202.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ejendo\/article-pdf\/193\/4\/R43\/64472832\/lvaf202.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ejendo\/article-pdf\/193\/4\/R43\/64472832\/lvaf202.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T10:25:22Z","timestamp":1761733522000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/193\/4\/R43\/8271036"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,30]]},"references-count":67,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,9,30]]}},"URL":"https:\/\/doi.org\/10.1093\/ejendo\/lvaf202","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,10]]},"published":{"date-parts":[[2025,9,30]]}}}